Autonomic nervous system testing by bi-variate spectral analysis of heart period and QT interval variability

• US 5,419,338 A
• Filed: 02/22/1994
• Issued: 05/30/1995
• Est. Priority Date: 02/22/1994
• Status: Expired due to Term

• Current Assignee: City of Hope
• Original Assignee: City of Hope
• Inventors: Venkataraman, Kalyanasundaram, Sarma, Jonnalagedda S. M.
• Primary Examiner(s): Kamm, William E.
• Application Number:
  US08/199,689
• Time in Patent Office: 462 Days
• Field of Search: 128/702, 128/703, 128/705
• US Class Current: 600/516
• CPC Class Codes: A61B 5/349 Detecting specific parameters of the electrocardiograph cycle
• CPC Class Codes: A61B 5/36 Detecting PQ interval, PR interval or QT interval
• CPC Class Codes: A61B 5/364 Detecting abnormal ECG interval, e.g. extrasystoles, ectopic heartbeats
• CPC Class Codes: A61B 5/4035 Evaluating the autonomic nervous system
• CPC Class Codes: G16H 15/00 ICT specially adapted for medical reports, e.g. generation or transmission thereof

Abstract

Apparatus and method for testing the autonomic nervous system of a mammal through bi-variate analysis of heart period (RR) and QT interval variability obtained through data processing of electrocardiographic data. The method and apparatus enables both the parasympathetic and sympathetic controls on the heart to be evaluated for imbalances therebetween, which may indicate a predisposition for sudden cardiac death.

Claims

1. A method for testing the autonomic nervous system of a mammal, comprising the steps of:

obtaining electrocardiographic (ECG) data from said mammal under a selectable state of autonomic stimulation for a predetermined period of time;

calculating heart period (RR) intervals and QT intervals for a predetermined number of heart beats represented in said ECG data, and outputting the calculated RR and QT intervals in the form of electrical data signals;

calculating power spectral densities of said RR and QT intervals; and

analyzing the calculated RR and QT interval power spectral densities with respect to each other as an indication of the state of balance between parasympathetic and sympathetic controls of the autonomic nervous system of said mammal.

2. A method for testing the autonomic nervous system of a mammal as set forth in claim 1, wherein the step of calculating RR and QT intervals comprises the step of measuring QT intervals from the beginning of a QRS complex in said ECG data to the apex of a succeeding T wave.

3. A method for testing the autonomic nervous system of a mammal as set forth in claim 1, wherein the step of calculating RR and QT intervals comprises the step of measuring QT intervals from the beginning of a QRS complex in said ECG data to the terminal portion of a succeeding T wave in said ECG data.

4. A method for testing the autonomic nervous system of a mammal as set forth in claim 3, further comprising the step of calculating said terminal portion of said T wave through linear regression analysis.

5. A method for testing the autonomic nervous system of a mammal as set forth in claim 1, wherein the step of calculating power spectral densities comprises the step of performing fast Fourier analysis on said calculated RR and QT intervals.

6. A method for testing the autonomic nervous system of a mammal, comprising the steps of:

obtaining electrocardiographic (ECG) data from said mammal under a selectable state of autonomic stimulation for a predetermined period of time;

calculating heart period (RR) intervals and QT intervals for a predetermined number of heart beats represented in said ECG data, and outputting the calculated RR and QT intervals in the form of electrical data signals; and

analyzing the calculated RR and QT intervals with respect to each other as an indication of the state of balance between parasympathetic and sympathetic controls of the autonomic nervous system of said mammal.

7. A method for testing the autonomic nervous system of a mammal as set forth in claim 6, wherein said predetermined period of time comprises a 24 hour period, and said step of analyzing comprises the steps of outputting said electrical data signals in the form of circadian patterns and performing analysis of circadian variation of said calculated RR and QT intervals with respect to each other.

8. A method for testing the autonomic nervous system of a mammal as set forth in claim 6, wherein the step of calculating RR and QT intervals comprises the step of measuring QT intervals from the beginning of a QRS complex in said ECG data to the apex of a succeeding T wave.

9. A method for testing the autonomic nervous system of a mammal as set forth in claim 6, wherein the step of calculating RR and QT intervals comprises the step of measuring QT intervals from the beginning of a QRS complex in said ECG data to the terminal portion of a succeeding T wave in said ECG data.

10. Apparatus for testing the autonomic nervous system of a mammal, comprising:

means for obtaining electrocardiographic (ECG) data from said mammal under a selectable state of autonomic stimulation for a predetermined period of time;

means for calculating heart period (RR) intervals and QT intervals for a predetermined number of heart beats represented in said ECG data, and for outputting the calculated RR and QT intervals in the form of electrical data signals;

means for calculating power spectral densities of said RR and QT intervals; and

means for analyzing the calculated RR and QT interval power spectral densities with respect to each other as an indication of the state of balance between parasympathetic and sympathetic controls of the autonomic nervous system of said mammal.

11. Apparatus for testing the autonomic nervous system of a mammal as set forth in claim 10, wherein said means for calculating RR and QT intervals measures QT intervals from the beginning of a QRS complex in said ECG data to the apex of a succeeding T wave.

12. Apparatus for testing the autonomic nervous system of a mammal as set forth in claim 10, wherein said means for calculating RR and QT intervals measures QT intervals from the beginning of a QRS complex in said ECG data to the terminal portion of a succeeding T wave in said ECG data.

13. Apparatus for testing the autonomic nervous system of a mammal as set forth in claim 12, further comprising means for calculating said terminal portion of said T wave through linear regression analysis.

14. Apparatus for testing the autonomic nervous system of a mammal as set forth in claim 10, wherein said means for calculating power spectral densities comprises means for performing fast Fourier analysis on said calculated RR and QT intervals.

15. Apparatus for testing the autonomic nervous system of a mammal as set forth in claim 10, wherein said means for obtaining electrocardiographic (ECG) data comprises a magnetic tape recorder/player.

16. Apparatus for testing the autonomic nervous system of a mammal as set forth in claim 10, wherein said means for obtaining electrocardiographic (ECG) data comprises a 24 hour ambulatory ECG recorder.

17. Apparatus for testing the autonomic nervous system of a mammal as set forth in claim 10, wherein said means for calculating heart period (RR) intervals and QT intervals comprises a waveform analyzer.

18. Apparatus for testing the autonomic nervous system of a mammal as set forth in claim 10, wherein said means for calculating power spectral densities of said RR and QT intervals comprises a programmed personal computer.