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Biocompatability of solid surfaces

  • US 5,415,938 A
  • Filed: 02/09/1994
  • Issued: 05/16/1995
  • Est. Priority Date: 01/19/1993
  • Status: Expired due to Term
First Claim
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1. A spacer for attaching a biomolecule to a solid surface comprising, in combination:

  • (a) an aminated substrate including acrylamide graft polymerized onto the substrate anal spaced pendant amine groups extending from the graft polyacrylamide and covalently attached to the graft polyacrylamide;

    (b) a polyalkylimine covalently attached to the pendant amine groups of the aminated substrate; and

    (c) a crosslinking agent which is at least difunctional in aldehyde groups providing the covalent attachment of the polyalkylimine to the pendant amine groups of the aminated substrate.

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