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Oligonucleotides having selectably cleavable and/or abasic sites

  • US 5,430,136 A
  • Filed: 07/27/1990
  • Issued: 07/04/1995
  • Est. Priority Date: 10/16/1984
  • Status: Expired due to Fees
First Claim
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1. A polynucleotide having the structure ##STR23## wherein DNA1 is a first segment of DNA;

  • DNA2 is a second segment of DNA; and

    R is selected from the group consisting of 2-nitrobenzyl, 4-penten-1-yl, ##STR24## in which R'"'"' is hydrogen, aryl or aralkyl;

    the Ri are indepenedently selected from the group consisting of amino, nitro, halogeno, hydroxyl, lower alkyl and lower alkoxy;

    the Rj are independently selected from the group consisting of amino, nitro, halogeno, hydroxyl, lower alkyl and lower alkoxy;

    i is zero, 1, 2 or 3; and

    j is zero, 1, 2, 3 or 4.

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