Absorbable block copolymers and surgical articles fabricated therefrom

• US 5,431,679 A
• Filed: 03/10/1994
• Issued: 07/11/1995
• Est. Priority Date: 03/10/1994
• Status: Expired due to Term

• Current Assignee: United States Surgical Corporation (Medtronic Plc)
• Original Assignee: United States Surgical Corporation (Medtronic Plc)
• Inventors: Liu, Cheng-Kung, Bennett, Steven L.
• Primary Examiner(s): BUTTNER, DAVID J
• Application Number:
  US08/209,330
• Time in Patent Office: 488 Days
• Field of Search: 525/411, 525/413, 525/415, 606/230, 606/77, 606/157, 606/219
• US Class Current: 606/230
• CPC Class Codes: A61B 17/08 Wound clamps or clips, i.e. not or only partly penetrating the tissue suture bridges A61B17/0466; Devices for bringing together the edges of a wound
• CPC Class Codes: A61B 17/58 for osteosynthesis, e.g. bone plates, screws , setting implements or the like A61B17/14, A61B17/16 take precedence
• CPC Class Codes: A61L 17/12 Homopolymers or copolymers of glycolic acid or lactic acid
• CPC Class Codes: A61L 31/06 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: C08G 63/08 Lactones or lactides
• CPC Class Codes: C08G 63/64 Polyesters containing both carboxylic ester groups and carbonate groups
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence

Abstract

Block copolymers wherein one of the blocks is made from hard phase forming monomers and another of the blocks is made from soft phase forming monomers copolymerized with randomly intermingled units of other soft phase forming monomers. The copolymers are useful in forming surgical articles, including both monofilament and multifilament sutures.

Claims

1. A block copolymer comprising:

a) from about 50 to about 65 percent by weight of copolymer blocks comprising a predominant amount of glycolic acid ester units; and

b) the remainder of said blocks comprising random copolymers of caprolactone and 1,3 dioxane-2-one, said blocks comprising random copolymers of epsilon-caprolactone and 1,3 dioxane-2-one being formed from the random polymerization of about 35 percent by weight of caprolactone and about 65 percent by weight 1,3 dioxane-2-one.

2. The block copolymer of claim 1, wherein said block copolymer is a tri-block copolymer.

3. The tri-block copolymer of claim 2, comprising:

a) about 50 to about 65 percent of said copolymer by weight end blocks, said end blocks comprising a predominant amount of glycolic acid ester units, and

b) a center block comprising random copolymers of epsilon-caprolactone and 1,3 dioxane-2-one.

4. A surgical article formed totally or in part from the block copolymer of claim 1.

5. The surgical article of claim 4, wherein said surgical article is selected from the group consisting of clips, staples, sutures, pins, screws, prosthetic devices, anastomosis rings, and growth matrices.

6. The surgical article of claim 5, wherein said suture is a monofilament suture.

7. The surgical article of claim 4 further comprising a medico-surgically useful substance.

8. A block copolymer comprising:

a) from about 40 to about 70 percent by weight of said copolymer blocks comprising a predominant amount of glycolic acid ester units; and

b) the remainder of said blocks comprising random copolymers of caprolactone and 1,3 dioxane-2-one, said blocks comprising random copolymers of epsilon-caprolactone and 1,3 dioxane-2-one formed from the random polymerization of caprolactone and 1,3 dioxane-2-one.

9. The block copolymer of claim 8, wherein said block copolymer is a tri-block copolymer.

10. A surgical article formed totally or in part from the block copolymer of claim 8.

11. The surgical article of claim 10, wherein said surgical article is selected from the group consisting of clips, staples, sutures, pins, screws, prosthetic devices, anastomosis rings, and growth matrices.