Cyclically deformable haemocompatible and biocompatible devices coated with biocompatible carbonaceous material

• US 5,423,886 A
• Filed: 08/23/1993
• Issued: 06/13/1995
• Est. Priority Date: 05/11/1987
• Status: Expired due to Term

• Current Assignee: Sorin Biomedica Cardio Srl (LivaNova Plc)
• Original Assignee: Sorin Biomedica SpA (Snia SpA)
• Inventors: Santi, Marco, Vallana, Franco, Rinaldi, Stefano, Arru, Pietro
• Primary Examiner(s): PREBILIC, PAUL B
• Application Number:
  US08/110,419
• Time in Patent Office: 659 Days
• Field of Search: 623/1, 623/2, 623/3, 623/66, 623/901, 606/191, 604/266, 427/2
• US Class Current: 623/1.46
• CPC Class Codes: A61F 2/2412 with soft flexible valve members, e.g. tissue valves shaped like natural valves check valves with flexible valve members in general F16K15/14
• CPC Class Codes: A61M 60/148 in line with a blood vessel using resection or like techniques, e.g. permanent endovascular heart assist devices
• CPC Class Codes: A61M 60/178 drawing blood from a ventricle and returning the blood to the arterial system via a cannula external to the ventricle, e.g. left or right ventricular assist devices
• CPC Class Codes: A61M 60/427 the force acting on the blood contacting member being hydraulic or pneumatic
• CPC Class Codes: A61M 60/562 for making blood flow pulsatile in blood pumps that do not intrinsically create pulsatile flow
• CPC Class Codes: A61M 60/837 Aspects of flexible displacement members, e.g. shapes or materials
• CPC Class Codes: A61M 60/896 having flexible or resilient parts, e.g. flap valves

Abstract

There are disclosed devices for conditioning a blood flow which include at least one element with portions which are exposed to the blood and are deformable cyclically at a frequency comparable to the frequency of the heartbeat, in which the cyclically deformable portions have a continuous coating of biocompatible carbonaceous material comprised of carbon crystals having a density of greater than 2.1 grams per cubic centimeter applied by sputtering directly on and completely covering at least those portions of the device which are exposed to the blood.

Claims

1. A device for conditioning a blood flow including at least one element with portions which are exposed to the blood, are completely haemocompatible and biocompatible and are deformable cyclically at a frequency of from about 25 to about 200 cycles/minute, wherein said portions which are exposed to blood have a continuous coating of biocompatible carbonaceous material comprised of carbon crystals having a size of less than approximately 10^-8 meters and having a density of greater than 2.1 gm/cm³ applied by sputtering directly on and completely covering at least the portions which are exposed to the blood, wherein said portions which are exposed to blood are comprised of a polymeric material selected from the group consisting of polyurethanes, polytetrafluorethylenes, polyesters and silicone polymers.

2. A device according to claim 1, wherein said coating is constituted by carbonaceous material with an intrinsically turbostratic structure.

3. A device according to claim 1, wherein said coating has a thickness substantially between 0.1 and 1 micron.

4. A device according to claim 1, comprising a blood chamber with at least one wall portion which is deformable cyclically to pump the blood, wherein said coating of biocompatible carbonaceous material is provided at least on part of this deformable portion of wall.

5. A device according to claim 1, wherein said coating of biocompatible carbonaceous material is provided on substantially the whole of the device.

6. A device for conditioning a blood flow including at least one element with portions that are exposed to the blood, are completely haemocompatible and biocompatible and are deformable cyclically at a frequency of from about 25 to about 200 cycles/minute, wherein said portions which are exposed to blood have a continuous coating of biocompatible carbonaceous material comprised of carbon crystals having a size of less than approximately 10^-8 meters and having a density of greater than 2.1 gm/cm³ applied by sputtering directly on and completely covering the portions which are exposed to the blood, and wherein the sputtering is performed under high voltage, low current conditions.