Method of improving fat saturation during MRI

• US 5,414,358 A
• Filed: 08/05/1993
• Issued: 05/09/1995
• Est. Priority Date: 08/11/1992
• Status: Expired due to Term

• Current Assignee: Alliance Pharmaceutical Corporation
• Original Assignee: Alliance Pharmaceutical Corporation
• Inventors: Walters, Mark, Eilenberg, Steven S., DeFranco, Jack, Kirkland, W. Dean
• Primary Examiner(s): ARANA, LOUIS M
• Application Number:
  US08/102,580
• Time in Patent Office: 642 Days
• Field of Search: 324/300, 324/307, 324/309, 324/311, 324/314, 324/322, 324/318, 128/653.4, 128/653.5, 128/654
• US Class Current: 324/309
• CPC Class Codes: G01R 33/28 Details of apparatus provided for in groups G01R33/44 - G01R33/64
• CPC Class Codes: G01R 33/3678 involving quadrature drive or detection, e.g. a circularly polarized RF magnetic field

Abstract

A method for improving fat saturation during magnetic resonance imaging (MRI) by placing a fat saturation enhancing material such as a fluorocarbon, preferably perfluorooctylbromide, perfluorodecylbromide, FC-77, or FC-43, on or around a part of the body of a patient to be scanned with MRI, thereby eliminating the skin-air interface and reducing anatomical imaging problems, wherein the placement of the fat saturation enhancing material may be accomplished by enclosing the fat saturation enhancing material in a container which may also contain the MRI coil.

Claims

1. A method of improving fat saturation during magnetic resonance imaging, comprising:

placing nonaqueous solid or liquid fat saturation enhancing material in a container that is placed against a portion of tissue to be imaged with a magnetic resonance imaging system;

imaging said tissue with a magnetic resonance imaging system.

2. The method of claim 1, wherein said fat saturation enhancing material includes, at least in part, a material enclosed in a container.

3. The method of claim 2, wherein said container is flexible.

4. The method of claim 3, wherein said container is formed from thin sheets.

5. The method of claim 4, wherein said sheets are made from a material selected from the group consisting of ethylvinylacetate, polyurethane, nylon, polyethylene, and polyester.

6. The method of claim 2, wherein said container is a bag.

7. The method of claim 6, wherein said bag has a hollow portion and is mounted within an outer shell.

8. The method of claim 2, wherein said container is selectively fillable.

9. The method of claim 2, wherein said container also contains a space-filling material in the fat saturation enhancing material.

10. The method of claim 9, wherein said space filling material is selected from the group consisting of:

silica, diatomaceous earth, polyurethane foam, rubber foams, polyester, absorbent cloth, and absorbent paper.

11. The method of claim 1, wherein the fat saturation enhancing material comprises a fluorocarbon.

12. The method of claim 2, wherein the fat saturation enhancing material is a fluorocarbon material selected from the group consisting of perfluorooctylbromide, perfluorodecylbromide, FC-77 and FC-43.

13. The method of claim 1, wherein the fat saturation enhancing material comprises a non-protonated or minimally protonated material.

14. The method of claim 1, wherein the fat saturation enhancing material comprises a compound in which the protons of the said material do not resonate at the same frequency as protons imaged by said magnetic resonance imaging system.

15. The method of claim 2, wherein said container surrounds a flexible magnetic resonance imaging coil.

16. The method of claim 2, additionally comprising the step of stacking a plurality of containers around a part of the body of a patient to be imaged.

17. The method of claim 16, wherein said plurality of containers are joined to each other in order to secure said containers at or around said part of the body.

18. The method of claim 2, wherein said placing step comprises placing said container so that said container concentrically surrounds said part of the body.

19. A device for enhancing the fat saturation ability of a magnetic resonance imaging system, comprising:

a container adapted to be placed in contact with a body part to be imaged with MRI, to minimize the body-air interface; and

a fat saturation enhancing material in said container.

20. The device of claim 19, wherein said container is flexible.

21. The device of claim 20, wherein said container is formed from thin sheets.

22. The device of claim 21, wherein said sheets are made from a material selected from the group consisting of ethylvinylacetate, polyurethane, nylon, polyethylene, and polyester.

23. The device of claim 19, wherein said container is a bag.

24. The device of claim 23, wherein said container further encloses a MR imaging coil.

25. The device of claim 24, wherein said imaging coil and said container are flexible.

26. The device of claim 23, wherein said bag has a hollow portion and is mounted within an outer shell that is more rigid than the bag.

27. The device of claim 19, wherein said container is selectively fillable.

28. The device of claim 19, wherein said container has fastening means for securing one container to another when such containers are placed at or around a part of the body to be imaged.

29. The device of claim 19, wherein said container also contains a space-filling solid material.

30. The device of claim 29, wherein said space-filling material is selected from the group consisting of:

silica, diatomaceous earth, polyurethane foam, rubber foams, polyester, absorbent cloth, and absorbent paper.

31. The device of claim 19, wherein the fat saturation enhancing material comprises a fluorocarbon.

32. The device of claim 31, wherein the fluorocarbon material is selected from the group consisting of perfluorooctylbromide, perfluorodecylbromide, FC-77 and FC-43.

33. The device of claim 19, wherein the fat saturation enhancing material comprises a non-protonated or minimally protonated material.

34. The device of claim 19, wherein the fat saturation enhancing material comprises a compound in which the protons of said material do not resonate at the same frequency as protons imaged by said MRI device.