Apparatus for handling liquid vials in an analytical device

• US 5,424,037 A
• Filed: 06/15/1994
• Issued: 06/13/1995
• Est. Priority Date: 08/04/1992
• Status: Expired due to Term

• Current Assignee: Agilent Technologies, Inc.
• Original Assignee: Hewlett-Packard Company (HP Inc.)
• Inventors: Zimmermann, Hans-Peter, Strohmeier, Fred, Witt, Klaus
• Primary Examiner(s): Warden, Robert J.
• Assistant Examiner(s): Carpenter, Robert
• Application Number:
  US08/261,026
• Time in Patent Office: 363 Days
• Field of Search: 422/63, 422/64, 422/70, 422/99, 422/100, 436/47, 436/48, 436/149, 436/150, 436/161, 436/806, 436/43, 204/299 R, 204/301
• US Class Current: 204/601
• CPC Class Codes: G01N 2035/00752 bar codes
• CPC Class Codes: G01N 2035/041 lifting items out of a rack for access
• CPC Class Codes: G01N 2035/0441 for samples
• CPC Class Codes: G01N 2035/0484 Belt or chain
• CPC Class Codes: G01N 27/44704 Details; Accessories
• CPC Class Codes: G01N 27/44743 Introducing samples
• CPC Class Codes: G01N 35/04 Details of the conveyor system G01N35/021 - G01N35/028 take precedence

Abstract

An apparatus for handling liquid vials in an analytical device comprises a single movable tray for accommodating a plurality of vials, and lifting devices arranged in the proximity of the tray for lifting vials out of the tray. The tray has a plurality of recesses for holding the vial. The recesses are open at the bottom so that a vertically movable finger of a lifting device which can be positioned underneath the bottom of a vial can move the vial out of the tray by an upward movement. When a vial has been lifted out of the tray, the tray remains freely rotatable so that a different vial can be positioned at a further lifting device and then lifted out of the tray. The invention provides a mechanically simple apparatus which is particularly suited for capillary electrophoresis for handling vials containing sample and electrolyte liquid. In capillary electrophoresis, two of the lifting devices are used for lifting vials to the ends of an electrophoresis capillary and a further lifting device is used for moving electrolyte vials to an arrangement for replenishing the electrolyte.

Claims

1. Apparatus for handling liquid vials in an analytical device, the apparatus comprising:

a capillary tube having first and second ends;

potential means for operating said apparatus to perform an electrophoretic separation;

a single movable tray for receiving liquid-containing vials, said tray comprising a plurality of vial holders for holding vials, a first lifting device arranged in proximity of the tray for lifting a first selected vial out of a vial holder and into engagement with said first end of said capillary tube, said first lifting device arranged to enable the tray to remain movable to bring a second vial into proximity of said second end of said capillary tube when the first vial has been lifted sufficiently far out of the vial holder to engage said first end of said capillary tube and a second lifting device for lifting said second vial into communication with said second end of said capillary tube so as to perform an electrophoretic separation of a sample under control of said potential means, and

drive means for moving the tray to position selected vials in juxtaposition to said first and second lifting devices.

2. An apparatus as in claim 1, wherein the first lifting device comprises a movable lifting element positioned underneath a bottom surface of said first selected vial and which is movable to lift said first selected vial out of the vial holder.

3. An apparatus as in claim 2, wherein the vial holder comprises a recess formed in a block of material, said recess shaped to substantially encompass an outer shape of the vial, and wherein an opening is provided in said block of material through which the lifting element is moved to lift the vial out of the holder.

4. An apparatus as in claim 1 wherein the tray is circular and is rotated around a center axis to position a selected vial at said at least one lifting device.

5. An apparatus as in claim 1, wherein the tray is elongated and is moved linearly to position a selectable vial at a lifting device.

10. An apparatus as in claim 1, further comprising:

a rocking lever in the head portion of the lifting device and an actuation belt fastened to the rocking lever and to the lifting element, whereby the actuation belt is tightened when the lifting element has moved downwards a predetermined distance such that the rocking lever is tilted, whereby the vial is stripped off the punching needle.

6. An apparatus for handling liquid vials, said apparatus comprising:

a tube with a first end and a second end;

a single tray for receiving liquid-containing vials, said tray comprising a plurality of vial holders for holding the vials,

at least first and second lifting devices arranged in proximity of the tray, said first lifting device for lifting a first vial out of a vial holder and into engagement with said first end of said tube, said first lifting device arranged to enable said single tray to remain movable when said first vial is moved out of said vial holder and into engagement with said first end, and said second lifting device for lifting a second vial out of a vial holder and into engagement with said second end of said tube, whereby fluid communication is enabled between said first vial and said second vial, and

drive means for moving the tray to position selected vials in juxtaposition to said first and second lifting devices.

7. An apparatus as in claim 6, wherein each lifting device comprises:

a lifting element which is vertically displaceable and which can be positioned underneath a bottom surface of the vial,

a head portion for receiving an upper part of a vial when the vial has been lifted by the lifting element, and

a punching needle arranged in the head portion for punching a hole in a septum of the vial when the vial is lifted towards the head portion by the lifting element.

8. An apparatus as in claim 7, wherein the head portion is vertically displaceable and wherein the head portion is moved upwards towards an end of a tube after the upper part of the vial has been received in the head portion.

9. An apparatus as in claim 8, wherein the punching needle is a hollow-needle having an inner diameter sufficient for guiding an end of the tube through it, the apparatus further comprising:

a funnel at the end of the punching needle opposite to an end of the tube, such that an end of the tube is captured by the head portion.

11. An apparatus as in claim 6, further, comprising:

a third lifting device and a replenishment needle which can be introduced into an electrolyte vial which has been lifted out of the tray by the third lifting device.

12. An apparatus as in claim 7, further comprising a third lifting device and a replenishment needle which can be introduced into an electrolyte vial which has been lifted out of the tray by the third lifting device.