Sensor for non-invasive, in vivo determination of an analyte and blood flow

• US 5,425,868 A
• Filed: 07/23/1993
• Issued: 06/20/1995
• Est. Priority Date: 07/24/1992
• Status: Expired due to Term

• Current Assignee: Radiometer Medical ApS (Danaher Corporation)
• Original Assignee: Radiometer A/S (Danaher Corporation)
• Inventors: Pedersen, Knud G.
• Primary Examiner(s): Tung, T.
• Application Number:
  US08/097,377
• Time in Patent Office: 697 Days
• Field of Search: 204/153.17, 204/415, 204/408, 128/639-644, 128/637, 128/635
• US Class Current: 204/408
• CPC Class Codes: A61B 5/14542 for measuring blood gases A61B5/14551 takes precedence
• CPC Class Codes: A61B 5/1477 non-invasive
• CPC Class Codes: A61B 5/1491 Heated applicators

Abstract

The sensor (1) comprises a sensor body (3) thermostatable by means of a first thermostating system (14,15) and having an outer surface (3a,40a) for application to the human body (28) in heat conductive relationship therewith, said outer surface (3a,40a) forming the measuring surface of the sensor (1). The sensor (1) further comprises analyte sensing means (7,8) arranged in said sensor body (3) and being thermostated through said body (3) by means of the first thermostating system (14,15). The sensor (1) further comprises means (16,41) arranged in the sensor body (3) in heat insulated relationship therewith while in heat conductive relationship with a delimited surface part of the sensor measuring surface (3a,40a). The means (16,41) is thermostatable by means of a second thermostating system. The delimited surface part is located within the outer periphery of the sensor measuring surface (3a,40a).

Claims

1. A sensor for non-invasive in-vivo determination of both an analyte concentration and blood flow, the sensor comprising:

I. a sensor body comprising;

a) analyte sensing means comprising an analyte sensor surface for application to a human body in heat-conductive relation therewith for determination of the analyte concentration, the analyte sensor surface having an outer periphery; and

b) a first thermostating system for establishing and maintaining the sensor body and analyte sensor surface at a first temperature;

II. blood flow sensing means comprising a blood flow sensor surface located adjacent to the analyte sensor surface and adapted for heat-conductive application to the human body simultaneously with the analyte sensor surface, the blood flow sensor located within the outer periphery of the analyte sensor surface; and

III. a second thermostating system located within the sensor body in heat-insulated relation therewith and in heat conductive relation with the blood flow sensor surface, the second thermostating system adapted to heat the blood flow sensor surface to a second temperature different from the first temperature for a period of time sufficient to enable determination of the blood flow at the second temperature while not significantly changing the temperature of the analtye sensor surface from the first temperature.

2. The sensor according to claim 1 wherein the analyte sensing means comprises blood gas measuring means.

3. The sensor according to claim 1 wherein:

the sensor body comprises a recess extending through the analyte sensor surface to the interior of the sensor body;

the blood flow sensing surface is located in the recess immediately adjacent to the analyte sensor surface; and

the second thermostating system is located within the recess in the interior of the sensor body immediately adjacent to the blood flow sensor surface.

4. The sensor according to claim 3 wherein the blood flow sensor surface is covered with a layer of a heat-conductive material.

5. The sensor according to claim 3 wherein one or both of the first and second thermostating systems comprises a self-thermostating element.

6. The sensor according to claim 5 wherein the self-thermostating means comprises a thermistor or resistance wire.

7. The sensor according to claim 1 wherein one or both of the first and second thermostating systems comprises a self-thermostating element.

8. The sensor according to claim 1 wherein the blood flow sensing means comprises the second thermostating system.

9. The sensor according to claim 8 wherein the blood flow sensing means comprises a self-thermostating element.