Multi-dose dry powder inhalation device

• US 5,415,162 A
• Filed: 01/18/1994
• Issued: 05/16/1995
• Est. Priority Date: 01/18/1994
• Status: Expired due to Term

• Current Assignee: Glaxo, Inc. (GSK plc)
• Original Assignee: Glaxo, Inc. (GSK plc)
• Inventors: Taylor, Malcolm E., Boundy, Maryanne G., Leith, David H., Casper, Robert A., Leith, Frank A.
• Primary Examiner(s): Burr, Edgar S.
• Assistant Examiner(s): SRIVASTAVA, VIRENDRA KUMAR
• Application Number:
  US08/183,283
• Time in Patent Office: 483 Days
• Field of Search: 128/203.12, 128/203.15, 128/203.18, 128/203.19, 128/203.21, 128/200.14, 128/205.29, 222/81, 222/82, 222/630, 609/58
• US Class Current: 128/203.12
• CPC Class Codes: A61M 15/0035 Piercing means
• CPC Class Codes: A61M 15/0045 using multiple prepacked dosages on a same carrier, e.g. blisters
• CPC Class Codes: A61M 15/005 the dosages being arranged on a cylindrical surface
• CPC Class Codes: A61M 2202/064 Powder

Abstract

A breath-actuated dry powder medicament inhalator device having a housing and a conduit mounted within the housing defining an air passageway therethrough having an aperture in the sidewall thereof. A blister-type strip of sealed containers arranged in a matrix of rows and columns wherein the columns extend generally diagonally to the longitudinal axis of the strip is secured in a two-piece cage adapted for being rotatably mounted around the conduit of the inhalator device. Advancement means are provided for rotatably moving the two-piece cage and blister strip contained thereby in a generally helical pathway relative to the conduit so as to successively advance each of the sealed containers of the blister strip into registration with the conduit aperture. Piercing means are associated with the housing for successively piercing each of the sealed containers of the blister strip when advanced into registration with the conduit aperture by the advancement means in order to introduce the dry powder compound contained therein into the air passageway of the conduit.

Claims

1. A portable device for the inhalation of a predetermined amount of dry powder compound from a blister-type strip of sealed containers, comprising:

(a) a housing;

(b) a conduit mounted within said housing defining an air passageway therethrough and having an air inlet end and an air exit end and an aperture extending through a side wall of said conduit therebetween, said air exit end being adapted for insertion into the mouth of a user;

(c) a blister-type strip of sealed containers wherein said sealed containers are arranged in a matrix of rows and columns and said columns extend generally diagonally to the longitudinal axis of said strip;

(d) cage means for rotatably mounting said blister-type strip of sealed containers of dry powder compound in a cylindrical configuration around said conduit wherein said rows of said blister-type strip extend generally parallel to the longitudinal axis of said conduit;

(e) advancement means associated with said housing for rotatably moving said cage means in a generally helical pathway relative to said conduit so as to successively advance each of said sealed containers of said blister-type strip into registration with the aperture of said conduit; and

(f) piercing means associated with said housing for piercing each of said sealed containers of said blister strip when advanced into registration with the aperture of said conduit so as to introduce said dry powder compound therein into the air passageway of said conduit;

whereby said blister-type strip will be rotatably and axially moved relative to said conduit as said sealed containers thereof are advanced along said helical pathway and successively pierced for administration of a predetermined amount of said dry powder compound from said inhalation device.

2. A portable device according to claim 1 wherein said housing defines a generally cylindrical shape having a longitudinal axis extending generally coaxially with the longitudinal axis of said conduit.

3. A portable device according to claim 2 wherein the inside surface of said, housing is radially spaced apart from the outside surface of said conduit so as to define a space therebetween for receiving said cage means.

4. A portable device according to claim 2 wherein said housing defines an opening around the circumference of said air inlet end of said conduit so as to receive said cage means therethrough.

5. A portable device according to claim 1 wherein said air passageway defined within said conduit comprises a venturi in the medial portion of the length thereof, and said aperture extending through said conduit has one end on the outside surface of said conduit and the other end opens into said venturi of said conduit.

6. A portable device according to claim 5 wherein said aperture of said conduit includes an enlarged swirl chamber between said inlet end and said outlet end thereof.

7. A portable device according to claim 1 wherein said blister-type strip comprises 15 rows of sealed containers extending generally normally to the longitudinal axis of said strip and 4 columns of sealed containers each extending generally parallel to each other and diagonally to the longitudinal axis of said strip.

8. A portable device according to claim 1 wherein said blister-type strip comprises 15 rows of sealed containers extending generally normally to the longitudinal axis of said strip and 8 columns of sealed containers each extending generally parallel to each other and diagonally to the longitudinal axis of said strip.

9. A portable device according to claim 1 wherein said cage means comprises:

a first flexible strip defining a plurality of cavities therein so that when said blister-type strip is placed in overlying relationship thereto said sealed containers of said blister-type strip will each nest in a corresponding one of said plurality of cavities of said first strip;

a second flexible strip defining a plurality of apertures therein so that when said second strip is placed in overlying relationship to said blister-type strip and said first strip, said apertures of said second strip will each be in vertical registration with a corresponding one of said sealed containers of said blister-type strip;

said first and second strips being adapted to be secured together as an assembly with said blister-type strip positioned therebetween and said assembly then formed into a cylindrical configuration for positioning around said conduit.

10. A portable device according to claim 9 wherein said cage means is disposable.

11. A portable device according to claim 1 wherein said advancement means comprises:

a plurality of protuberances arranged in a helix on the outside surface of said conduit defining said air passageway and serving to guide the movement of said cage around said conduit along the helical pathway defined by said protuberances; and

ratchet means reciprocatingly mounted to said housing and adapted to cooperatively engage said cage means and to rotate said cage means about said conduit a sufficient distance to advance the next successive row of sealed containers of said blister-type strip such that one of said sealed containers thereof will be in registration with the aperture of said conduit.

12. A portable device according to claim 1 wherein said piercing means comprises a needle element adapted for vertical movement from a retracted position to an extended position wherein said needle element pierces said sealed container in registration with the aperture of said conduit.

13. A portable device according to claim 12 wherein said piercing means comprises an air vent therein to allow for air entry into said air passageway of said conduit from outside said housing subsequent to piercing of said sealed container by said needle element.

14. In a portable device for the inhalation of a predetermined amount of dry powder compound and characterized by a housing;

an air passageway provided within said housing having an air inlet end, an air exit end adapted for insertion into the mouth of a user, and an aperture through a side wall at a predetermined location along the length thereof; and

piercing means associated with said housing for piercing a sealed container of said dry powder compound when positioned in registration with the aperture of said air passageway so as to introduce said dry powder compound into the air passageway, the improvement comprising;

a blister-type strip of sealed containers of dry powder compound arranged in a matrix of rows and columns wherein said columns extend generally parallel to each other and generally diagonally to the longitudinal axis of said strip;

cage means for rotatably mounting said blister-type strip of sealed containers in a cylindrical configuration within said housing and around said air passageway wherein said rows of said blister-type strip extend generally parallel to the longitudinal axis of said air passageway; and

advancement means associated with said housing for rotatably moving said cage means in a generally helical pathway relative to said air passageway so as to successively advance each of said sealed containers of said blister-type strip into registration with the aperture of said air passageway;

whereby said blister-type strip will be rotatably and axially moved relative to said air passageway as said sealed containers thereof are advanced along said helical pathway and successively pierced for administration of a predetermined amount of said dry powder compound from said inhalation device.

15. A portable device according to claim 14 wherein said air passageway is defined by a conduit and the inside surface of said housing is radially spaced apart from the outside surface of said conduit so as to define a space therebetween for receiving said cage means.

16. A portable device according to claim 15 wherein said housing defines an opening around the circumference of said air inlet end of said conduit so as to receive said cage means therethrough.

17. A portable device according to claim 14 wherein said blister-type strip comprises 15 rows of sealed containers extending generally normally to the longitudinal axis of said strip and 4 columns of sealed containers each extending generally parallel to each other and diagonally to the longitudinal axis of said strip.

18. A portable device according to claim 14 wherein said blister-type strip comprises 15 rows of sealed containers extending generally normally to the longitudinal axis of said strip and 8 columns of sealed containers each extending generally parallel to each other and diagonally to the longitudinal axis of said strip.

19. A portable device according to claim 15 wherein said cage means comprises:

a first flexible strip defining a plurality of cavities therein so that when said blister-type strip is placed in overlying relationship thereto said sealed containers of said blister-type strip will each nest in a corresponding one of said plurality of cavities of said first strip;

a second flexible strip defining a plurality of apertures therein so that when said second strip is placed in overlying relationship thereto said blister-type strip and said first strip, said apertures of said second strip will each be in vertical registration with a corresponding one of said sealed containers of said blister-type strip;

said first and second strips being adapted to be secured together as an assembly with said blister-type strip positioned therebetween and said assembly then formed into a cylindrical configuration for positioning around said conduit.

20. A portable device according to claim 19 wherein said cage means is disposable.

21. A portable device according to claim 15 wherein said advancement means comprises:

a plurality of protuberances arranged in a helix on the outside surface of said conduit and serve to guide the movement of said cage around said conduit along the helical pathway defined by said protuberances;

ratchet means reciprocatingly mounted to said housing and adapted to cooperatively engage said cage means and to rotate said cage means about said conduit a sufficient distance to advance the next successive row of sealed containers of said blister-type strip such that one of said sealed containers thereof will be in registration with the aperture of said air passageway.

22. A portable device according to claim 21 wherein said advancement means successively helically advances said cage means and blister-type strip contained thereby from an innermost first position within the housing of said portable inhalation device to a second outermost position wherein at least a portion of said cage means and blister-type strip contained thereby are outside of the housing.

23. A portable device for the inhalation of a predetermined amount of dry powder compound from a blister-type strip of sealed containers, comprising:

(a) a housing;

(b) a conduit mounted within said housing defining an air passageway therethrough and having an air inlet end and an air exit end and an aperture extending through a side wall of said conduit therebetween, said air exit end being adapted for insertion into the mouth of a user;

(c) a blister-type strip of sealed containers wherein said sealed containers are arranged in a matrix of rows and columns;

(d) cage means for rotatably mounting said blister-type strip of sealed containers of dry powder compound in a cylindrical configuration around said conduit;

(e) advancement means associated with said housing for rotatably moving said cage means relative to said conduit so as to successively advance each of said sealed containers of said blister-type strip into registration with the aperture of said conduit; and

(f) piercing means associated with said housing for piercing each of said sealed containers of said blister strip when advanced into registration with the aperture of said conduit so as to introduce said dry powder compound therein into the air passageway of said conduit;

whereby said blister-type strip will be moved relative to said conduit as said sealed containers thereof are advanced and successively pierced for periodic administration of a predetermined amount of said dry powder compound from said inhalation device.

24. A portable device according to claim 23 wherein said housing defines a generally cylindrical shape having a longitudinal axis extending generally coaxially with the longitudinal axis of said conduit.

25. A portable device according to claim 24 wherein the inside surface of said housing is radially spaced apart from the outside surface of said conduit so as to define a space therebetween for receiving said cage means.

26. A portable device according to claim 24 wherein said housing defines an opening around the circumference of said air inlet end of said conduit so as to receive said cage means therethrough.

27. A portable device according to claim 23 wherein said air passageway defined within said conduit comprises a venturi in the medial portion of the length thereof, and said aperture extending through said conduit has one end on the outside surface of said conduit and the other end opens into said venturi of said conduit.

28. A portable device according to claim 27 wherein said aperture of said conduit includes an enlarged swirl chamber between said inlet end and said outlet end thereof.

29. A portable device according to claim 23 wherein said cage means comprises:

a first flexible strip defining a plurality of cavities therein so that when said blister-type strip is placed in overlying relationship thereto said sealed containers of said blister-type strip will each nest in a corresponding one of said plurality of cavities of said first strip;

a second flexible strip defining a plurality of apertures therein so that when said second strip is placed in overlying relationship to said blister-type strip and said first strip, said apertures of said second strip will each be in vertical registration with a corresponding one of said sealed containers of said blister-type strip;

said first and second strips being adapted to be secured together as an assembly with said blister-type strip positioned therebetween and said assembly then formed into a cylindrical configuration for positioning around said conduit.

30. A portable device according to claim 29 wherein said cage means is disposable.

31. A portable device according to claim 23 wherein said advancement means comprises:

a plurality of protuberances on the outside surface of said conduit defining said air passageway and serving to guide the movement of said cage around said conduit along a pathway defined by said protuberances; and

ratchet means reciprocatingly mounted to said housing and adapted to cooperatively engage said cage means and to rotate said cage means about said conduit a sufficient distance to advance said blister-type strip such that successive sealed containers thereof will be in registration with the aperture of said conduit.

32. A portable device according to claim 23 wherein said piercing means comprises a needle element adapted for vertical movement from a retracted position to an extended position wherein said needle element pierces said sealed container in registration with the aperture of said conduit.

33. A portable device according to claim 32 wherein said piercing means comprises an air vent therein to allow for air entry into said air passageway of said conduit from outside said housing subsequent to piercing of said sealed container by said needle element.