Iontophoresis electronic device having a ramped output current

• US 5,431,625 A
• Filed: 12/01/1992
• Issued: 07/11/1995
• Est. Priority Date: 02/01/1991
• Status: Expired due to Term

• Current Assignee: Donald D. Maurer, Encore Medical Asset Corporation (Enovis Corp.), Encore Medical LP (Enovis Corp.)
• Original Assignee: EMPI Incorporated (Enovis Corp.)
• Inventors: Williams, Thomas J., Fabian, Liboslav
• Primary Examiner(s): Cohen, Lee S.
• Assistant Examiner(s): Jastrzab, Jeffrey R.
• Application Number:
  US07/984,303
• Time in Patent Office: 952 Days
• Field of Search: 604/20, 604/290, 607/63, 607/153, 607/64, 607/72, 607/74, 607/75
• US Class Current: 604/20
• CPC Class Codes: A61N 1/30 Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis

Abstract

An iontophoresis controller is configured for connection to an iontophoresis electrode pair. The controller controls infusion of a selected dose of ionic drugs into a patient through the electrode pair during a treatment period. The controller includes an electrode driver channel having an electrode output configured for electrical connection to the electrode pair. The electrode driver channel delivers a substantially constant electrode output current at a selected treatment level through the electrode output during the treatment period. The electrode output current rises exponentially from approximately zero to the selected treatment level, remains at the selected treatment level during the treatment period, and then falls exponentially to approximately zero. A microprocessor controls operation of the electrode driver channel to generate the electrode output current during the treatment period.

Claims

1. An iontophoresis controller which adjusts current to an iontophoresis electrode pair to control infusion of a selected dose of ionic drugs into a patient through the electrode pair during a treatment period, the controller comprising:

an electrode driver channel generating an electrode output current which has an intensity that rises exponentially from approximately zero to a selected treatment current intensity, remains at the selected treatment current intensity, and then falls exponentially to approximately zero, the electrode driver channel having an electrode output adapted to be connected to the electrode pair to deliver the electrode output current to the electrode pair; and

means for controlling the electrode driver channel to generate the electrode output current during the treatment period, thereby controlling infusion of the selected dose of ionic drugs into the patient through the electrode pair during the treatment period.

2. The iontophoresis controller of claim 1 wherein:

the means for controlling the electrode driver channel comprises a microprocessor which selectively applies a ramp voltage to a ramp enable output; and

the electrode driver channel further comprises;

an RC circuit having a resistance and a capacitance connected in series with the ramp enable output such that the RC circuit generates an RC output voltage that rises exponentially from approximately zero to the ramp voltage when the microprocessor applies the ramp voltage to the ramp enable output and falls exponentially from the ramp voltage to approximately zero when the microprocessor removes the ramp voltage from the ramp enable output; and

means connected to the RC circuit for delivering the electrode output current through the electrode output as a function of the RC output voltage.

3. The iontophoresis controller of claim 2 wherein the RC circuit has a time constant which is selectable in magnitude between a first time constant and a second time constant and wherein the second time constant is larger than the first time constant.

4. The iontophoresis controller of claim 3 wherein:

the microprocessor further comprises a ramp bypass output which selectively applies the ramp voltage to one of the ramp bypass output and the ramp enable output; and

the RC circuit resistance comprises a first resistor which is connected between the ramp bypass output and the capacitance, and a second resistor connected between the ramp enable output and the capacitance, wherein the first resistor has a first resistance such that the RC output voltage rises and falls exponentially with the first time constant when the ramp voltage is applied to the ramp bypass output and wherein the second resistor has a second resistance, larger than the first resistance, such that the RC output voltage rises and falls exponentially with the second time constant when the ramp voltage is applied to the ramp enable output.

5. The iontophoresis controller of claim 2 wherein the means for delivering the electrode output current as a function of the RC output voltage comprises:

an amplifier connected to the RC circuit in a voltage follower configuration which receives the RC output voltage and generates an amplifier output which follows the RC output voltage;

an adjustable voltage divider which has an input connected to the amplifier output and which has an adjustable voltage divider output, wherein the adjustable voltage divider generates a treatment control voltage on the adjustable voltage divider output which has a magnitude that is a function of the RC output voltage and an adjustment of the adjustable voltage divider; and

means for controlling the electrode output current as a function of the treatment control voltage.

6. The iontophoresis controller of claim 5 wherein the microprocessor further comprises:

a control enable output connected to the means for controlling the electrode output current such that the microprocessor selectively applies a control signal on the control enable output which enables and disables the means for controlling the electrode output; and

a reference current input connected to the adjustable voltage divider output such that the microprocessor monitors the treatment control voltage generated on the voltage divider output when the means for controlling the electrode output current is disabled and determines the electrode output current to be delivered through the electrode output based on the monitored treatment control voltage.

7. The iontophoresis controller of claim 5 wherein:

the electrode driver channel further comprises;

a feedback circuit having a feedback input connected to the electrode output and having a feedback output such that the feedback circuit generates a feedback voltage on the feedback output as a function of the electrode output current delivered through the electrode output; and

the microprocessor further comprises;

a control enable output connected to the means for controlling the electrode output current such that the microprocessor selectively a control signal on the control enable output which enables and disables the means for controlling the electrode output current; and

a delivered current input connected to the feedback output such that the microprocessor monitors the feedback voltage generated on the feedback output when the means for controlling the electrode output current is enabled and such that the microprocessor determines the electrode output current delivered through the electrode output based on monitored the feedback voltage.

8. The iontophoresis controller of claim 2 wherein the means for delivering the electrode output current as a function of the RC output voltage comprises:

means for generating a modulation treatment control voltage as a function of the RC output voltage;

a pulse width modulator having a modulation control input, a modulation feedback input and a modulated output such that the modulation control input is connected to the means for generating the modulation treatment control voltage and such that the pulse width modulator generates a modulated signal on the modulated output having a pulse width that is a function of the modulation treatment control voltage and a modulation feedback voltage which is applied to the modulation feedback input;

an isolation transformer having a primary coil and a secondary coil, with the primary coil connected to the modulated output and the secondary coil connected to the electrode output for generating such that the isolation transformer generates the electrode output current in response to the modulated signal received at the primary coil;

a rectifier connected to the secondary coil, which rectifies the electrode output current; and

a modulation feedback circuit having an input connected to the electrode output and having an output connected to the modulation feedback input of the pulse width modulator such that the modulation feedback circuit generates the modulation feedback voltage on the modulation feedback circuit output as a function of the electrode output current.

9. The iontophoresis controller of claim 1 wherein the electrode driver channel further comprises:

means for generating a modulation treatment control voltage which rises exponentially from approximately zero to a selected modulation treatment control level, remains at the modulation treatment control level during the treatment period, and then fails exponentially to approximately zero;

a pulse width modulator having a modulation control input, a modulation feedback input and a modulated output such that the modulation control input is connected to the means for generating a modulation treatment control voltage and such that the pulse width modulator generates a modulated signal on the modulated output having a pulse width which is a function of the modulation treatment control voltage and a modulation feedback voltage which is applied to the modulation feedback input;

an isolation transformer having a primary coil and a secondary coil, with the primary coil connected to the modulated output and the secondary coil connected to the electrode output for generating the electrode output current in response to the modulated signal received at the primary coil;

a rectifier connected to the secondary coil, which rectifies the electrode output current; and

a modulation feedback circuit having an input connected to the electrode output and having an output connected to the modulation feedback input of the pulse width modulator such that the modulation feedback circuit generates the modulation feedback voltage on the modulation feedback circuit output as a function of the electrode output current.

10. An iontophoresis controller which adjusts current to an iontophoresis electrode pair to control infusion of a selected dose of ionic drugs into a patient through the electrode pair during a treatment period, the controller comprising:

a microprocessor having a ramp enable output such that the microprocessor selectively applies a ramp voltage on the ramp enable output;

an RC circuit having an input connected to the ramp enable output and having an RC output, wherein the RC circuit has a time constant which is selectable in magnitude between a first time constant and a second time constant and wherein the second time constant is larger than the first time constant such that the RC circuit generates an RC output voltage on the RC output as a function of the ramp voltage and the selected time constant;

an electrode output adapted to be electrically connected to the electrode pair; and

means connected between the RC circuit and the electrode output for generating an electrode output current through the electrode output which has an intensity that rises exponentially from approximately zero to a selected treatment current intensity, remains at the selected treatment current intensity, and then falls exponentially to approximately zero as a function of the RC output voltage, thereby controlling infusion of the selected dose of ionic drugs into the patient through the electrode pair during the treatment period.

11. An iontophoresis controller which adjust current to an iontophoresis electrode pair to control infusion of a selected dose of ionic drugs into a patient through the electrode pair during a treatment period, the controller comprising:

a microprocessor having a ramp enable output such that the microprocessor selectively applies a ramp voltage on the ramp enable output;

an RC circuit having an RC input connected to the ramp enable output and having an RC output such that the RC circuit generates an RC output voltage on the RC output that rises exponentially from approximately zero to the ramp voltage when the microprocessor applies the ramp voltage to the ramp enable output and falls exponentially from the ramp voltage to approximately zero when the microprocessor removes the ramp voltage from the ramp enable output;

an amplifier connected to the RC output in a voltage follower configuration such that the amplifier receives the RC output voltage and generates an amplifier output signal which follows the RC output voltage;

an adjustable voltage divider having an input connected to the amplifier which receives the amplifier output signal and having a voltage divider output, such that the adjustable voltage divider generates a treatment control voltage on the voltage divider output which has a magnitude that is a function of the amplifier output signal and an adjustment of the adjustable voltage divider;

an electrode output adapted to be electrically connected to the electrode pair; and

means connected to the adjustable voltage divider and to the electrode output for generating an electrode output current through the electrode output as a function of the magnitude of the treatment control voltage, thereby controlling infusion of the selected dose of ionic drugs into the patient through the electrode pair during the treatment period.

12. An iontophoresis controller which adjust current to an iontophoresis electrode pair to control infusion of a selected dose of ionic drugs into a patient through the electrode pair during a treatment period, the controller comprising:

an electrode output adapted to be electrically connected to the electrode pair;

means for generating a modulation treatment control voltage which rises exponentially from approximately zero to a selected modulation treatment control level, remains at the modulation treatment control level, and then falls exponentially to approximately zero;

pulse width modulator means having a modulation control input, a modulation feedback input and a modulated output, wherein the modulation control input is connected to the means for generating a modulation treatment control voltage for generating a modulated signal on the modulated output having a pulse width which is a function of the modulation treatment control voltage and a modulation feedback voltage which is applied to the modulation feedback input;

isolation transformer means having a primary coil and a secondary coil, with the primary coil connected to the modulated output and the secondary coil connected to the electrode output for generating an electrode output current in response to the modulated signal received at the primary coil;

a rectifier connected to the secondary coil, which rectifies the electrode output current; and

modulation feedback means having an input connected to the electrode output and having an output connected to the modulation feedback input of the pulse width modulator means for generating the modulation feedback voltage on the modulation feedback means output as a function of the electrode output current.