Device and method for iontophoretic drug delivery
First Claim
1. A device suitable for iontophoretic administration of an active agent through a body surface of a host, comprising:
- a source of current;
an active electrode element in electrical contact with the source of current and adapted to make ion-transmitting contact with the body surface, the active electrode element comprising an ionomeric layer and an overlapping carrier layer, the ionomeric layer adapted to be placed in ion-transmitting relation with the body surface, and the carrier layer being compatible with and containing the active agent in a freely mobile form, means for maintaining the carrier layer separate from the ionomeric layer so as to prevent transport of the active agent into the ionomeric layer, means enabling the carrier layer to be placed into contact with the ionomeric layer to permit transport of the active agent into the ionomeric layer; and
a counter electrode element in electrical contact with the current source and adapted to be placed in ion-transmitting relation with the body surface.
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Accused Products
Abstract
An iontophoretic device having a two-layer active electrode element is disclosed. The active element is composed of overlapping skin contact hydrogel and carrier layers. The carrier layer contains dispersed or dissolved active agent. The active electrode element maintains the active agent in stable form and permits efficient transport of the active agent to the host. Also disclosed is an iontophoretic device having a single layer active electrode element. The single layer is a hydrogel as manufactured or substantially dry and capable of being hydrated before use. The skin contact hydrogel of the two-layer active electrode element preferably.
122 Citations
44 Claims
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1. A device suitable for iontophoretic administration of an active agent through a body surface of a host, comprising:
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a source of current; an active electrode element in electrical contact with the source of current and adapted to make ion-transmitting contact with the body surface, the active electrode element comprising an ionomeric layer and an overlapping carrier layer, the ionomeric layer adapted to be placed in ion-transmitting relation with the body surface, and the carrier layer being compatible with and containing the active agent in a freely mobile form, means for maintaining the carrier layer separate from the ionomeric layer so as to prevent transport of the active agent into the ionomeric layer, means enabling the carrier layer to be placed into contact with the ionomeric layer to permit transport of the active agent into the ionomeric layer; and a counter electrode element in electrical contact with the current source and adapted to be placed in ion-transmitting relation with the body surface. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 14, 15, 16)
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12. A device suitable for iontophoretic administration of an active agent through the body surface of a host, comprising:
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a source of current; an active electrode element in electrical contact with the source of current and adapted to make ion-transmitting contact with the body surface, the active electrode element comprising a ionomeric layer and an overlapping carrier layer, the ionomeric layer being adapted to be placed in ion-transmitting relation with the body surface, and being comprised of an ionic organic polymer having at least some pendent substituents with the same charge as the charge of the active agent in an ionized form, and the carrier layer being compatible with and containing the active agent in a freely mobile form, means enabling transport of the active agent from the carrier layer to the ionomeric layer; and a counter electrode element in electrical contact with the current source and being adapted to be placed in ion-transmitting relation with the body surface. - View Dependent Claims (13, 17, 18)
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- 19. An active electrode element for an iontophoretic device suitable for administration of an active agent through a body surface of a host, comprising an ionomeric layer and an overlapping carrier layer, the carrier layer being compatible with and containing the active agent in a freely mobile form, means for maintaining the carrier layer separate from the ionomeric layer so as to prevent transport of the active agent into the ionomeric layer, means enabling the carrier layer to be placed into contact with the ionomeric layer to permit transport of the active agent into the ionomeric layer.
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32. A method for iontophoretically administering an active agent through a body surface of a host comprising:
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applying to the body surface active and counter electrode elements, the active electrode element comprising an ionomeric layer and an overlapping carrier layer, the ionomeric layer being arranged to be placed in ion-transmitting relation with the body surface and the carrier layer being compatible with and containing the active agent in a freely mobile form, being separated from the ionomeric layer so as to prevent transport of active agent into the ionomeric layer but being capable of being placed into contact with the ionomeric layer to permit transport of active agent into the ionomeric layer; contacting the ionomeric layer and the carrier layer; and generating an electric potential between the active and counter electrode elements and across the body surface such that the active agent is transported to the body surface. - View Dependent Claims (33, 34, 35, 36, 37, 38)
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39. A method for iontophoretically administering an active agent through a body surface of a host comprising:
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applying to the body surface a single layer active electrode element and a counter electrode element, the active electrode element being arranged to be placed in ion-transmitting relation with the body surface, the active electrode element comprising ionized active agent and an ionic organic polymer component having at least some pendent groups with the same charge as the ionized active agent; generating an electric potential between the active and counter electrode elements and across the body surface such that the active agent is transported to the body surface; and using the ionic organic polymer component to at least in part maintain the conductivity of the active electrode element during the transport of the active agent to the body surface. - View Dependent Claims (40, 41, 42, 43, 44)
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Specification