Coupling reagent and method

• US 5,416,193 A
• Filed: 04/30/1993
• Issued: 05/16/1995
• Est. Priority Date: 04/30/1993
• Status: Expired due to Fees

• Current Assignee: Pfizer Inc.
• Original Assignee: Pfizer Inc.
• Inventors: Desai, Manoj C.
• Primary Examiner(s): Warden, Jill
• Assistant Examiner(s): Lukton, David
• Application Number:
  US08/056,261
• Time in Patent Office: 746 Days
• Field of Search: 530/333, 530/334, 530/338, 530/339, 530/344
• US Class Current: 530/334
• CPC Class Codes: C07C 231/02 from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
• CPC Class Codes: C07C 267/00 Carbodiimides
• CPC Class Codes: C07C 269/06 by reactions not involving the formation of carbamate groups
• CPC Class Codes: C07D 213/74 Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
• CPC Class Codes: C07D 261/14 Nitrogen atoms
• CPC Class Codes: C07D 295/13 to an acyclic saturated chain
• CPC Class Codes: C07D 307/14 Radicals substituted by nitrogen atoms not forming part of a nitro radical
• CPC Class Codes: C07D 401/06 linked by a carbon chain containing only aliphatic carbon atoms
• CPC Class Codes: C07D 403/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 409/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 409/14 containing three or more hetero rings
• CPC Class Codes: C07D 413/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 471/04 Ortho-condensed systems
• CPC Class Codes: C07D 471/10 Spiro-condensed systems
• CPC Class Codes: C07K 1/10 using coupling agents C07K1/006 takes precedence

Abstract

A solid phase coupling reagent for amide formation, comprising insoluble polymer bearing pendant side chains, said side chains each comprising a terminal portion having the formula ##STR1## wherein Y^- is a counteranion and n is independently an integer from 2 to 6; and a method of making amides employing the coupling reagent.

Claims

1. A solid phase coupling reagent, comprising an insoluble polymer bearing pendant side chains, said side chains each comprising a terminal portion having the formula ##STR63## wherein Y^- is a counteranion and n is independently an integer from 2 to 6.

2. A solid phase coupling reagent as defined in claim 1, wherein n is 3.

3. A solid phase coupling reagent as defined in claim 1, wherein said polymer is polystyrene crosslinked with divinyl benzene.