Polymer particles and method for preparing by polymerization of encapsulated monomers

• US 5,432,210 A
• Filed: 11/22/1993
• Issued: 07/11/1995
• Est. Priority Date: 11/22/1993
• Status: Expired due to Fees

• Current Assignee: Rohm and Haas Company (Dow, Inc.)
• Original Assignee: Rohm and Haas Company (Dow, Inc.)
• Inventors: Bogan, Leonard E. Jr.
• Primary Examiner(s): Szekely, Peter A.
• Application Number:
  US08/156,346
• Time in Patent Office: 596 Days
• Field of Search: 523/201, 524/457, 524/458, 524/459, 524/460, 524/461, 524/539, 525/54.1, 525/291, 525/902
• US Class Current: 523/201
• CPC Class Codes: C08F 289/00 Macromolecular compounds obtained by polymerising monomers on to macromolecular compounds not provided for in groups C08F251/00 - C08F287/00
• CPC Class Codes: Y10S 525/902 Core-shell

Abstract

A method for preparing polymer particles having diameters within the range from less than 0.1 micron to about 200 microns is described. The method involves encapsulating at least one water insoluble monomer within a water soluble polymer containing at least one thiol functional group. This is accomplished by combining an organic phase containing the monomers and a free radical source with an aqueous phase containing the polymer to form a two phase mixture, and subjecting the two phase mixture to agitation or ultrasonic irradiation. This invention allows for the preparation of polymer particles with sizes not available by conventional suspension or emulsion polymerization methods. It also provides for polymer particles within the specifed size range having compositions not readily obtained by other polymerization methods. The polymer particles made by this method have an exterior portion of water soluble polymer bound to an interior polymer. The exterior polymer, when it is a condensation polymer such as for example a protein, may be removed by acid hydrolysis.

Claims

1. A polymer particle consisting essentially of an exterior water soluble polymer comprising one or more thiol functional group, and an interior polymer, wherein the interior polymer is formed from at least one water insoluble free-radical polymerizable monomer, and wherein said interior polymer is encapsulated within and bound to the exterior polymer by one or more sulfide linkages and wherein the polymer particle has a diameter within the range of from about 0.1 micron to about 200 microns.

2. A method for preparing a polymer particle having a diameter in the range of from about 0.1 micron to about 200 microns comprising forming an aqueous dispersion by encapsulating at least one water insoluble monomer and at least one free radical source, within a water soluble polymer comprising one or more thiol functional groups, said water soluble polymer being dissolved in an aqueous phase, and polymerizing the at least one water insoluble monomer within the water soluble polymer to form said polymer particle.

3. The method of claim 2 wherein the aqueous phase contains at least one hydroxyl radical source.

4. The method of claim 2 wherein encapsulating the water insoluble monomer comprises subjecting the water soluble polymer to ultrasonic irradiation.

5. The method of claim 2 wherein encapsulating the water insoluble monomer within the water soluble polymer comprises the rise of mechanical mixing.

6. The method of claim 2 wherein encapsulating the water insoluble monomer within the water soluble polymer further comprises the addition of a redox initiator system.

7. The method of claim 2 wherein the water soluble polymer is a protein.

8. The method of claim 2 wherein the at least one water insoluble monomer is selected from the group consisting of vinyl aromatic compounds, vinyl ethers, vinyl esters of a carboxylic acid and vinyl dicarboxylic acids.

9. The method of claim 2 wherein the at least one water insoluble monomer is a polyethylenically unsaturated monomer.

10. The method of claim 2 wherein the aqueous dispersion comprises a surfactant.

11. The method of claim 2 wherein a disulfide cleavage reagent is added following polymerization of the water insoluble monomer or monomers.

12. The method of claim 2 wherein the water soluble polymer is removed by acid hydrolysis from the polymer formed from the water insoluble monomer or monomers.

13. A polymer particle prepared according to the method of claim 2.

14. A polymer particle prepared according to the method of claim 2 wherein the exterior portion has been removed.

15. A polymer particle consisting essentially of:

(i) an exterior water soluble polymer selected from the group consisting of naturally occurring proteins comprising one or more thiol functional group, acrylic polymers comprising one or more thiol functional group, and methacrylic polymers comprising one or more thiol functional group, and

(ii) an interior polymer,

wherein the interior polymer is formed from at least one water insoluble free-radical polymerizable monomer, and wherein said interior polymer is encapsulated within and bound to the exterior polymer by one or more sulfide linkages, and wherein the polymer particle has a diameter within the range of from about 0.1 micron to about 200 microns.