Osmotic dosage system for liquid drug delivery

• US 5,413,572 A
• Filed: 02/18/1994
• Issued: 05/09/1995
• Est. Priority Date: 04/02/1990
• Status: Expired due to Term

• Current Assignee: ALZA Corporation (Johnson & Johnson)
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: Theeuwes, Felix, Wong, Patrick S. L., Barclay, Brian L., Dealey, Michael H.
• Primary Examiner(s): Rosenbaum, C. Fred
• Assistant Examiner(s): STRIGHT, RONALD K
• Application Number:
  US08/203,135
• Time in Patent Office: 445 Days
• Field of Search: 604/890.1-892.1, 424/422, 424/427, 424/438, 424/453, 424/462, 424/463, 424/468, 424/471, 424/472, 424/474, 424/482
• US Class Current: 604/892.1
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas

Abstract

An osmotic system is disclosed for delivering a beneficial agent formulation to an environment of use. The osmotic system comprises (a) an outside semipermeable wall, (b) a middle osmotically active layer, (c) a capsule comprising a beneficial agent, and (d) a passageway for dispensing the beneficial agent from the osmotic system.

Claims

1. An osmotic system for delivering a therapeutic drug formulation to an environment of use, wherein the osmotic system comprises:

(a) a capsule comprising an internal lumen;

said capsule formed of gelatin having a viscosity of 15 to 20 millipoises;

(b) a dosage amount of a therapeutic drug liquid formulation in the capsule lumen;

(c) a hydroactivated composition on the outside wall of the capsule;

d) a semipermeable composition surrounding the hydroactivated composition; and

,

e) a passageway that communicates the exterior with the interior of the osmotic system, which passageway is formed by a process selected from the group consisting of drilling, eroding, extracting, dissolving, bursting, and leaching a passageway in the osmotic system.

2. An osmotic system for delivering a therapeutic drug formulation to an environment of use, wherein the osmotic system comprises:

a) a capsule comprising a gelatin wall having a bloom value of 160 to 250 and an internal lumen;

b) a dosage amount of a therapeutic drug liquid formulation in the capsule lumen;

c) a hydroactivated composition on the outside wall of the capsule;

d) a semipermeable composition surrounding the hydroactivated composition;

e) a passageway in the osmotic system that connects the exterior with the interior of the osmotic system, and wherein;

f) the osmotic system is shaped and adapted for admittance into a buccal, implant, anal, cervical, vaginal, subcutaneous, oral and nose environment of use.