Method for palladium catalyzed carbon-carbon coulping and products
First Claim
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1. A method for the preparation of pyrimidine nucleosides modified at the 5-position of the pyrimidine ring from a pyrimidine starting material containing a halogen leaving group attached to the 5-position of the pyrimidine ring, such method comprising the steps of:
- preparing a solution of a palladium catalyst of the formula PdL3, wherein L is triphenyl phosphine (PPhd3);
reacting said pyrimidine starting material with a tetraalkyl tin compound of the formula R'"'"'SnR3 ", wherein R" is selected from the group consisting of an alkyl of C1-C4 carbon and R'"'"' is selected from the group consisting of a carbonyl of C1-C7 C1-C7 carbons, a carbalkoxy of C1-C5 carbons, an alkenyl of C1-C3 carbons, an alkoxy of C1-C4 carbons or phenyl (C6 H5), with the palladium catalyst; and
isolating and purifying said modified pyrimidine nucleoside.
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Abstract
This invention discloses an improved method for the preparation of a superior palladim catalyst that is capable of coupling vinyl and aryl stannanes to 2'"'"'-deoxy-5-iodouridine.
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Citations
9 Claims
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1. A method for the preparation of pyrimidine nucleosides modified at the 5-position of the pyrimidine ring from a pyrimidine starting material containing a halogen leaving group attached to the 5-position of the pyrimidine ring, such method comprising the steps of:
- preparing a solution of a palladium catalyst of the formula PdL3, wherein L is triphenyl phosphine (PPhd3);
reacting said pyrimidine starting material with a tetraalkyl tin compound of the formula R'"'"'SnR3 ", wherein R" is selected from the group consisting of an alkyl of C1-C4 carbon and R'"'"' is selected from the group consisting of a carbonyl of C1-C7 C1-C7 carbons, a carbalkoxy of C1-C5 carbons, an alkenyl of C1-C3 carbons, an alkoxy of C1-C4 carbons or phenyl (C6 H5), with the palladium catalyst; and isolating and purifying said modified pyrimidine nucleoside. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
- preparing a solution of a palladium catalyst of the formula PdL3, wherein L is triphenyl phosphine (PPhd3);
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