Method and apparatus for inducing the permeation of medication into internal tissue
First Claim
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1. A method for inducing the permeation of a fluid having charged molecules into a blood vessel comprising the steps of:
- providing electrodes external of the patient'"'"'s body;
inserting percutaneously into a blood vessel a balloon catheter having an elongate flexible shaft, with a porous balloon at the distal end of said shaft, an internal electrode positioned inside said balloon on said shaft, and a lumen extending through said shaft and terminating in an outlet distally beyond said balloon, said lumen being adapted to receive blood proximally of said balloon and to enable blood to flow through said catheter and be emitted distally of said balloon to permit distal perfusion during inflation of said balloon;
inflating said balloon with said liquid; and
developing an electric field flowing from said internal electrode to said external electrode so that said liquid flows radially outward through said pores in said balloon to the blood vessel to be treated.
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Abstract
A method and apparatus for selectively treating a targeted portion of internal body tissue of a patient by providing an internal electrode at a point adjacent the tissue to be treated and electrodes external to the patient'"'"'s body. Fluid containing Ionic molecules is supplied to a location between the internal electrode and the external electrodes and an electric field radiating outwardly from the internal electrode to the external electrodes is created so that said fluid flows outwardly away from said internal electrode into the tissue to be treated.
163 Citations
7 Claims
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1. A method for inducing the permeation of a fluid having charged molecules into a blood vessel comprising the steps of:
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providing electrodes external of the patient'"'"'s body; inserting percutaneously into a blood vessel a balloon catheter having an elongate flexible shaft, with a porous balloon at the distal end of said shaft, an internal electrode positioned inside said balloon on said shaft, and a lumen extending through said shaft and terminating in an outlet distally beyond said balloon, said lumen being adapted to receive blood proximally of said balloon and to enable blood to flow through said catheter and be emitted distally of said balloon to permit distal perfusion during inflation of said balloon; inflating said balloon with said liquid; and developing an electric field flowing from said internal electrode to said external electrode so that said liquid flows radially outward through said pores in said balloon to the blood vessel to be treated. - View Dependent Claims (2, 3, 4)
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5. A catheter for selectively inducing the permeation of liquid to a targeted portion of a blood vessel in the body of a patient comprising:
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an elongate flexible shaft dimensioned for insertion into the human vascular system, the shaft having proximal and distal ends; a balloon for emitting the liquid from the catheter; a first lumen extending along said shaft for delivering the liquid from the proximal end of the catheter to the distal region of the catheter; a second lumen extending through said shaft and terminating in an outlet distally beyond said balloon, said second lumen being adapted to receive blood proximally of said balloon and to enable blood to flow through the catheter and be emitted distally of said balloon to permit distal perfusion during inflation of said balloon; an internal electrode carried by the catheter at the distal end of the catheter; and a conductor extending through said shaft and being electrically connected to said internal electrode, the proximal end of the conductor being connectible to a source of electrical energy.
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6. An apparatus for selectively inducing the permeation of liquid to a targeted portion of a blood vessel in the body of a patient comprising:
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at least one external electrode adapted to be positioned outside of the patient'"'"'s body; a catheter having an elongate flexible shaft dimensioned for insertion into the vascular system, the catheter having proximal and distal ends, a balloon for emitting said liquid from said catheter; a first lumen extending along said catheter shaft for delivering said liquid from the proximal to the distal region of the catheter, a second lumen extending through said catheter shaft and terminating in an outlet distally beyond said balloon, said second lumen being adapted to receive blood proximally of said balloon and to enable blood to flow through said catheter and be emitted distally of said balloon to permit distal perfusion of blood during inflation of said balloon; an internal electrode carried by said catheter at the distal end of said catheter; a conductor extending through said catheter shaft and being electrically connected to said internal electrode, the proximal end of said conductor being connectible to a source of electrical energy and, an electrical energy source for inducing an electric field between said internal electrode and said external electrode so that fluid emitted from the distal end of said catheter will flow in a direction extending from the internally placed electrode outwardly toward the external electrode.
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7. A method of delivering a drug to a treatment site in a vessel which contains a flowing first fluid, the method comprising the steps of:
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providing at least one electrode external of the patient'"'"'s body; inserting percutaneously into the vessel a catheter having an elongate flexible shaft, with an inflatable balloon at the distal end of said shaft, an internal electrode positioned in the area of said balloon, and a lumen extending through said shaft and terminating in an outlet distally beyond said balloon; inflating said balloon at the treatment site; delivering a drug in the area of the balloon; perfusing the first fluid through an opening near the proximal end of said balloon to an opening located distally of said balloon; and developing an electric field flowing from said internal electrode so that said drug flows radially outward to the vessel to be treated.
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Specification