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Multi-optical detection system

  • US 5,427,915 A
  • Filed: 08/09/1993
  • Issued: 06/27/1995
  • Est. Priority Date: 06/15/1989
  • Status: Expired due to Fees
First Claim
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1. The method for determining the presence of an analyte in a sample, employing a detection system comprising a crystalline anisotropic polymerized polyunsaturated lipid monolayer having extended conjugated aliphatic unsaturation and groups attached to one surface of said layer said surface being hydrophilic, wherein said groups are one member of a specific binding pair and said analyte is a member of said same specific binding pair, wherein specific binding of said analyte or a conjugate of a label and said analyte to said groups on said hydrophilic surface of said lipid monolayer produces a change in intensity, orientation and/or amplitude of light emanating from said lipid monolayer said method comprising:

  • contacting said lipid monolayer with said sample;

    irradiating said lipid monolayer with collimated light; and

    determining the change in intensity, orientation and/or amplitude of light emanating from said lipid monolayer as compared to an change in intensity, orientation and/or amplitude of light emanating from said lipid monolayer produced by contacting said lipid monolayer with a control sample as a determination of the presence of said analyte in said sample.

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