Apparatus and method for analyzing and enhancing intercardiac signals

• US 5,425,373 A
• Filed: 01/14/1994
• Issued: 06/20/1995
• Est. Priority Date: 01/15/1991
• Status: Expired due to Term

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Inventors: Causey, James D. III
• Primary Examiner(s): Kamm, William E.
• Application Number:
  US08/181,330
• Time in Patent Office: 522 Days
• Field of Search: 128/697, 607/27, 607/30, 607/31
• US Class Current: 600/510
• CPC Class Codes: A61N 1/37252 Details of algorithms or data aspects of communication system, e.g. handshaking, transmitting specific data or segmenting data
• CPC Class Codes: Y10S 128/925 Neural network

Abstract

An external diagnostic/programming device is disclosed which includes means for both displaying intracardiac electrical signals sensed and telemetered from an implantable pacemaker in real-time, and for storing the intracardiac electrical signals for subsequent retrieval and analysis. The subsequent analysis selectively includes processing means for processing the signals off-line (i.e., not in real-time), using various signal processing strategies, such as digital filtering and frequency domain spectral analysis. The off-line signals may also be recursively processed in order to enhance the detection of a particular physiologic phenomena manifested by, but not readily discerned within, the unprocessed real-time signals.

Claims

1. A method for analyzing intracardiac electrical signals produced by an implanted pacemaker coupled to a mammalian heart to determine the presence or absence of a particular physiologic phenomena of the mammalian heart, said method comprising the steps of:

(a) receiving intracardiac electrical signals from an implanted pacemaker;

(b) converting said received intracardiac electrical signals to digital signals;

(c) storing said digital signals in a memory device;

(d) retrieving said digital signals from said memory device at a time subsequent to when the intracardiac electrical signals are first received, converted and stored;

(e) electronically enhancing said retrieved digital signals so as to reveal characteristics therein not readily discerned within the intracardiac signal when first received; and

(f) electronically displaying the revealed characteristics of the enhanced digital signals, which revealed characteristics provide an indication of the presence of particular physiologic phenomena associated with the mammalian heart to which the implanted pacemaker is coupled.

2. The method, as set forth in claim 1, wherein step (e) of electronically enhancing said retrieved digital signals comprises electronically enhancing a given sequence of retrieved digital signals in a series of recursive steps.

3. The method, as set forth in claim 1, wherein step (e) of electronically enhancing said retrieved digital signals comprises applying said retrieved digital signals to at least one of a group of signal processing strategies, said group of signal processing strategies comprising digital data averaging, digital high pass filtering, digital low pass filtering, digital notch filtering, digital convolution, and Fourier analysis.

4. The method, as set forth in claim 3, wherein step (e) of electronically enhancing said retrieved digital signals comprises applying said retrieved digital signals to a plurality of the signal processing strategies of said group of signal processing strategies.

5. The method, as set forth in claim 3, wherein step (e) of electronically enhancing said retrieved digital signals comprises applying said retrieved digital signals to a 60 Hz notch filter and a digital low pass filter to remove 60 Hz interference therefrom.

6. Apparatus for determining the presence or absence of a particular physiologic phenomena associated with a mammalian heart of a patient to which an implanted pacemaker is coupled, comprising:

means for receiving intracardiac electrical signal from the implanted pacemaker;

conversion means for converting said received intracardiac electrical signal to digital signals;

a memory device;

means for storing said digital signals in said memory device;

means for retrieving said digital signals from said memory device at a time subsequent to when the intracardiac electrical signals are first stored in said memory device;

enhancing means for electronically enhancing said retrieved digital signals; and

display means for displaying the electronically enhanced signals so as to reveal characteristics therein not readily discerned within the intracardiac signal when first received, which characteristics provide an indication of a particular physiologic phenomena associated with said mammalian heart.

7. The apparatus as set forth in claim 6, further including:

means for receiving surface electrocardiographic signals from the patient; and

multiplexer means for coupling a selected one of said received electrocardiographic or intracardiac electrical signal to said conversion means;

whereby either said received surface electrocardiographic signals or said received and amplified intracardiac electrical signal may be enhanced by said enhancing means.

8. The apparatus, as set forth in claim 7, wherein said multiplexer means couples said received electrocardiographic signals to said conversion means for a first sample time, and said received and amplified intracardiac electrical signal to said conversion means for a second sample time, whereby both said electrocardiographic and intracardiac electrical signal may be enhanced by said enhancing means.

9. The apparatus, as set forth in claim 6, further wherein said enhancing means comprises at least one of a digital high pass filter, a digital low pass filter, a digital notch filter, a digital convolution device, or a Fourier analysis device.

10. The apparatus, as set forth in claim 9, wherein said display means comprises:

means for converting said enhanced, retrieved digital signals to an analog signal; and

display means for displaying a graphical representation of said analog signal.

11. Apparatus for analyzing intracardiac electrical signals produced by an implantable pacemaker comprising:

transceiver means for transmitting control commands to and receiving transmitted intracardiac electrical signal from said implantable pacemaker, said control commands causing said implantable pacemaker to transmit intracardiac electrical signals, said transceiver means further comprising amplifier means for amplifying said intracardiac electrical signal received from said implanted pacemaker;

conversion means for converting said received and amplified intracardiac electrical signal to digital signals;

a data memory; and

control means for storing said digital signals in said data memory and retrieving said digital signals from said data memory at a time subsequent to when the intracardiac electrical signals are first stored in said memory device, said control means comprising processing means for electronically enhancing said retrieved digital signals so as to reveal characteristics therein not readily discerned within the intracardiac electrical signal when first received by said transceiver means.

12. The apparatus, as set forth in claim 11, further including:

means for receiving and amplifying surface electrocardiographic electrical signals; and

multiplexer means for coupling a selected one of said received electrocardiographic or intracardiac electrical signal to said conversion means;

whereby either said received surface electrocardiographic signals or said received intracardiac electrical signal may be converted by said conversion means and enhanced by said processing means.

13. The apparatus, as set forth in claim 11, wherein said processing means includes means for subjecting said retrieved digital signals to at least one of a digital high pass filter, a digital low pass filter, a digital notch filter, a digital convolution device, or a Fourier analysis device.

14. The apparatus, as set forth in claim 13, wherein said display means comprises:

means for converting said digital signals after being enhanced by said processing means to an analog signal; and

display means for displaying a graphical representation of said analog signal.

15. Apparatus for determining the presence or absence of a particular physiologic phenomena associated with a patient having an implanted pacemaker, said pacemaker having means for sensing and transmitting intracardiac electrical data signals, said apparatus comprising:

a telemetry transceiver that receives the intracardiac electrical data signals from the implanted pacemaker;

an analog-to-digital (A/D) converter connected to said telemetry transceiver that converts the received intracardiac electrical data signals to digital data signals;

a data memory that stores digital data signals;

a microprocessor coupled to said A/D converter and data memory;

a program memory coupled to said microprocessor, said program memory having a control program stored therein that controls said microprocessor so as to store said digital data signals in said data memory when first received from said A/D converter, and to retrieve said digital data signals from said data memory at a time subsequent to when the digital data signals are first stored in said data memory, said control program further controlling said microprocessor so as to electronically enhance the digital data signals retrieved from said data memory; and

a display device coupled to said microprocessor, said display device including means for displaying a graphical representation of the enhanced digital data signals to reveal characteristics therein not readily discerned within the intracardiac electrical data signals received by said telemetry receiver, which characteristics provide an indication of a particular physiologic phenomena associated with said patient.

16. The apparatus, as set forth in claim 15, further including:

a plurality of skin electrodes adapted for attachment to the skin of said patient;

a surface electrocardiographic amplifier attached to said skin electrodes that receives a surface electrocardiographic signal from the plurality of skin electrodes; and

a multiplexer circuit controlled by said microprocessor and connected to said surface electrocardiographic amplifier and said telemetry transceiver that includes means for coupling a selected one of said received surface electrocardiographic signal or said intracardiac electrical data signal to said A/D converter;

whereby either said received surface electrocardiographic signal or said received intracardiac electrical data signal may be stored in said data memory and subsequently electronically enhanced by said microprocessor.

17. The apparatus, as set forth in claim 16, wherein said multiplexer circuit couples said received surface electrocardiographic signal to said A/D converter for a first sample time, and said received intracardiac electrical signal to said A/D converter for a second sample time, whereby samples of both said surface electrocardiographic signal and intracardiac electrical signal may be stored in said data memory and subsequently retrieved for enhancement by said microprocessor.

18. The apparatus, as set forth in claim 17, further including a display device coupled to said microprocessor that displays a graphical representation of the electronically enhanced digital data signals.

19. The apparatus, as set forth in claim 16, wherein the microprocessor includes means for electronically enhancing the digital data signals retrieved from the data memory by subjecting said digital data signals to at least one of the signal processing strategies comprising:

digital data averaging, digital high pass filtering, digital low pass filtering, digital notch filtering, digital convolution or Fourier analysis.

20. A system for enhancing the detection of a particular physiologic phenomena manifest within an intracardiac electrical signal comprising:

an implantable pacemaker that includes means for sensing intracardiac electrical signal and means for telemetering such intracardiac electrical signal to a non-implanted location remote from the implantable pacemaker; and

an external programmer in signal contact with said implantable pacemaker, said external programmer including;

a telemetry receiver circuit that receives the intracardiac electrical signal telemetered from the implantable pacemaker

a data memory,

a storage system that stores the intracardiac electrical signal received by the telemetry receiver in said data memory,

a retrieval system that selectively retrieves the intracardiac electrical signal previously stored in the data memory, and

a processing system that processes the retrieved intracardiac electrical signal in accordance with at least one of a plurality of signal processing strategies, said signal processing strategies being selected to enhance the detection of a particular physiologic phenomena manifested within the intracardiac electrical signal;

display means for displaying the intracardiac signals after being processed by said processing system;

whereby said intracardiac electrical signal is processed at a time subsequent to their receipt within the external programmer, thereby enabling said signal processing strategies to be carried out offline (not in real-time), thereby facilitating the repetitive application of said signal processing strategies so as to better enhance the detection of the particular physiologic phenomena manifested within the intracardiac electrical signal.

21. The system, as set forth in claim 20, wherein said external programmer further includes:

surface electrocardiographic amplifiers for receiving surface electrographic signals; and

a multiplexer circuit for selectively connecting either said surface electrographic signals received by said surface electrocardiographic amplifiers or said intracardiac electrical signal received by said telemetry receiver to said storage system, whereby either said surface electrographic signals or said intracardiac electrical signal may be stored in said data memory.

22. The system, as set forth in claim 21, wherein said intracardiac electrical signal and said surface electrographic signals comprise analog signals, and wherein said external programmer further includes an analog-to-digital (A/D) converter that converts the surface electrographic signals and the intracardiac electrical signal to digital signals prior to having said signals stored in said data memory.

23. The system, as set forth in claim 22, wherein said A/D converter includes means for converting the analog intracardiac electrical signal and surface electrographic signals to digital signals at a prescribed sampling rate.

24. The system, as set forth in claim 21, wherein said storage system, retrieval system, and processing system comprise:

a data bus connected to said data memory and A/D converter;

a processing unit connected to the data bus;

a read-only memory (ROM) connected to the data bus, said ROM having a program loaded therein that controls the operation of said processing unit so as to;

(a) selectively store the digital signals output from the A/D converter in said data memory, (b) selectively retrieve the digital signals stored in the data memory at a time subsequent to when they are first stored therein, and (c) process the retrieved digital signals offline in accordance with one of said signal processing strategies.

25. The system, as set forth in claim 24, wherein said external programmer further includes:

a digital-to-analog (D/A) converter coupled to said data bus that converts digital data appearing on said data bus to an analog signal appearing on an output port of said D/A converter; and

a display connected to the output port of said D/A converter that provides a graphical display of the analog signal appearing on the output port of the D/A converter;

the program loaded in said ROM further controlling said processing unit so as to selectively place the retrieved digital signals processed by the processing unit on the data bus for conversion to analog signals by said D/A converter, with said analog signals being graphically displayed by said display, the display of said analog signals providing an alternate technique for detecting the particular physiologic phenomena manifested within the intracardiac electrical signal.

26. The system, as set forth in claim 20, wherein said at least one signal processing strategy used by said processing system is selected from the group comprising digital averaging, digital high pass filtering, digital low pass filtering, digital notch filtering, digital convolution or Fourier analysis.

27. A method for analyzing intracardiac electrical signals comprising the steps of:

(a) sensing intracardiac electrical signals with an implanted pacemaker, said implanted pacemaker having pacing/sensing leads in contact with a patient'"'"'s heart;

(b) telemetering said intracardiac electrical signals to a non-implanted receiver;

(c) receiving and amplifying the intracardiac electrical signals at the non-implanted receiver;

(d) electronically holding a selected sample of the received and amplified intracardiac electrical signals for subsequent off-line processing;

(e) electronically processing the held sample of the intracardiac electrical signals pursuant to a selected processing strategy, the processed intracardiac electrical signal sample providing an indication of characteristics in the intracardiac electrical signal not readily discernable using real-time processing.

28. The method, as set forth in claim 27, wherein said received and amplified intracardiac electrical signals comprise analog signals, and wherein step (d) comprises converting said received and amplified intracardiac electrical signals to digital signals on a sampled basis, and storing said digital signals as digital sampled signals in a data memory.

29. The method, as set forth in claim 28, wherein step (e) includes retrieving said digital sampled signals from said data memory and subjecting said retrieved digital sampled signals to a first signal processing strategy to produce a first result, subjecting said first result to a second signal processing strategy to produce a second result, and so on, with the result of a preceding signal processing strategy being used as starting data for a next signal processing strategy, until a prescribed number of different signal processing strategies have been used.

30. The method, as set forth in claim 29, wherein the prescribed number of different signal processing strategies used in step (e) includes a plurality of signal averaging, low pass filtering, high pass filtering, notch filtering, convolution and Fourier analysis.

31. The method, as set forth in claim 27, wherein step (e) includes retrieving said digital sampled signals from said data memory, subjecting said retrieved digital sampled signals to said selected processing strategy to produce output data, reapplying said output data to said selected processing strategy to produce new output data, and continuing to reapply said new output data to said selected processing strategy for a prescribed number of iterations.

32. The method, as set forth in claim 31, wherein the prescribed number of iterations comprises at least two.

33. The method, as set forth in claim 31, wherein the electronic processing carried out in step (e) includes processing the held sample of the intracardiac electrical signals in accordance with at least one of:

signal averaging, low pass filtering, high pass filtering, notch filtering, convolution or Fourier analysis.

34. The method, as set forth in claim 27, further including:

sensing surface electrocardiographic signals from a patient;

receiving and amplifying the sensed surface electrographic signals at the non-implanted receiver; and

electronically holding a selected sample of either the received and amplified intracardiac electrical signals or surface electrographic signals for subsequent off-line processing.

35. The method, as set forth in claim 34, wherein the step of electronically holding includes electronically holding said received and amplified intracardiac electrical signals and said surface electrocardiographic signals on an alternating basis, to allow subsequent off-line processing of two channels of data.