Method of controlling diabetes mellitus

• US 5,420,108 A
• Filed: 09/14/1992
• Issued: 05/30/1995
• Est. Priority Date: 09/14/1992
• Status: Expired due to Term

• Current Assignee: Isaac H. Shohet
• Original Assignee: Isaac H. Shohet
• Inventors: Shohet, Isaac H.
• Primary Examiner(s): Warden, Jill
• Assistant Examiner(s): DAVENPORT, AVIS MICHELLE
• Application Number:
  US07/943,176
• Time in Patent Office: 988 Days
• Field of Search: 514/3, 514/4, 514/12, 530/300, 530/303, 530/324
• US Class Current: 514/6.5
• CPC Class Codes: A61K 38/28 Insulins

Abstract

The use of precise dosages of insulin-plus-sugar in a method of controlling and/or treating diabetes is disclosed, including the steps of frequently testing both the blood sugar level and the urine sugar level of the diabetic patient; and administering insulin and/or sugar as required by the results of the blood and urine sugar tests. The amount of insulin and/or sugar administered is reviewed daily and modifications are made on a daily basis such that the patient over time will need little or no insulin. The present invention is also related to a method for controlling the out-of-control diabetic patient and to a method for reversing the negative effects already caused by diabetes. This method also avoids the side effects of insulin use such as hypoglycemia and hyperinsulinemia.

Claims

1. A method for controlling diabetes mellitus in a diabetic patient, comprising

(a) testing both the blood sugar level and the urine sugar level of the diabetic patient;

(b) administering insulin before a meal and sugar after a meal as required by the results of the blood and urine sugar tests; and

(c) repeating steps (a) and (b) as needed;

wherein the amount of insulin and sugar administered is adjusted daily based on the blood sugar and urine sugar test results to control diabetes mellitus in the diabetic patient

(d) increasing the insulin dosage as necessary from the response of the patient to blood and urine sugar content of the patient until a urine sugar level below 2% is reached; and

decreasing the insulin dosage until a negative urine sugar level content is achieved.

2. The method of claim 1, wherein the blood and urine sugar levels are tested seven times a day.

3. The method of claim 2, wherein the blood and urine sugar levels are tested before each meal, two hours after each meal and at bedtime.

5. The method of claim 2, wherein the sugar administered is a simple sugar.

4. A method for controlling diabetes mellitus in a diabetic patient, comprising

(a) testing both the blood sugar level and the urine sugar level of the diabetic patient seven times a day;

(b) administering an amount of insulin and sugar supplementation after an initial administration to reach a maximized need, then, in steadily decreasing dosages, decreasing the insulin to about one unit less per dose than the amount which would induce insulin-induced hypoglycemia; and

the sugar supplementation is decreased so as to avoid sugar-induced hyperglycemia;

(c) continuing the reduction in sugar and insulin dose as needed by results of blood and sugar urine tests until the diabetic patient requires no insulin or sugar, and the urine sugar tests will be negative and the blood sugar tests will be about normal.

6. A method for reducing or eliminating the dependency of a diabetic patient whose diabetes is out-of-control on administered insulin, comprising

administering insulin to an out-of-control diabetic patient;

increasing the insulin dosage as necessary from the response of the patient to blood and urine sugar tests to a maximum while monitoring the blood and urine sugar content of the patient until a urine sugar level below 2% is reached; and

decreasing the insulin dosage until a negative urine sugar level content and an insulin requirement of zero is achieved;

wherein sugar is administered in relation to the insulin at dosages in which hypoglycemia is avoided while not causing hyperglycemia.

7. A method of treating a diabetic patient whose diabetes is out-of-control said patient'"'"'s pancreas being suppressed, exhausted or both comprising

administering insulin to an out-of-control diabetic patient;

increasing the insulin dosage as necessary to a maximum that is required by the patient'"'"'s progress until pancreatic activity is increased as indicated by increased production of insulin; and

reducing the dosages of administered insulin while monitoring the blood and urine sugars as the pancreas function increasingly takes over by steadily increasing its own insulin production to meet the needs of the patient.

12. A method of claim 7, wherein the administration of insulin, sugar of both proceeds according to the following:

space="preserve" listing-type="tabular">______________________________________ Test time Insulin involved ______________________________________ Before breakfast The evening NPH 2 hours after breakfast The morning regular Before lunch The morning regular 2 hours after lunch The before lunch regular and the morning NPH Before supper The morning NPH and the before lunch regular 2 hours after supper The before supper regular and the morning NPH Bedtime The before supper regular and the evening NPH. ______________________________________

16. The method of claim 12, wherein the blood and urine sugar levels are tested about seven times a day.

8. A method of treating a diabetic patient, avoiding the onset of insulin-induced hypoglycemia and thereby the damage caused by administering insulin to said diabetic patient, said method comprising

(a) testing both the blood sugar level and the urine sugar level of the diabetic patient;

(b) administering insulin before a meal and sugar after a meal as required by the results of the blood and urine sugar tests; and

(c) repeating steps (a) and (b) as needed;

wherein the amount of insulin and sugar administered is adjusted daily based on the blood sugar and urine sugar test results to avoid the onset of insulin-induced hypoglycemia in the diabetic patient

(d) increasing the insulin dosage as necessary from the response of the patient to blood and urine sugar content of the patient until a urine sugar level below 2% is reached; and

decreasing the insulin dosage until a negative urine sugar level content is achieved.

13. A method of claim 8, wherein the administration of insulin, sugar or both proceeds according to the following:

space="preserve" listing-type="tabular">______________________________________ Test time Insulin involved ______________________________________ Before breakfast The evening NPH 2 hours after breakfast The morning regular Before lunch The morning regular 2 hours after lunch The before lunch regular and the morning NPH Before supper The morning NPH and the before lunch regular 2 hours after supper The before supper regular and the morning NPH Bedtime The before supper regular and the evening NPH. ______________________________________

17. The method of claim 13, wherein the blood and urine sugar levels are tested about seven times a day.

9. A method of making diabetes mellitus progressively milder in a diabetic patient, comprising

(a) testing both the blood sugar level and the urine sugar level of the diabetic patient;

(b) administering insulin before a meal and sugar after a meal as required by the results of the blood and urine sugar tests; and

(c) repeating steps (a) and (b) as needed; and

progressively reducing both in insulin and sugar administered based on the blood and urine sugar tests as the diabetes is reduced to a progressively milder state;

wherein the amount of insulin and sugar administered is adjusted daily based on both the blood sugar and urine sugar test results to make the diabetes mellitus progressively milder

(d) increasing the insulin dosage as necessary from the response of the patient to blood and urine sugar content of the patient until a urine sugar level below 2% is reached; and

decreasing the insulin dosage until a negative urine sugar level content is achieved.

14. A method of claim 9, wherein the administration of insulin, sugar or both proceeds according to the following:

space="preserve" listing-type="tabular">______________________________________ Test time Insulin involved ______________________________________ Before breakfast The evening NPH 2 hours after breakfast The morning regular Before lunch The morning regular 2 hours after lunch The before lunch regular and the morning NPH Before supper The morning NPH and the before lunch regular 2 hours after supper The before supper regular and the morning NPH Bedtime The before supper regular and the evening NPH. ______________________________________

18. The method of claim 14, wherein the blood and urine sugar levels are tested about seven times a day.

10. A method of treating diabetes mellitus to a compensated state in a diabetic patient, comprising

(a) testing both the blood sugar level and the urine sugar level of the diabetic patient;

(b) administering insulin before a meal and sugar after a meal as required by the results of the blood and urine sugar tests; and

(c) repeating steps (a) and (b) as needed; and

wherein the amount of insulin and sugar administered is adjusted daily based on both the blood sugar and urine sugar test results to treat diabetes mellitus to a compensated state

(d) increasing the insulin dosage as necessary from the response of the patient to blood and urine sugar content of the patient until a urine sugar level below 2% is reached; and

decreasing the insulin dosage until a negative urine sugar level content and an insulin requirement of zero is achieved.

15. A method of claim 10, wherein the administration of insulin, sugar or both proceeds according to the following:

space="preserve" listing-type="tabular">______________________________________ Test time Insulin involved ______________________________________ Before breakfast The evening NPH 2 hours after breakfast The morning regular Before lunch The morning regular 2 hours after lunch The before lunch regular and the morning NPH Before supper The morning NPH and the before lunch regular 2 hours after supper The before supper regular and the morning NPH Bedtime The before supper regular and the evening NPH. ______________________________________

19. The method of claim 15, wherein the blood and urine sugar levels are tested about seven times a day.

11. A method of treating a diabetic patient, avoiding the onset of iatrogenic hyperinsulinaemia in said diabetic patient, comprising

(a) testing both the blood sugar level and the urine sugar level of the diabetic patient;

(b) administering insulin before a meal and sugar after a meal as required by the results of the blood and urine sugar tests; and

(c) repeating steps (a) and (b) as needed;

wherein the amount of insulin and sugar administered is adjusted daily based on both the blood sugar and urine sugar test results to avoid the onset of iatrogenic hyperinsulinaemia

(d) increasing the insulin dosage as necessary from the response of the patient to blood and urine sugar content of the patient until a urine sugar level below 2% is reached; and

decreasing the insulin dosage until a negative urine sugar level content and an insulin requirement of zero is achieved.