Polymeric buffering composition for fiber-optic physiological probe and method of making the same

• US 5,426,213 A
• Filed: 09/09/1994
• Issued: 06/20/1995
• Est. Priority Date: 12/23/1991
• Status: Expired due to Fees

• Current Assignee: Abbott Laboratories Incorporated
• Original Assignee: Abbott Laboratories Incorporated
• Inventors: Lyon, Kenneth S., Brotherton, Vince, Iyer, Lokanathan M.
• Primary Examiner(s): Killos, Paul J.
• Application Number:
  US08/303,610
• Time in Patent Office: 284 Days
• Field of Search: 560/222, 423/420
• US Class Current: 560/222
• CPC Class Codes: C07C 219/08 having at least one of the hydroxy groups esterified by a carboxylic acid having the esterifying carboxyl group bound to an acyclic carbon atom of an acyclic unsaturated carbon skeleton
• CPC Class Codes: C07C 233/38 having the carbon atom of the carboxamide group bound to a carbon atom of an acyclic unsaturated carbon skeleton
• CPC Class Codes: C08F 20/34 Esters containing nitrogen , e.g. N,N-dimethylaminoethyl (meth)acrylate
• CPC Class Codes: C08F 20/60 containing nitrogen in addition to the carbonamido nitrogen

Abstract

High molecular weight buffering compositions and polymeric buffering compositions incorporating such compositions are described. The compositions are useful in applications where lower molecular weight buffers are unsatisfactory because of their tendency to leak out of an encapsulating membrane. Methods of making such compositions are described, as well as a particular application in a fiber optic carbon dioxide physiological probe.

Claims

1. A method for making methacrylamidopropyltrimethylammonium bicarbonate comprising the step of:

passing methacrylamidopropyltrimethylammonium chloride over an ion exchange media that includes bicarbonate ions that are exchangeable with chloride ions of the methacrylamidopropyltrimethylammonium chloride.

2. The method of claim 1, wherein the ion exchange media is a cross-linked matrix of styrene and divinylbenzene in a bicarbonate form.

3. The method of claim 1, further comprising the step of polymerizing the methacrylamidopropyltrimethylammonium bicarbonate with a nonionic, hydrophobic acrylate.

4. The method of claim 3, wherein the nonionic, hydrophobic acrylate is represented by the formula ##STR8## wherein R₅ is hydrogen or methyl radical and R₆ is methyl, ethyl, or butyl radical.

5. The method of claim 4, wherein the nonionic, hydrophobic acrylate is methyl methacrylate.

6. The method of claim 4, wherein the methacrylamidopropyltrimethylammonium bicarbonate and non-ionic hydrophobic acrylate form a mixture that comprises about 20 to 40 weight percent of the methacrylamidopropyltrimethylammonium bicarbonate and about 80 to 60 weight percent non-ionic hydrophobic acrylate.