Solid state ion sensor with polyimide membrane

• US 5,417,835 A
• Filed: 10/14/1993
• Issued: 05/23/1995
• Est. Priority Date: 06/23/1989
• Status: Expired due to Fees

• Current Assignee: Board of Regents of the University of Michigan (University of Michigan)
• Original Assignee: Board of Regents of the University of Michigan (University of Michigan)
• Inventors: Cha, Geun-Sig, Brown, Richard B.
• Primary Examiner(s): Gorgos, Kathryn
• Assistant Examiner(s): Leader, William T.
• Application Number:
  US08/137,373
• Time in Patent Office: 586 Days
• Field of Search: 204/418, 204/416, 204/403, 257/253, 257/414, 435/288, 435/291, 435/817
• US Class Current: 204/403.06
• CPC Class Codes: G01N 27/3335 the membrane containing at least one organic component G01N27/3271 takes precedence; aspects concerning the enzyme reagent in enzyme electrodes C12Q1/001
• CPC Class Codes: Y10S 435/817 Enzyme or microbe electrode

Abstract

A polyimide matrix is employed to form a substance-sensitive membrane which is particularly suited for installation on a solid state sensor. Polyimide, dissolved in a solvent, such as N,N-dimethylformamide, or N-methyl-2-pyrrolidone (polyimide encapsulant), is combined with an ionophore, plasticizer, and a lipophilic additive. The ionophore may be a calcium ionophore, an ammonium ionophore, or any other ionophore. The membrane may also incorporate, or may be covered by, a bioactive agent, such as an enzyme, an immunochemical, bacteria, antibody, virus, or antigen. The plasticizer is one or both of dimethyl phthalate and diethylene glycol dibenzoate. The lipophilic additive may be potassium tetrakis(p-chlorophenyl)borate. The resulting substance-sensitive membrane has electrochemical properties which compare favorably to those of conventional PVC membranes, and exhibit significantly greater adhesion to glasses and semiconductor substrate materials. The improved adhesion may prolong the life of the sensors and prevent the formation of electrolyte shunts which have been known to render solid state sensors inoperative.

Claims

1. An integrated circuit chemical sensor arrangement comprising:

an input electrode formed of a conductive material in the vicinity of a region formed of a silicon-based semiconductor material; and

a permselective membrane having an ion-selective electrochemical property and formed by dissolving a polyimide-based compound in a solvent with a plasticizer selected from the group consisting of dimethy phthalate (DMP) and diethylene glycol dibenzoate LDGD), and a neutral carrier ionophore and then removing said solvent, whereby said plasticizer and said neutral carder ionophore are uniformly distributed in said polyimide-based compound, said permselective membrane being arranged to be in adherence with said silicon-based semiconductor material and in electrical communication with said input electrode, for producing at said input electrode a voltage responsive to said electrochemical property, whereby said permselective membrane is formed of solidified polyimide.

2. The integrated circuit chemical sensor arrangement of claim 1 wherein said polyimide-based compound in said permselective membrane is made from a polyimide powder.

3. The integrated circuit chemical sensor arrangement of claim 2 wherein said solvent is N,N-dimethylformamide (DMF).

4. The integrated circuit chemical sensor arrangement of claim 2 wherein said permselective membrane is further comprised of a lipophilic additive.

5. The integrated circuit chemical sensor arrangement of claim 4 wherein said lipophilic additive is potassium tetrakis (p-chlorophenyl) borate.

6. The integrated circuit chemical sensor arrangement of claim 1 wherein said neutral carrier ionophore renders the integrated circuit chemical sensor arrangement responsive to calcium.

7. The integrated circuit chemical sensor arrangement of claim 1 wherein said sensor is responsive to a bioactive agent.

8. The integrated circuit chemical sensor arrangement of claim 7 wherein said bioactive agent is selected from the group consisting of an enzyme, an immunochemical, a bacteria, and a virus.

9. The integrated circuit chemical sensor arrangement of claim 1 wherein said permselective membrane is comprised of a material which has been subjected to imidization.

10. The integrated circuit chemical sensor arrangement of claim 9 wherein said preimidized material is pyralin LTP.

11. The integrated circuit chemical sensor arrangement of claim 9 wherein said permselective membrane is further comprised of a lipophilic additive.

12. The integrated circuit chemical sensor arrangement of claim 11 wherein said lipophilic additive is potassium tetrakis (p-chlorophenyl) borate.

13. The integrated circuit chemical sensor arrangement of claim 1 wherein said plasticizer is dipentyl phthalate.