Dispensing device containing a hydrophobic medium

• US 5,431,921 A
• Filed: 03/12/1993
• Issued: 07/11/1995
• Est. Priority Date: 09/28/1990
• Status: Expired due to Fees

• Current Assignee: Pfizer Inc.
• Original Assignee: Pfizer Inc.
• Inventors: Thombre, Avinash G.
• Primary Examiner(s): Webman, Edward J.
• Application Number:
  US07/987,282
• Time in Patent Office: 851 Days
• Field of Search: 424/486, 424/424, 424/425, 424/426, 424/494, 424/495, 424/497, 424/461, 424/462, 424/473, 424/480, 424/482, 424/438
• US Class Current: 424/424
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas

Abstract

A device for the controlled delivery of an insoluble or partially aqueous insoluble beneficial agent to an aqueous containing environment. The device comprises a shaped wall that surrounds and defines an internal reservoir. The wall is formed at least in part of a sintered polymer microporous membrane permeable to a beneficial agent-containing hydrophobic medium when the wall is present in the aqueous containing environment. The reservoir contains a mixture of a hydrophilic swellable composition and a beneficial agent-containing hydrophobic medium.

Claims

1. A device for controlled delivery of a beneficial agent to an aqueous containing environment, said device comprising:

a shaped wall having a thickness of at least 100μ

m that surrounds and defines an internal reservoir;

said wall at least in part permeable to the aqueous environment and said wall formed at least in part of a sintered polymer microporous membrane permeable to a beneficial agent-containing hydrophobic medium when the wall is present in the aqueous containing environment, said sintered polymer impregnated with a low vapor pressure hydrophobic medium; and

said reservoir containing a mixture of a hydrophilic swellable composition and said beneficial agent-containing hydrophobic medium, said beneficial agent being insoluble or partially insoluble in said aqueous containing environment.

2. The device as recited in claim 1 wherein said beneficial agent has a solubility more than about one part solute to 1000 part aqueous solvent and less than about one part solute to 30 parts aqueous solvent.

3. The device as recited in claim 2 herein said beneficial agent is soluble in said hydrophobic medium.

4. The device as recited in claim 3 wherein said swellable composition comprises hydrogel and said reservoir contains sufficient hydrogel such that the swelled hydrogel fills at least about 50% of the reservoir.

5. A device for controlled delivery of a beneficial agent to an aqueous containing environment, said device comprising:

a shaped wall having a thickness of at least 100μ

m that surrounds and defines an internal reservoir;

said wall at least in part permeable to the aqueous environment and said wall formed at least in part of a sintered polymer microporous membrane permeable to a beneficial agent-containing hydrophobic medium when the wall is present in the aqueous containing environment, said sintered polymer impregnated with hydrogel and wetted with a low vapor pressure hydrophobic medium; and

said reservoir containing a mixture of a hydrophilic swellable composition and said beneficial agent-containing hydrophobic medium, said beneficial agent being insoluble or partially insoluble in said aqueous containing environment.

6. A device for controlled delivery of a beneficial agent to an aqueous containing environment, said device comprising:

a shaped wall having a thickness of at least 100μ

m that surrounds and defines an internal reservoir;

said wall at least in part permeable to the aqueous environment and said wall formed at least in part of a sintered polymer microporous membrane, said sintered polymer impregnated with a hydrophilic hydrogel wetted with a hydrophilic medium and at least one hole provided therethrough; and

said reservoir containing a mixture of a hydrophilic swellable composition and said beneficial agent-containing hydrophobic medium, said beneficial agent being insoluble or partially insoluble in said aqueous containing environment.

7. A device for controlled delivery of a beneficial agent to an aqueous containing environment, said device comprising:

a shaped wall having a thickness of at least 100μ

m that surrounds and defines an internal reservoir;

said wall at least in part permeable to the aqueous environment and said wall formed at least in part of a material permeable to a beneficial agent-containing hydrophobic medium when the wall is present in the aqueous containing environment and said wall formed at least in part of a sintered polymer microporous membrane permeable to the aqueous containing environment, said sintered polymer impregnated with a low vapor pressure hydrophilic medium; and

said reservoir containing a mixture of a hydrophilic swellable composition and said beneficial agent-containing hydrophobic medium, said beneficial agent being insoluble or partially insoluble in said aqueous containing environment.

8. A device for controlled delivery of a beneficial agent to an aqueous containing environment, said device comprising:

a shaped wall having a thickness of at least 100μ

m that surrounds and defines an internal reservoir;

said wall at least in part permeable to the aqueous environment and said wall formed at least in part of a material permeable to a beneficial agent-containing hydrophobic medium when the wall is present in the aqueous containing environment and said wall formed at least in part of a sintered polymer microporous membrane permeable to the aqueous containing environment, said sintered polymer impregnated with a hydrogel and wetted with a low vapor pressure hydrophilic medium; and

said reservoir containing a mixture of a hydrophilic swellable composition and said beneficial agent-containing hydrophobic medium, said beneficial agent being insoluble or partially insoluble in said aqueous containing environment.

9. A device for controlled delivery of a beneficial agent to an aqueous containing environment, said device comprising:

a shaped wall having a thickness of at least 100 μ

m that surrounds and defines an internal reservoir;

said wall at least in part permeable to the aqueous environment and said wall formed at least in part of a material permeable to a beneficial agent-containing hydrophobic medium when the wall is present in the aqueous containing environment; and

said reservoir containing sufficient air to achieve a predetermined time lag release and a mixture of a hydrophilic swellable composition and said beneficial agent-containing hydrophobic medium, said beneficial agent being insoluble or partially insoluble in said aqueous containing environment.