Magnetic resonance arteriography with dynamic intravenous contrast agents

• US 5,417,213 A
• Filed: 06/07/1993
• Issued: 05/23/1995
• Est. Priority Date: 06/07/1993
• Status: Expired due to Term

• Current Assignee: Martin R. Prince
• Original Assignee: Martin R. Prince
• Inventors: Prince, Martin R.
• Primary Examiner(s): Cohen, Lee S.
• Assistant Examiner(s): Casler, Brian L.
• Application Number:
  US08/071,970
• Time in Patent Office: 715 Days
• Field of Search: 128/653.3, 128/653.4, 128/654, 128/659, 128/655, 424/9
• US Class Current: 600/413
• CPC Class Codes: A61B 5/201 Assessing renal or kidney functions
• CPC Class Codes: A61B 5/411 Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance
• CPC Class Codes: A61B 5/416 the spleen
• CPC Class Codes: A61B 5/7285 for synchronising or triggering a physiological measurement or image acquisition with a physiological event or waveform, e.g. an ECG signal A61B6/5205, A61B6/541, A61B8/5207, A61B8/543 take precedence
• CPC Class Codes: A61K 49/18 characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
• CPC Class Codes: G01R 33/281 Means for the use of in vitro contrast agents G01R33/282 takes precedence; involving use of a contrast agent in MR imaging G01R33/5601; in vivo contrast agents A61K49/0002
• CPC Class Codes: G01R 33/5601 involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
• CPC Class Codes: G01R 33/5619 by temporal sharing of data, e.g. keyhole, block regional interpolation scheme for k-Space [BRISK]
• CPC Class Codes: G01R 33/563 of moving material, e.g. flow contrast angiography
• CPC Class Codes: G01R 33/56308 Characterization of motion or flow; Dynamic imaging

Abstract

This invention is a method of imaging arteries distinctly from veins using nuclear magnetic resonance imaging in combination with intravenous administration of an magnetic resonance contrast agent. The contrast agent is intravenously injected in such a way that the arterial contrast concentration is substantially higher than the venous and background tissue concentration for a sufficiently long period of time to acquire the magnetic resonance image. The injection site of the contrast agent is chosen such that it is in a vein which is remote from the artery of interest. The magnetic resonance contrast agent may be intravenously infused at a variable infusion rate.

Claims

1. A method of imaging an artery in a patient using magnetic resonance imaging, comprising,

collecting image data;

and

administering a magnetic resonance contrast agent to the patient, by intravenous infusion during collection of magnetic resonance image data including data representing at least a portion of the artery and at an infusion rate including a maximum which occurs during collection of image data which corresponds to a center of k-space.

2. The method of claim 1 wherein the step of administering a magnetic resonance contrast agent includes administering the contrast agent at a variable rate during collection of image data.

3. The method of claim 2 wherein the step of administering a magnetic resonance contrast agent includes administering the contrast agent substantially throughout collection of image data.

4. The method of claim 1 wherein the magnetic resonance contrast agent is a paramagnetic contrast agent having a relaxivity.

5. The method of claim 4 wherein the infusion rate is greater than 0.0015 liters/kilogram-second² divided by the relaxivity of the paramagnetic contrast agent.

6. The method of claim 4 wherein the infusion rate is greater than 0.0025 liters/kilogram-second² divided by the relaxivity of the paramagnetic contrast agent.

7. The method of claim 4 wherein the step of administering a magnetic resonance contrast agent includes administering the contrast agent so that the concentration of the contrast agent in the artery is substantially higher than the concentration of the contrast agent in the adjacent veins during collection of image data.

8. The method of claim 7 wherein the step of administering a magnetic resonance contrast agent includes administering the contrast agent so that the concentration of the contrast agent in the arteries is sufficient to induce proton nuclear magnetic relaxation of blood with a longitudinal relaxation time (T1) of less than 270 milliseconds.

9. The method of claim 4 wherein the paramagnetic contrast agent is a gadolinium chelate.

10. The method of claim 9 wherein a dose of the gadolinium chelate is within the range of 0.05 millimoles/kilogram body weight to 0.7 millimoles/kilogram body weight.

11. The method of claim 9 wherein a dose of the gadolinium chelate is within the range of 0.15 millimoles/kilogram body weight to 0.35 millimoles/kilogram body weight.

12. The method of claim 1 wherein the step of administering a magnetic resonance contrast agent includes administering the contrast agent to allow redistribution of the contrast agent into the extravascular fluid compartment in the systemic capillary bed distal to the artery so that, during collection of the image data, the concentration of magnetic resonance contrast agent in the adjacent veins is significantly lower than the concentration of magnetic resonance contrast agent in the artery.

13. The method of claim 1 wherein the step of administering magnetic resonance contrast agent includes administering contrast agent to allow the contrast agent to be altered in the systemic capillary bed distal to the artery of interest such that the contrast agent has a lower relaxivity.

14. The method of claim 1 wherein the step of administering a magnetic resonance contrast agent includes administering the contrast agent manually through a fluid flow restrictor.

15. The method of claim 14 wherein the fluid flow restrictor is coupled to a vessel containing the magnetic resonance contrast agent and wherein the step of administering a contrast agent includes administering the contrast agent in the vessel to the patient.

16. The method of claim 1 wherein the step of administering a magnetic resonance contrast agent includes administering the contrast agent using a mechanical injector.

17. The method of claim 1 wherein the step of administering a magnetic resonance contrast agent includes administering the contrast agent using a mechanical injector which is adapted to receive a vessel containing the magnetic resonance contrast agent.

18. The method of claim 1 wherein the step of administering a magnetic resonance contrast agent includes administering the contrast agent using a mechanical injector which is coupled to a vessel containing said magnetic resonance contrast agent.

19. The method of claim 1 wherein the artery is the aorta or other peripheral artery.

20. The method of claim 1 wherein said magnetic resonance contrast agent is a paramagnetic contrast agent and the step of collecting image data includes using a 3D gradient echo pulse sequence.

21. The method of claim 1 wherein said magnetic resonance contrast agent is a paramagnetic contrast agent and TE is such that fat and water are out of phase.

22. The method of claim 1 wherein the step of collecting image data includes collecting image data representing a first image and, during the step of administering a magnetic resonance contrast agent, collecting image data representative of a second image wherein a final image is enhanced by subtracting the first image from the second image.

23. The method of claim 1 further including applying EKG gating during collection of image data to reduce cardiac motion artifacts.

24. The method of claim 1 further including applying respiratory compensation during collection of image data to reduce respiratory motion artifacts.

25. The method of claim 1 further including premedicating the patient before collection of image data to reduce the heart rate, the respiratory rate, or the cardiac output.

26. The method of claim 1 wherein the step of administering a magnetic resonance contrast agent includes administering the contrast agent in a vein remote from the artery.

27. The method of claim 1 wherein the magnetic resonance contrast agent is a paramagnetic contrast agent and TR≦

30 milliseconds and flip angle is between 20°

to 90°

.

28. The method of claim 1 wherein the step of administering a magnetic resonance contrast agent includes administering the contrast agent using a mechanical injector which is spring-loaded, pneumatic powered, or electrically powered.

29. A method of imaging an artery in a patient using magnetic resonance imaging, comprising,

collecting image data;

and

administering a gadolinium chelate, having a relaxivity to the patient by substantially continuous intravenous infusion throughout collection of image data including data representing at least a portion of the artery and at an infusion rate which is greater than 0.0015 liters/kilogram-second² divided by the relaxivity of the gadolinium chelate and which includes a maximum rate of infusion which temporally correlates with the collection of image data which corresponds to a center of k-space.

30. The method of claim 29 wherein the step of administering a gadolinium chelate includes administering the gadolinium chelate manually through a fluid flow restrictor.

31. The method of claim 29 wherein the step of administering a gadolinium chelate includes administering the gadolinium chelate manually through a fluid flow restrictor which is coupled to a vessel containing the gadolinium chelate.

32. The method of claim 29 wherein the step of administering a gadolinium chelate includes administering the gadolinium chelate using a mechanical injector.

33. The method of claim 29 wherein the step of administering a gadolinium chelate includes administering the gadolinium chelate using a mechanical injector which is adapted to receive a vessel containing the gadolinium chelate.

34. The method of claim 29 wherein the step of administering a gadolinium chelate includes administering the gadolinium chelate using a mechanical injector which is coupled to a vessel containing the gadolinium chelate.

35. An infusion apparatus for infusing a magnetic resonance contrast agent into a vein of a patient, during collection of image data by a magnetic resonance imaging unit, to enhance a magnetic resonance image of an artery of said patient, the infusion apparatus comprising:

a pump, the pump adapted to receive the magnetic resonance contrast agent and adapted to administer the contrast agent to the patient, the pump includes means for controlling the rate of infusion of the magnetic resonance contrast agent into the vein, and means for matching the injection rate with the mapping of K space such that a maximum rate of infusion temporally correlates with the collection of image data which corresponds to a center of k-space.

36. The apparatus of claim 35 wherein the pump is spring-loaded, pneumatic powered, or electrically powered.

37. A method of imaging an artery in a patient using magnetic resonance imaging, comprising,

collecting image data;

and

administering a magnetic resonance contrast agent to the patient, by intravenous infusion, substantially throughout collection of image data including data representing at least a portion of the artery and at an infusion rate having a maximum occurring during collection of image data which corresponds to a center of k-space.

38. The method of claim 37 wherein the step of administering magnetic resonance contrast agent includes administering the magnetic resonance contrast agent in a vein remote from the artery.

39. The method of claim 38 wherein the magnetic resonance contrast agent is a paramagnetic contrast agent having a relaxivity.

40. The method of claim 39 wherein the infusion rate is greater than 0.0015 liters/kilogram-second² divided by the relaxivity of the paramagnetic contrast agent.

41. The method of claim 39 wherein the infusion rate is greater than 0.0025 liters/kilogram-second² divided by the relaxivity of the paramagnetic contrast agent.

42. The method of claim 37 wherein the step of administering a magnetic resonance includes administering the contrast agent so that the concentration of the contrast agent in the artery is substantially higher than the concentration of the contrast agent in the adjacent veins.

43. The method of claim 37 wherein the step of administering a magnetic resonance contrast agent includes administering the contrast agent so that the contrast agent concentration in the arteries is sufficient to induce proton nuclear magnetic relaxation of blood with a longitudinal relaxation time (T1) of less than 270 milliseconds.

44. The method of claim 37 wherein the magnetic resonance contrast agent is a gadolinium chelate.

45. The method of claim 44 wherein the step of administering a magnetic resonance contrast agent includes administering a dose of the gadolinium chelate which is within the range of 0.05 millimoles/kilogram body weight to 0.7 millimoles/kilogram body weight.

46. The method of claim 44 wherein the step of administering a magnetic resonance contrast agent includes administering a dose of the gadolinium chelate which is within the range of 0.15 millimoles/kilogram body weight to 0.35 millimoles/kilogram body weight.

47. A method of imaging an artery in a patient using magnetic resonance imaging, comprising,

collecting image data;

and

administering a magnetic resonance contrast agent to the patient, by intravenous infusion, during collection of image data including data representing at least a portion of the artery and at an infusion rate sufficient to provide a concentration of the contrast agent in the artery which is substantially higher than the concentration of the contrast agent in veins adjacent to the artery during collection of image data which corresponds to a center of k-space.

48. The method of claim 47 wherein the magnetic resonance contrast agent is administered substantially throughout collection of the image data.

49. The method of claim 47 wherein the magnetic resonance contrast agent is a paramagnetic contrast agent.

50. The method of claim 49 wherein the paramagnetic contrast agent is a gadolinium chelate.

51. The method of claim 50 wherein the step of administering a magnetic resonance contrast agent includes administering a dose of the gadolinium chelate which is within the range of 0.05 millimoles/kilogram body weight to 0.7 millimoles/kilogram body weight.

52. The method of claim 50 wherein the step of administering a magnetic resonance contrast agent includes administering a dose of the gadolinium chelate which is within the range of 0.15 millimoles/kilogram body weight to 0.35 millimoles/kilogram body weight.

53. The method of claim 47 wherein the magnetic resonance contrast agent is a gadolinium chelate which is administered substantially throughout collection of the image data in a vein remote from the artery.

54. The method of claim 47 wherein the step of administering a magnetic resonance contrast agent includes administering the contrast agent so that the contrast agent is capable of being altered in the systemic capillary bed distal to the artery of interest such that the contrast agent has a lower relaxivity.

55. The method of claim 47 wherein the step of administering a magnetic resonance contrast agent includes administering the contrast agent manually through a fluid flow restrictor.

56. The method of claim 47 wherein the step of administering a magnetic resonance contrast agent includes administering the contrast agent using a mechanical injector.

57. The method of claim 47 wherein the step of administering a magnetic resonance contrast agent includes administering the contrast agent using a mechanical injector which is spring-loaded, pneumatic powered, or electrically powered.

58. The method of claim 47 wherein the artery is the aorta or other peripheral artery.

59. The method of claim 47 wherein the step of collecting image data includes collecting image data representing a first image before intravenous infusion of the magnetic resonance contrast agent and, during the step of administering the magnetic resonance contrast agent, collecting image data representing a second image.

60. The method of claim 47 further including applying EKG gating during collection of image data to reduce cardiac motion artifacts.

61. The method of claim 47 further including applying respiratory compensation during collection of image data to reduce respiratory motion artifacts.

62. The method of claim 47 further including premedicating the patient before collection of image data to reduce the heart rate, the respiratory rate, or the cardiac output.

63. A method of imaging an artery in a patient using magnetic resonance imaging, comprising,

collecting image data;

and

administering a paramagnetic contrast agent to the patient, by intravenous infusion, during collection of image data including data representing at least a portion of the artery and at an infusion rate having a maximum which temporally correlates to the collection of image data which corresponds to a center of k-space.

64. The method of claim 63 wherein the paramagnetic contrast agent is a gadolinium chelate.

65. The method of claim 64 wherein the step of collecting image data includes collecting a first image data set representing a first image and, during the step of administering a paramagnetic contrast agent, collecting a second image data set representative of a second image, and wherein the method of imaging an artery further includes generating a third image data set using the first image data set and the second image data set.

66. The method of claim 64 wherein the step of administering a paramagnetic contrast agent includes administering the contrast agent using a mechanical injector which is spring-loaded, pneumatic powered, or electrically powered.