Magnetic resonance arteriography with dynamic intravenous contrast agents
First Claim
1. A method of imaging an artery in a patient using magnetic resonance imaging, comprising,collecting image data;
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Abstract
This invention is a method of imaging arteries distinctly from veins using nuclear magnetic resonance imaging in combination with intravenous administration of an magnetic resonance contrast agent. The contrast agent is intravenously injected in such a way that the arterial contrast concentration is substantially higher than the venous and background tissue concentration for a sufficiently long period of time to acquire the magnetic resonance image. The injection site of the contrast agent is chosen such that it is in a vein which is remote from the artery of interest. The magnetic resonance contrast agent may be intravenously infused at a variable infusion rate.
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Citations
66 Claims
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1. A method of imaging an artery in a patient using magnetic resonance imaging, comprising,
collecting image data; - and
administering a magnetic resonance contrast agent to the patient, by intravenous infusion during collection of magnetic resonance image data including data representing at least a portion of the artery and at an infusion rate including a maximum which occurs during collection of image data which corresponds to a center of k-space. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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29. A method of imaging an artery in a patient using magnetic resonance imaging, comprising,
collecting image data; - and
administering a gadolinium chelate, having a relaxivity to the patient by substantially continuous intravenous infusion throughout collection of image data including data representing at least a portion of the artery and at an infusion rate which is greater than 0.0015 liters/kilogram-second2 divided by the relaxivity of the gadolinium chelate and which includes a maximum rate of infusion which temporally correlates with the collection of image data which corresponds to a center of k-space. - View Dependent Claims (30, 31, 32, 33, 34)
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35. An infusion apparatus for infusing a magnetic resonance contrast agent into a vein of a patient, during collection of image data by a magnetic resonance imaging unit, to enhance a magnetic resonance image of an artery of said patient, the infusion apparatus comprising:
a pump, the pump adapted to receive the magnetic resonance contrast agent and adapted to administer the contrast agent to the patient, the pump includes means for controlling the rate of infusion of the magnetic resonance contrast agent into the vein, and means for matching the injection rate with the mapping of K space such that a maximum rate of infusion temporally correlates with the collection of image data which corresponds to a center of k-space. - View Dependent Claims (36)
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37. A method of imaging an artery in a patient using magnetic resonance imaging, comprising,
collecting image data; - and
administering a magnetic resonance contrast agent to the patient, by intravenous infusion, substantially throughout collection of image data including data representing at least a portion of the artery and at an infusion rate having a maximum occurring during collection of image data which corresponds to a center of k-space. - View Dependent Claims (38, 39, 40, 41, 42, 43, 44, 45, 46)
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47. A method of imaging an artery in a patient using magnetic resonance imaging, comprising,
collecting image data; - and
administering a magnetic resonance contrast agent to the patient, by intravenous infusion, during collection of image data including data representing at least a portion of the artery and at an infusion rate sufficient to provide a concentration of the contrast agent in the artery which is substantially higher than the concentration of the contrast agent in veins adjacent to the artery during collection of image data which corresponds to a center of k-space. - View Dependent Claims (48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62)
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63. A method of imaging an artery in a patient using magnetic resonance imaging, comprising,
collecting image data; - and
administering a paramagnetic contrast agent to the patient, by intravenous infusion, during collection of image data including data representing at least a portion of the artery and at an infusion rate having a maximum which temporally correlates to the collection of image data which corresponds to a center of k-space. - View Dependent Claims (64, 65, 66)
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Specification