Stent capable of attachment within a body lumen

• US 5,423,885 A
• Filed: 07/14/1993
• Issued: 06/13/1995
• Est. Priority Date: 01/31/1992
• Status: Expired due to Term

• Current Assignee: Advanced Cardiovascular Systems Incorporated (Abbott Laboratories)
• Original Assignee: Advanced Cardiovascular Systems Incorporated (Abbott Laboratories)
• Inventors: Williams, Michael S.
• Primary Examiner(s): Green, Randall L.
• Assistant Examiner(s): BRITTINGHAM, DEBRA
• Application Number:
  US08/091,453
• Time in Patent Office: 699 Days
• Field of Search: 623/1, 623/11, 623/12, 606/191-200, 600/36, 29/23.1, 24/15, 24/270-276, 24/20 TT
• US Class Current: 623/1.17
• CPC Class Codes: A61B 2017/00004 (bio)absorbable, (bio)resorbable or resorptive
• CPC Class Codes: A61B 90/39 Markers, e.g. radio-opaque or breast lesions markers
• CPC Class Codes: A61F 2/07 Stent-grafts
• CPC Class Codes: A61F 2/92 Stents in the form of a rolled-up sheet expanding after insertion into the vessel , e.g. with a spiral shape in cross-section
• CPC Class Codes: A61F 2210/0004 bioabsorbable
• CPC Class Codes: A61F 2210/0019 operated at only one temperature whilst inside or touching the human body, e.g. constrained in a non-operative shape during surgery, another temperature only occurring before the operation
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61F 2250/0098 radio-opaque, e.g. radio-opaque markers
• CPC Class Codes: A61F 2310/00017 Iron- or Fe-based alloys, e.g. stainless steel
• CPC Class Codes: A61F 2310/00023 Titanium or titanium-based alloys, e.g. Ti-Ni alloys
• CPC Class Codes: A61F 2310/00131 Tantalum or Ta-based alloys
• CPC Class Codes: A61F 2310/00149 Platinum or Pt-based alloys
• CPC Class Codes: A61F 2310/00155 Gold or Au-based alloys
• CPC Class Codes: A61L 29/02 Inorganic materials
• CPC Class Codes: A61L 29/06 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence
• CPC Class Codes: Y10S 623/903 Blood vessel

Abstract

An expandable, balloon catheter delivered intravascular stent, especially adapted for cardiovascular applications, having a plurality of protrusions on its outer surface for engaging the artery walls in which it is disposed. The protrusions are formed from the body of the stent in a unitary, one-piece manner. Apertures are formed in the stent body from the space vacated in the body by the material forming the protrusions. When the stent is expanded by the balloon catheter, the protrusions engage both the apertures and the artery walls, to lock the stent into the expanded diameter. In this way axial displacement and radial collapse of the stent is avoided. The protrusions are arranged in a plurality of shapes, sizes and patterns. The stent may be made of a bioabsorbable material and/or a therapeutic drug delivery material.

Claims

1. An expandable intraluminal stent implanted in a vessel, comprising:

a body portion having a length and circumference formed from a substantially solid wall of biocompatible material;

a plurality of protrusions projecting along the length and circumference of said body portion;

a plurality of aperatures in said body portion, said aperatures being formed in said solid wall as a result of said plurality of protrusions being formed;

wherein some of said protrusions engage some of said apertures and several of said protrusions engage said vessel, to retain said intraluminal stent in said vessel.

2. The expandable intraluminal stent of claim 1, wherein:

said body portion has an exterior surface adjacent to said vessel, and said protrusions project from said exterior surface of said body portion.

3. The expandable intraluminal stent of claim 2, wherein said protrusions are unitary with said body portion and have a substantially "V" shape, and said apertures are in substantially the shape of said protrusions.

4. The expandable intraluminal stent of claim 3, wherein said protrusions have substantially equal sides that form an apex, with said sides spaced by an angle of about 90°

at said apex.

5. The expandable intraluminal stent of claim 4, wherein said protrusions are spaced at about 0.0189 inches to one another, and said sides are about 0.014 inches long.

6. The expandable intraluminal stent of claim 3, wherein said stent is formed of a bioabsorbable material.

7. The expandable intraluminal stent of claim 3, wherein said stent is radiopaque.

8. The expandable intraluminal stent of claim 3, wherein said stent is formed of a plastic, said plastic comprising a polymer selected from the group consisting of poly (lactic) acid, poly (glycolic) acid and polycaprolactone.

9. The expandable intraluminal stent of claim 8, wherein said polymer further comprises an associated copolymer selected from the group comprised of L-polylactic acid, DL-polylactic acid, and PGA-poly glycolic acid.

10. The expandable intraluminal stent of claim 3, wherein said protrusions are spaced from one another in a substantially uniform manner, to form rows of protrusions.

11. The expandable intraluminal stent of claim 3, wherein said protrusions are randomly dispersed throughout said body portion.

12. The expandable intraluminal stent of claim 3, wherein said stent is formed of a linear aliphatic polyester polymer.

13. The expandable intraluminal stent of claim 1, wherein said body portion is made of material formed into a cylinder.

14. The expandable intraluminal stent of claim 13, wherein said material contains a therapeutic drug.

15. The expandable intraluminal stent of claim 14, wherein said material comprises a polymer selected from the group consisting of polylactic acid, polyglycolic acid, polycaprolactone, and their associated copolymers, wherein said associated copolymers are selected from the group consisting of L-poly lactic acid, DL-poly lactic acid, and PGA-poly glycolic acid.

16. The expandable intraluminal stent of claim 13, wherein said body portion has an exterior surface adjacent to said vessel, and said protrusions project from said exterior surface of said body portion.

17. The expandable intraluminal stent of claim 13, wherein said material is bioabsorbable.

18. The expandable intraluminal stent of claim 13, wherein said cylinder has a longitudinal axis and two ends spaced along said longitudinal axis, and said ends are beveled to allow said stent to be more flexible at said ends.

21. The intraluminal stent of claim 18, wherein:

said protuberances are substantially "V"-shaped, and are unitary with said sheet.

19. An intraluminal stent implantable in a body lumen, comprising:

a sheet of material formed of a biocompatible material;

said sheet curled into a cylinder having overlapping ends;

said cylindrical sheet having a length and a circumference;

a plurality of protuberances projecting along the length and circumference of said sheet;

a plurality of apertures in said sheet of materials, said apertures corresponding in shape to the shape of said protuberances;

said apertures being formed in said sheet as a result of said plurality of protuberances being formed whereby said cylinder is expanded from a first diameter to a second, enlarged diameter so that said protuberances engage said body lumen.

20. The intraluminal stent of claim 19, wherein:

said cylinder has an outer portion, said outer portion being adjacent to said lumen, and said protuberances extend from said outer portion.

22. The intraluminal stent of claim 20, wherein said protuberances are dispersed around said outer portion of said cylinder in a random pattern.

23. The expandable intraluminal stent of claim 20, wherein said material is biocompatible and selected from the group consisting of poly (lactic acid), poly (glycolic acid), and polycaprolactone, polyorthoester, polyanhydride, polydioxanone, polyhydroxybutyrate, stainless steel, nickel-titanium, platinum, Nitinol™

, tantalum and gold.

24. The expandable intraluminal stent of claim 19, wherein said material contains a therapeutic drug.

25. The expandable intraluminal stent of claim 19 wherein said cylinder has a longitudinal axis and a two ends spaced along said longitudinal axis, and said ends are beveled to allow said stent to be more flexible at said ends.

26. The expandable intraluminal stent of claim 20, wherein said material is radiopaque.

27. An expandable intraluminal stent implantable in a body lumen, adapted to expand from a reduced diameter form to an expanded diameter form, comprising:

a sheet of biocompatible material curled into a cylinder having overlapping edges, an inner surface, and an exterior surface;

said apertures being formed in said sheet as a result of said plurality of protrusions being formed

said exterior surface contiguous with said lumen, and said overlapping edges allowing contact between said exterior surface and said interior surface;

said exterior surface having a surface texture made of a plurality of protrusions projecting along the length and circumference of said exterior surface;

a plurality of apertures in said sheet of material, said apertures corresponding in shape to the shape of said protrusions said apertures being formed in said sheet as a result of said plurality of protrusions being formed;

wherein said stent is held in said expanded diameter form to engage said lumen by combining said surface texture of said exterior surface engaging said inner surface and said surface texture of said exterior surface engaging said lumen.

28. The intraluminal stent of claim 27, wherein said inner surface contains a plurality of apertures, and said protrusions engage said apertures.

29. The intraluminal stent of claim 27, wherein said material is biodegradable.

30. The intraluminal stent of claim 29, wherein said material is a polymer selected from the group consisting of poly (lactic acid), poly (glycolic acid), polycaprolactone, polyorthoester, polyanhydride, polydioxanone and polyhydroxybutyrate.

31. The intraluminal stent of claim 27, wherein said material is a biocompatible material selected from the group consisting of stainless steel, nickel-titanium, platinum, Nitinol™

, tantalum and gold.

32. The intraluminal stent of claim 27, wherein said material contains a therapeutic agent.

33. The intraluminal stent of claim 27, wherein said cylinder has a longitudinal axis and a two ends spaced along said longitudinal axis, and said ends are beveled to allow said stent to be more flexible at said ends.

34. The intraluminal stent of claim 27, wherein said material is radiopaque.