Dialysis membrane composed of polysaccharide ether II

• US 5,427,684 A
• Filed: 06/07/1993
• Issued: 06/27/1995
• Est. Priority Date: 06/05/1992
• Status: Expired due to Fees

• Current Assignee: Membrana GmbH (Asahi Kasei Corporation)
• Original Assignee: AKZO NV (Nouryon BV)
• Inventors: Rintelen, Thomas, Diamantoglou, Michael, Dunweg, Gustav
• Primary Examiner(s): Dawson, Robert A.
• Assistant Examiner(s): Fortuna, Ana M.
• Application Number:
  US08/073,359
• Time in Patent Office: 750 Days
• Field of Search: 210/500.27, 210/500.29, 210/500.28, 210/500.23, 210/500.31, 210/500.32, 210/500.3, 210/500.38, 536/20, 264/41, 264/199, 264/212, 264/563, 525/54.1, 435/243
• US Class Current: 210/500.23
• CPC Class Codes: B01D 71/22 Cellulose ethers
• CPC Class Codes: C08B 11/16 Aryl or aralkyl ethers

Abstract

A dialysis membrane for hemodialysis in the form of sheet films, tubular films, or hollow fibers is composed of a polysaccharide ether. The polysaccharide ether has a structure given by the formula ##STR1## in which cell is the skeleton of the unmodified cellulose molecule or of the chitin molecule, each with no hydroxyl groups, s is equal to 3 for the unmodified cellulose molecule and 2 for the chitin molecule, and x is the degree of etherification, which is in the range from 0.001 to 0.079, and R is an optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, arylalkyl, arylalkenyl, and/or arylalkynyl group with 3 to 25 carbon atoms, and/or the radical of a heterocyclic compound with 3 to 25 carbon atoms, in which the carbon chain may be interrupted by oxygen or sulfur atoms.

Claims

1. A dialysis membrane for hemodialysis comprising a sheet film, tubular film, or hollow fiber composed of polysaccharide ether, the polysaccharide ether having a structure given by the formula ##STR7## in which cell is the skeleton of an unmodified cellulose molecule or of a chitin molecule, each with no hydroxyl groups, s is equal to 3 when the cell is the skeleton of an unmodified cellulose molecule and 2 when the cell is the skeleton of a chitin molecule, x is the degree of etherification in the range of from 0.001 to 0.079, and R is at least one substituted or unsubstituted group selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, arylalkyl, arylalkenyl, arylalkynyl group with 3 to 25 carbon atoms, and a radical of a heterocyclic compound with 3 to 25 carbon atoms, in which the carbon chain may be interrupted by oxygen or sulfur atoms.

2. A dialysis membrane according to claim 1, wherein said radical is substituted with a nonionic group.

3. A dialysis membrane according to claim 2, wherein the nonionic group is selected from the group consisting of OR'"'"', SR'"'"', halogen, and R'"'"', in which R'"'"' is hydrogen, methyl, ethyl, or R.

4. A dialysis membrane according to claim 1, wherein R is a benzyl, methylbenzyl, methoxybenzyl, chlorobenzyl, hexyl, dodecyl, or octadecyl group.

5. A dialysis membrane according to claim 1, wherein R is selected from the group consisting of a hydroxypropyl, hydroxybutyl, hydroxydodecyl, 2-hydroxypropyl butyl ether, 2-hydroxypropyl dodecyl ether, 2-hydroxypropyl cyclohexyl ether, 2-hydroxypropyl benzyl ether, and 2-hydroxypropyl phenyl ether group.

6. A dialysis membrane according to claim 1, wherein x is from 0.071 to 0.079.

7. A dialysis membrane according to claim 1, wherein the membrane is produced from an aqueous spinning solution that contains the polysaccharide ether.

8. A dialysis membrane according to claim 7, wherein the aqueous spinning solution is a cuprammonium solution.

9. A dialysis membrane according to claim 7, wherein the membrane is produced from an aqueous tertiary amine N-oxide spinning solution that contains the polysaccharide ether.

10. A dialysis membrane according to claim 9, wherein the aqueous N-oxide spinning solution is a solution of N-methylmorpholine N-oxide.

11. A dialysis membrane according to claim 7, wherein the membrane is produced from an organic amide solvent containing lithium chloride that contains the polysaccharide ether.

12. A dialysis membrane according to claim 11, wherein the solvent containing lithium chloride is lithium chloride/dimethylacetamide or lithium chloride/N-methylpyrrolidone.

13. A dialysis membrane according to claim 7, wherein the spinning solution contains 2 to 25 wt. % polysaccharide ether.

14. A dialysis membrane according to claim 13, wherein the spinning solution contains 5 to 15 wt. % polysaccharide ether.

15. A dialysis membrane according to claim 7, wherein the spinning solution has a viscosity of from 10 to 300 Pa.s.

16. A dialysis membrane for hemodialysis comprising a sheet film, tubular film, or hollow fiber composed of polysaccharide ether, the polysaccharide ether having a structure given by the formula ##STR8## in which cell is the skeleton of an unmodified cellulose molecule or of a chitin molecule, each with no hydroxyl groups, s is equal to 3 when the cell is the skeleton of an unmodified cellulose molecule and 2 when the cell is the skeleton of a chitin molecule, x is the degree of etherification in the range of from 0.001 to 0.019, and R is at least one substituted or unsubstituted group selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, arylalkyl, arylalkenyl, arylalkynyl group with 3 to 25 carbon atoms, and a radical of a heterocyclic compound with 3 to 25 carbon atoms, in which the carbon chain may be interrupted by oxygen or sulfur atoms.

17. A dialysis membrane according to claim 16, wherein said radical is substituted with a nonionic group.

18. A dialysis membrane according to claim 17, wherein the nonionic group is selected from the group consisting of OR'"'"', SR'"'"', halogen, and R'"'"', in which R'"'"' is hydrogen, methyl, ethyl, or R.

19. A dialysis membrane according to claim 16, wherein R is a benzyl, methylbenzyl, methoxybenzyl, chlorobenzyl, hexyl, dodecyl, or octadecyl group.

20. A dialysis membrane according to claim 16, wherein R is selected from the group consisting of a hydroxypropyl, hydroxybutyl, hydroxydodecyl, 2-hydroxypropyl butyl ether, 2-hydroxypropyl dodecyl ether, 2-hydroxypropyl cyclohexyl ether, 2-hydroxypropyl benzyl ether, and 2-hydroxypropyl phenyl ether group.

21. A dialysis membrane according to claim 16, wherein the polysaccharide ether has a degree of polymerization (DP) of from 200 to 5000.

22. A dialysis membrane for hemodialysis comprising a sheet film, tubular film, or hollow fiber composed of polysaccharide ether having a degree of polymerization (DP) of from 200 to 5000, the polysaccharide ether having a structure given by the formula ##STR9## in which cell is the skeleton of an unmodified cellulose molecule or of a chitin molecule, each with no hydroxyl groups, s is equal to 3 when the cell is the skeleton of an unmodified cellulose molecule and 2 when the cell is the skeleton of a chitin molecule, x is the degree of etherification in the range of from 0.001 to 0.079, and R is at least one substituted or unsubstituted group selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, arylalkyl, arylalkenyl, arylalkynyl group with 3 to 25 carbon atoms, and a radical of a heterocyclic compound with 3 to 25 carbon atoms, in which the carbon chain may be interrupted by oxygen or sulfur atoms.

23. A dialysis membrane according to claim 22, wherein said radical is substituted with a nonionic group.

24. A dialysis membrane according to claim 23, wherein the nonionic group is selected from the group consisting of OR'"'"', SR'"'"', halogen, and R'"'"', in which R'"'"' is hydrogen, methyl, ethyl, or R.

25. A dialysis membrane according to claim 22, wherein R is a benzyl, methylbenzyl, methoxybenzyl, chlorobenzyl, hexyl, dodecyl, or octadecyl group.

26. A dialysis membrane according to claim 22, wherein R is selected from the group consisting of a hydroxypropyl, hydroxybutyl, hydroxydodecyl, 2-hydroxypropyl butyl ether, 2-hydroxypropyl dodecyl ether, 2-hydroxypropyl cyclohexyl ether, 2-hydroxypropyl benzyl ether, and 2-hydroxypropyl phenyl ether group.

27. A dialysis membrane according to claim 22, wherein x is from 0.001 to 0.019.

28. A dialysis membrane according to claim 22, wherein x is from 0.071 to 0.079.