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Vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres

  • US 5,417,986 A
  • Filed: 04/10/1992
  • Issued: 05/23/1995
  • Est. Priority Date: 03/16/1984
  • Status: Expired due to Fees
First Claim
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1. An immunostimulating composition comprising encapsulation-microspheres, which may contain a pharmaceutically-acceptable adjuvant, wherein said microspheres having a diameter between 1 nanometers (nm) to 10 microns (um) are comprised of (a) a biodegradable-biocompatible poly (DL-lactide-co-glycolide) or polyglycolide as the bulk matrix, wherein the relative ratio between the amount of lactide;

  • glycolide components are within the range of 52;

    48 to 0;

    100 and (b) an immunogenic substance comprising Colonization Factor Antigen and hepatitis B surface antigen that serves to elicit the production of antibodies and T-lymphocyte proliferation in animals.

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