Non-intrusive analgesic neuroaugmentive and iontophoretic delivery apparatus and management system

• US 5,421,817 A
• Filed: 09/27/1993
• Issued: 06/06/1995
• Est. Priority Date: 05/21/1991
• Status: Expired due to Term

• Current Assignee: Bernard Liss, Fisher Wallace Laboratories, Saul Liss
• Original Assignee: E.P. Inc.
• Inventors: Liss, Saul, Liss, Bernard
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): Getzow, Scott M.
• Application Number:
  US08/127,163
• Time in Patent Office: 617 Days
• Field of Search: 604/20
• US Class Current: 604/20
• CPC Class Codes: A61N 1/325 for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body electrodes for external use A61N1/0428
• CPC Class Codes: A61N 1/36021 for treatment of pain

Abstract

The present invention pertains to a portable non-invasive electronic apparatus which can be used to relieve pain or alter the symptoms of certain neurological dysfunctions. A specifically contoured constant current and current limited waveform is generated and applied to selectively positioned electrodes. A program controlled processor tracks usage of the unit to prevent abuse and monitor progress. An overall treatment regimen centered on the stimulator may be effected simply and safely. The invention also provides an apparatus and method for the iontophoretic topical administration of a pharmaceutical agent. The apparatus is operated in a monopolar mode with a particular complex waveform which synergistically enhances the amount of various neurobiochemical species in the cerebral spinal fluid and the blood plasma.

Claims

1. In combination, in a system for the iontophoretic topical delivery of a pharmaceutically active agent, said system comprising:

a. means for generating a substantially constant current pulsed DC output voltage;

b. means for converting said output voltage into a double modulated output adjustable constant current waveform;

c. contact means for containing and delivering said pharmaceutically active agent to a topical area of a patient in need of treatment, said contact means including at least two electrodes;

d. means for directing said double modulated output waveform to said contact means;

wherein said double modulated output waveform comprises a first waveform component ranging between 1 Hz and 300 GHz, a second waveform component ranging between 10 and 199,000 Hz, and a third waveform component ranging between 100 Hz and 300 GHz, and each waveform component is substantially time invariant and distinct from said other waveform components, said double modulated output waveform having a monopolar characteristic.

2. The system of claim 1 wherein said first waveform component has a 50% duty cycle, and said second waveform component has a 75% duty cycle but not limited thereto.

3. The system of claim 1, wherein the first waveform component ranges from about 10 Hz to about 100 KHz.

4. The system of claim 3, wherein the first waveform component ranges from about 10-50 KHz.

5. The system of claim 4, wherein said second waveform component ranges from about 10 Hz to about 199 KHz.

6. The system of claim 1, wherein said third waveform component ranges from about 100 Hz to about 100 KHz.

7. The system of claim 1, wherein said first waveform component is approximately 15,000 Hz, said second waveform component is approximately 15 Hz, and said third waveform component is approximately 500 Hz but not limited thereto.

8. The system of claim 1, further comprising at least one additional waveform component operating at the resonant frequency of a particular tissue type, which is substantially time invariant and distinct from said other waveform components.