Laser corneal surgery

• US 5,423,801 A
• Filed: 12/19/1991
• Issued: 06/13/1995
• Est. Priority Date: 03/19/1986
• Status: Expired due to Fees

• Current Assignee: Summit Technologies LLC (Summit Global Group, LLC)
• Original Assignee: Summit Technologies LLC (Summit Global Group, LLC)
• Inventors: Marshall, John, Muller, David F.
• Primary Examiner(s): Shay, David M.
• Application Number:
  US07/810,323
• Time in Patent Office: 1,272 Days
• Field of Search: 606/2, 606/3, 606/5, 606/10-19
• US Class Current: 606/5
• CPC Class Codes: A61B 2017/306 holding by means of suction
• CPC Class Codes: A61F 2009/00872 Cornea
• CPC Class Codes: A61F 9/00804 Refractive treatments
• CPC Class Codes: A61F 9/00817 Beam shaping with masks
• CPC Class Codes: A61F 9/00819 with photoablatable masks
• CPC Class Codes: A61F 9/009 Auxiliary devices making contact with the eyeball and coupling in laser light, e.g. goniolenses apparatus for eye examination A61B3/0008
• CPC Class Codes: B23K 26/066 by using masks

Abstract

A method and system for reshaping Bowman'"'"'s membrane, which lies directly below the anterior epithelial surface of the cornea, to provide correction of refractive errors in the eye by photoablation of selective regions of the Bowman'"'"'s membrane without substantial penetration into the stroma of the eye is disclosed including a laser and a beam-shaping mask, disposed between the laser and the surface of the cornea, which imposes a defined ablation profile upon the Bowman'"'"'s membrane by laser radiation. The system can also include a feedback control for measuring the effectiveness of the laser during operation and for controlling the laser such that the reprofiling operation is substantially confined to the Bowman'"'"'s membrane throughout the procedure. The beam-shaping mask can include either an aperture e.g., a beam-shaping stop means alone or in combination with a beam-shaping window, or an mask which is erodible or otherwise graded in its absorptive capacity to present a predefined profile of resistance to the laser radiation.

Claims

1. A method of reprofiling a cornea to correct a refractive error in an eye, the method comprising

aligning a laser means for delivering a pulsed beam of laser radiation to the cornea, with an optical axis of a cornea, the cornea having an epithelial surface, an underlying stroma and a Bowman'"'"'s membrane disposed between the epithelial surface and the stroma;

selectively ablating and reshaping the cornea with an erodable means for masking said radiation, the masking means being disposed between the laser means and the surface, wherein the masking means has a selected composition and thickness, is erodable by radiation from the laser means and has a pre-defined profile of resistance to erosion by laser radiation such that upon irradiation a portion of the radiation is selectively absorbed by the masking means and another portion is transmitted to the surface of the cornea in accordance with the profile of the masking means to selectively erode the surface; and

controlling the laser radiation so that ablation terminates substantially within the Bowman'"'"'s membrane and not the underlying stroma.

2. The method of claim 1 wherein the method further includes varying the thickness of the masking means to provide the pre-defined profile of resistance.

3. The method of claim 1 wherein the method further comprises varying the composition of the masking means to provide the pre-defined profile of resistance.

4. The method of claim 1 further comprising the step of disposing a beam shaping means between the laser means and the cornea for varying a size of the beam of laser radiation incident upon the masking means and thereby selectively ablating and reshaping the cornea.

5. The method of claim 4 further includes the step of employing an optical system for receiving and transmitting at least a portion of the beam of laser radiation provided by the laser means, the optical system providing at least one region of divergence or convergence of the beam, and further including a beam-shaping stop means movable axially along the beam in the region of convergence or divergence, said stop means having at least one beam-shaping window and one beam-shaping stop portion, whereby the proportion of the total beam cross-section which passes through said window varies with the movement of the stop means axially along the beam in that region.

6. A method according to claim 4 in which the size of the area exposed to and eroded by the pulses of laser radiation is varied in a controlled manner by varying the beam size.

7. The method of claim 1 wherein the method of reprofiling further comprises

measuring a parameter which is a function of a shape of the cornea;

comparing such measurement with a desired value; and

deriving a feedback control signal from such comparison to provide further control for the laser means.

8. The method of claim 7 wherein the step of measuring a parameter comprises measuring a curvature of the corneal surface.

9. A system for reprofiling a corneal surface, the system comprising

laser means for delivering a pulsed beam of laser radiation to the cornea, said laser means being adapted for alignment with an optical axis of a cornea, the cornea having an epithelial surface, an underlying stroma and a Bowman'"'"'s membrane disposed between the epithelial surface and the stroma;

beam-shaping means disposable between the laser means and the cornea for selectively ablating and reshaping the cornea wherein the beam-shaping means further includes an erodable means for masking said radiation, the masking means being disposed between the laser means and the corneal surface, wherein the masking means has a selected composition and thickness, is erodable by radiation from the laser means and has a pre-defined profile of resistance to erosion by laser radiation such that upon irradiation a portion of the radiation is selectively absorbed by the masking means and another portion is transmitted to the surface of the cornea in accordance with the profile of the masking means to selectively erode the surface; and

control means for controlling the laser radiation so that ablation terminates substantially within the Bowman'"'"'s membrane and not the underlying stroma.

10. The system of claim 9 wherein the masking means further comprises a masking means of a selected thickness to provide the pre-defined profile of resistance.

11. The system of claim 9 wherein the masking means further comprises a masking means of a selected composition to provide the pre-defined profile of resistance.

12. The system of claim 9 wherein the system further comprises

measuring means for measuring a parameter which is a function of a shape of the cornea;

comparison means for comparing such measurement with a desired value; and

feedback means for deriving a feedback control signal from such comparison to provide further control for the laser means.

13. The system of claim 12 wherein the measuring means comprises means for measuring a curvature of the corneal surface.

14. The system of claim 9 wherein the beam shaping means further comprises am optical system for stopping a portion of the beam of laser radiation between the laser means and the cornea to vary the beam size and thereby provide selective ablation.

15. The system of claim 14 further includes means for providing at least one region of divergence or convergence of the beam of laser radiation, and further includes a beam-shaping stop means movable axially along the beam in the region of convergence or divergence, said stop means having at least one beam-shaping window and one beam-shaping stop portion, whereby the proportion of the total beam cross-section which passes through said window varies with the movement of the stop means axially along the beam in that region.

16. A system according to claim 14 in which the beam-shaping means further includes means for varying an area exposed to and eroded by the pulses of laser radiation in a controlled manner by varying a size of the beam.

17. A continuous procedure for laser reprofiling a cornea to correct a refractive error in the eye, said procedure comprising:

aligning a laser means for delivering a pulsed beam of laser radiation to the cornea in position relative to a cornea, the cornea having an epithelial surface, an underlying stroma and a Bowman'"'"'s membrane disposed between the epithelial surface and the stroma;

ablating an area of the cornea by delivering pulses of laser radiation to the cornea, such that portions of said epithelial surface and Bowman'"'"'s membrane are ablated concurrently by cumulative exposure to the laser radiation using an erodable mask disposed between said laser means and said epithelial layer, wherein said mask has a selected composition and thickness, is erodable by radiation from the laser means and has a predetermined profile of resistance to erosion by laser radiation such that upon irradiation, said mask erodes in a manner such as to achieve said ablation profile in said Bowman'"'"'s membrane;

varying the area of the cornea to which pulses are delivered to selectively ablate and reshape the cornea; and

controlling the laser radiation so that ablation terminates substantially within Bowman'"'"'s membrane and not the underlying stroma.

18. The continuous procedure of claim 17 wherein the step of ablating the cornea further comprises ablating the cornea without pretreatment of the cornea to remove epithelial tissue.

19. The continuous procedure of claim 17 wherein said profile of resistance of said mask is obtained by selecting a mask having a non-uniform thickness.

20. The continuous procedure of claim 17 wherein said profile of resistance of said mask is obtained by selecting a mask having a non-uniform composition.

21. The continuous procedure of claim 20 further comprising the step of feedback testing of said eye to determine if said ablation profile is achieved, said feedback testing having the substeps of:

measuring a parameter which is related to said ablation profile,

comparing the measurement of the parameter with a predetermined value,

determining the extent of achievement of said profile from said measurement comparison, and

providing a feedback signal to said laser means to control said pulses of laser radiation to achieve said profile.

22. The continuous procedure of claim 21 wherein substep of measuring said parameter further comprises measuring a curvature of said Bowman'"'"'s membrane.

23. The continuous procedure of claim 17 wherein said ablation profile in said Bowman'"'"'s membrane is achieved by the step of varying a shape of the beam of laser radiation incident on said epithelial layer and said Bowman'"'"'s membrane.

24. The continuous procedure of claim 23 wherein said step of varying the shape of the irradiating laser beam comprises having said beam traverse an optical system which reshapes said beam by providing at least one region of divergence or convergence of said beam, and further induces a beam shaping stop movable axially along said beam to shape said beam.

25. The continuous procedure of claim 23 wherein said change in shape of said beam comprises a change in beam area.