Method of verifying capture of the heart by a pacemaker

• US 5,431,693 A
• Filed: 12/10/1993
• Issued: 07/11/1995
• Est. Priority Date: 12/10/1993
• Status: Expired due to Term

• Current Assignee: Intermedics Incorporated
• Original Assignee: Intermedics Incorporated
• Inventors: Schroeppel, Edward A.
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): Getzow, Scott M.
• Application Number:
  US08/165,251
• Time in Patent Office: 578 Days
• Field of Search: 607/26, 607/27, 607/28
• US Class Current: 607/28
• CPC Class Codes: A61B 5/349 Detecting specific parameters of the electrocardiograph cycle
• CPC Class Codes: A61B 5/7203 for noise prevention, reduction or removal
• CPC Class Codes: A61B 5/7239 using differentiation including higher order derivatives
• CPC Class Codes: A61N 1/36507 controlled by gradient or slope of the heart potential
• CPC Class Codes: A61N 1/371 Capture, i.e. successful stimulation

Abstract

A method of verifying cardiac capture. A cardiac signal evoked in response to a cardiac stimulation pulse is sensed via an electrode. The sensed signal is lowpass filtered to remove noise and to pass frequencies characteristic of the evoked cardiac signal. The filtered signal is processed to render a waveform signal representing the second derivative of said filtered signal and the second derivative signal is further analyzed to detect a minimum and a maximum amplitude excursion during a selected window of time beginning at a selected time delay following delivery of the cardiac stimulation pulse. The amplitude difference between the minimum and the maximum is measured and compared to a first reference value. The amplitude of the second derivative is measured during a second selected window of time beginning at a selected time delay following delivery of said cardiac stimulation pulse, and compared to a second reference value. A capture detect signal is generated if the amplitude difference exceeds the first reference value, but the amplitude does not exceed the second reference value.

Claims

1. A method of detecting cardiac non-capture by sensing via an electrode a cardiac signal after delivery of a cardiac stimulation pulse, comprising the steps of:

sensing a waveform signal at said electrode following delivery of said cardiac stimulation pulse;

filtering said sensed waveform signal to pass frequencies characteristic of an evoked cardiac capture signal;

processing said filtered waveform signal to render a second derivative waveform signal representing the second derivative of said filtered signal;

processing and analyzing said second derivative waveform signal to detect a minimum and a maximum amplitude excursion during a selected window of time beginning at a selected time delay following delivery of said cardiac stimulation pulse; and

measuring the amplitude difference between said minimum and said maximum, and comparing said amplitude difference to a reference value and generating a non-capture detect signal if said amplitude difference does not exceed said reference value.

2. The method of claim 1, in which said selected window of time comprises a first selected window of time, and further including the steps of:

measuring the amplitude of said second derivative waveform signal during a second selected window of time beginning at a selected time delay following delivery of said cardiac stimulation pulse;

comparing said amplitude to a second reference value, and generating an intrinsic contraction detect signal if said amplitude exceeds said second reference value during said second selected window of time; and

not generating said non-capture detect signal if said amplitude exceeds said second reference value during said second selected window of time.

3. The method of claim 2, in which said second window of time ends at a time later than said first window of time.

4. A method of detecting cardiac capture by sensing via an electrode a cardiac signal after delivery of a cardiac stimulation pulse, comprising the steps of:

sensing a waveform signal at said electrode following delivery of said cardiac stimulation pulse;

filtering said sensed waveform signal to pass frequencies characteristic of an evoked cardiac capture signal;

processing said filtered waveform signal to render a second derivative waveform signal representing the second derivative of said filtered signal;

processing and analyzing said second derivative waveform signal to detect a minimum and a maximum amplitude excursion during a selected window of time beginning at a selected time delay following delivery of said cardiac stimulation pulse; and

measuring the amplitude difference between said minimum and said maximum, and comparing said amplitude difference to a reference value and generating a capture detect signal if said amplitude difference exceeds said reference value.

5. The method of claim 4, in which said selected window of time comprises a first selected window of time and said reference value comprises a first reference value, and further including the steps of:

measuring the amplitude of said second derivative waveform signal during a second selected window of time beginning at a selected time delay following delivery of said cardiac stimulation pulse;

comparing said amplitude to a second reference value, and generating an intrinsic contraction detect signal if said amplitude exceeds said second reference value during said second selected window of time; and

not generating said capture detect signal if said amplitude exceeds said second reference value during said second selected window of time.

6. The method of claim 5, in which said second window of time ends at a time later than said first window of time.

7. A method of discriminating between a cardiac capture and an intrinsic contraction by sensing via an electrode a cardiac signal after delivery of a cardiac stimulation pulse, comprising the steps of:

sensing a waveform signal at said electrode following delivery of said cardiac stimulation pulse;

filtering said sensed waveform signal to pass frequencies characteristic of an evoked cardiac capture signal;

processing said filtered waveform signal to render a waveform signal representing the second derivative of said filtered signal;

processing and analyzing said second derivative waveform signal to detect a minimum and a maximum amplitude excursion during a first selected window of time beginning at a selected time delay following delivery of said cardiac stimulation pulse;

measuring the amplitude difference between said minimum and said maximum, and comparing said amplitude difference to a first reference value;

measuring the amplitude of said second derivative waveform signal during a second selected window of time beginning at a selected time delay following delivery of said cardiac stimulation pulse; and

comparing said amplitude difference to a first reference value, and comparing said amplitude to a second reference value, and generating a capture detect signal if said amplitude difference exceeds said first reference value, but said amplitude does not exceed said second reference value.

8. The method of claim 7, in which said second reference value is greater than said first reference value.

9. The method of claim 8, in which said second window of time ends at a time later than said first window of time.

10. A method of detecting an intrinsic contraction by sensing via an electrode a cardiac signal after delivery of a cardiac stimulation pulse, comprising the steps of:

sensing a waveform signal at said electrode after delivery of said cardiac stimulation pulse;

processing said sensed waveform signal to render a second derivative waveform signal representing the second derivative of said sense waveform signal;

measuring the amplitude of said second derivative waveform signal during a selected window of time beginning at a selected time delay following delivery of said cardiac stimulation pulse; and

comparing said amplitude to a reference value, and generating an intrinsic contraction detect signal if said amplitude exceeds said reference value during said selected window of time.