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Non-fibrogenic high mannuronate alginate coated transplants, processes for their manufacture, and methods for their use

  • US 5,429,821 A
  • Filed: 05/29/1992
  • Issued: 07/04/1995
  • Est. Priority Date: 05/29/1992
  • Status: Expired due to Term
First Claim
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1. A viable, physiologically active and acceptable tissue transplant suitable for long-term transplantation,wherein said transplant is protected from destruction by the host immune system by coating said transplant essentially with a purified non-fibrogenic and non-toxic alkaline earth metal alginate selected from the group consisting of calcium alginate, magnesium alginate and a mixture thereof;

  • wherein said alkaline earth metal alginate is substantially free from fucose, sulfate, phlorogluoinol or protein moieties;

    wherein said alkaline earth metal alginate provides a barrier having a thickness between about 20 μ

    m and about 200 μ

    m providing a prolonged protection of said transplant from destruction of said transplant by the host immune system;

    wherein said barrier is permeable enough to allow diffusion and release of proteins having an intermediate size from the transplant into the host body.

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