Process for making 5-introbarbituric acid and salts thereof
First Claim
1. A process for preparing salts of 5-nitrobarbituric acid comprising allowing an in situ generated diethyl nitro malonate to condense with urea to obtain 5-nitrobarbituric acid and neutralizing said acid with a nitrogen containing organic base, ammonium, hydrazinium, alkali metal salts, alkaline earth metal salts, salts of transition metals, or mixtures thereof, and recovering the thus formed salt of 5-nitrobarbituric acid without distillation or isolation of intermediate products during the preparation of the 5-nitrobarbituric acid salts.
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Abstract
A process for preparing salts of 5-nitrobarbituric acid involves allowing an in situ generated a compound represented by formula (I): ##STR1## wherein R1 and R2 are the same or different and are, H, C1 to C8 alkyl or substituted C1 to C8 alkyl, aryl or substituted aryl, to condense with urea to obtain a condensation product; and neutralizing the condensation product with at least one organic base and another cation source (MX) at a pH≧7 and recovering the thus formed salt of 5-nitrobarbituric acid.
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Citations
18 Claims
- 1. A process for preparing salts of 5-nitrobarbituric acid comprising allowing an in situ generated diethyl nitro malonate to condense with urea to obtain 5-nitrobarbituric acid and neutralizing said acid with a nitrogen containing organic base, ammonium, hydrazinium, alkali metal salts, alkaline earth metal salts, salts of transition metals, or mixtures thereof, and recovering the thus formed salt of 5-nitrobarbituric acid without distillation or isolation of intermediate products during the preparation of the 5-nitrobarbituric acid salts.
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13. A process for preparing salts of 5-nitrobarbituric acid comprising allowing an in situ generated a compound represented by formula (I):
- ##STR5## wherein Rl and R2 are the same or different and are, H, C1 to C8 alkyl or substituted C1 to C8 alkyl, aryl or substituted aryl, to condense with urea to obtain a condensation product; and
neutralizing the condensation product with at least one member selected from the group consisting of an organic base and another cation source (MX), and recovering the thus formed salt of 5-nitrobarbituric acid without distillation or isolation of intermediate products during the preparation of the 5-nitrobarbituric acid salts.
- ##STR5## wherein Rl and R2 are the same or different and are, H, C1 to C8 alkyl or substituted C1 to C8 alkyl, aryl or substituted aryl, to condense with urea to obtain a condensation product; and
- 14. A process for preparing a salt of 5-nitrobarbituric acid comprising adding a dehydrating reagent to nitromalonic acid and urea, and neutralizing the reaction product thereof to obtain a salt of 5-nitrobarbituric acid without distillation or isolation of intermediate products during the preparation of the 5-nitrobarbituric acid salts.
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18. A process for preparing 5-nitrobarbituric acid comprising generating in situ diethyl nitromalonate and condensing the diethyl nitromalonate with urea and recovering the thus formed 5-nitrobarbituric acid.
Specification