Calibration system and housing

• US 5,420,038 A
• Filed: 12/17/1993
• Issued: 05/30/1995
• Est. Priority Date: 04/26/1990
• Status: Expired due to Fees

• Current Assignee: Terumo Cardiovascular Systems Corporation (Terumo Corporation)
• Original Assignee: 3M Company
• Inventors: Maxwell, Thomas P., Wall, Roxanne E.
• Primary Examiner(s): ALEXANDER, LYLE
• Application Number:
  US08/169,154
• Time in Patent Office: 529 Days
• Field of Search: 436/8, 436/11, 422/68.1, 422/81, 422/102, 422/103, 128/DIG. 12, 128/DIG. 13
• US Class Current: 436/8
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: B01F 25/4522 the components being pressed through porous bodies, e.g. flat plates, blocks or cylinders, which obstruct the whole diameter of the tube B01F25/45243 takes precedence
• CPC Class Codes: G01N 27/4163 checking the operation of, or calibrating, the measuring apparatus G01N27/3274, G01N27/4175 and G01N33/0006 take precedence
• CPC Class Codes: G01N 27/4165 for pH meters
• CPC Class Codes: Y10S 128/12 Pressure infusion
• CPC Class Codes: Y10S 128/13 Infusion monitoring
• CPC Class Codes: Y10T 436/10 Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
• CPC Class Codes: Y10T 436/102499 Blood gas standard or control

Abstract

A calibration system comprising a sensor cassette including at least one sensor to be calibrated and a housing having a liquid passage including a chamber. The housing is coupled to the sensor cassette to place the liquid passage in fluid communication with the sensor cassette. The housing has a gas injection passage through which a gas can be injected into the liquid passage to mix with a calibration liquid in the housing. A gas vent vents the gas from the housing. Porous media is provided in the chamber. The gas and calibration liquid pass through the porous media, and the porous media assists in rapid mixing of the gas and the calibration liquid.

Claims

1. A calibration housing for use in calibrating a sensor responsive to a characteristic of a gas, said calibration housing comprising:

an enclosure having a liquid inlet, a liquid outlet and a liquid passage extending between the liquid inlet and the liquid outlet, said liquid passage including a permeable portion which is at least somewhat permeable to at least one of the gas and a component of air;

said liquid passage including a sparging chamber section, a settling chamber section, and an inlet section leading from the liquid inlet to the sparging chamber section, said enclosure including a dividing wall between the sparging chamber section and the settling chamber section;

a gas injection passage for use in injecting a gas into the inlet section of the liquid passage section;

a gas vent leading from the settling chamber section, said liquid outlet leading from the settling chamber section whereby gas and liquid received by the settling chamber section from the sparging chamber section can pass out the gas vent and the liquid outlet, respectively; and

a barrier coated on said permeable portion which is less permeable than said permeable portion to said one of the gas and said component of air, said barrier also serving to reduce any mass transfer between said permeable portion and liquid therewithin and between said permeable portion and said gas.

2. A calibration housing as defined in claim 1 wherein said permeable portion is at least somewhat permeable to at least one of oxygen and carbon dioxide.

3. A calibration housing as defined in claim 1 wherein said barrier comprises polyxylylene.

4. A calibration housing as defined in claim 1 wherein said barrier comprises Parylene C.

5. A calibration housing as defined in claim 1 wherein said permeable portion comprises silicone.

6. A calibration housing as defined in claim 5 wherein said barrier comprises polyxylylene.

7. A calibration housing as defined in claim 1 including a pump in said enclosure for pumping liquid through the liquid passage, said pump having a liquid path therethrough which forms a portion of the inlet section of the liquid passage.

8. A calibration housing as defined in claim 7 wherein the gas injection passage and the inlet section of the liquid passage meet at a location downstream of the pump and upstream of the sparging chamber section.

9. A calibration housing as defined in claim 7 wherein the pump is a peristaltic pump having a radially compressible tube having an interior surface defining a passage which forms a portion of the inlet section of the liquid passage, said permeable portion including at least a portion of said compressible tube.

10. A calibration housing as defined in claim 1 further comprising a porous media in said sparging chamber section through which liquid and gas from the inlet section of the liquid passage can pass to assist in mixing of the gas and liquid.

11. A calibration housing as defined in claim 10 including second porous media in the settling chamber for reducing the likelihood of liquid passing through the gas vent.

12. A calibration housing as defined in claim 10 wherein the porous media includes an open cell polymeric foam.

13. A calibration housing as defined in claim 12 wherein the foam has from about 3 to about 45 pores per inch and at least about 20 percent open volume.

14. A calibration housing as defined in claim 12 wherein the foam has from about 3 to about 7 pores per inch and at least about 85 percent open volume.

15. A calibration housing as defined in claim 12 further comprising a barrier coated on the foam to reduce any mass transfer between the foam and the liquid and between the foam and the gas.

16. A calibration housing as defined in claim 15 wherein the foam has from about 3 to about 7 pores per inch and at least about 85 percent open volume.

17. A calibration system comprising:

at least one sensor to be calibrated, said sensor being responsive to a characteristic of a gas;

a housing having a liquid inlet, a liquid outlet and a liquid passage extending between the liquid inlet and the liquid outlet;

conduit means for coupling the liquid inlet and liquid outlet to the sensor;

said housing having a gas injection passage through which a gas can be injected into the liquid passage;

means for venting the gas from the housing;

at least one of said liquid passage and the conduit means including a permeable portion which is at least somewhat permeable to at least one of the gas and a component of air; and

a barrier coated on said permeable portion which is less permeable than said permeable portion to said one of the gas and said component of air, said barrier also serving to reduce any mass transfer between said permeable portion and liquid therewithin and between said permeable portion and said gas.

18. A calibration system as defined in claim 17 wherein said permeable portion is at least somewhat permeable to at least one of oxygen and carbon dioxide.

19. A calibration system as defined in claim 17 including a peristaltic pump in said housing for pumping liquid through the housing, said pump including a radially compressible tube having a passage which forms a portion of the liquid passage and said permeable portion includes at least a portion of said tube.

20. A calibration system as defined in claim 17 wherein the conduit means includes a first relatively soft and deformable section coupled to the housing and a second section which is less soft and less deformable than the first section coupled to the first section and to the sensor, and said permeable portion includes at least a portion of said first section.

21. A calibration system as defined in claim 17 wherein said barrier comprises polyxylylene.

22. A calibration system as defined in claim 17 wherein said barrier comprises Parylene C.

23. A calibration system as defined in claim 17 wherein said permeable portion comprises silicone.

24. A calibration system as defined in claim 23 wherein said barrier comprises polyxylylene.

25. A calibration system as defined in claim 17 further comprising an open cell foam positioned in said liquid passage.

26. A calibration system as defined in claim 25 wherein said open cell foam has from about 3 to about 7 pores per inch and at least about 85 percent open volume.

27. A calibration system as defined in claim 26 further comprising a barrier coated on the open cell foam to reduce any mass transfer between the open cell foam and the liquid and between the open cell foam and the gas.