Magnetic resonance imaging assisted cryosurgery

• US 5,433,717 A
• Filed: 03/23/1993
• Issued: 07/18/1995
• Est. Priority Date: 03/23/1993
• Status: Expired due to Term

• Current Assignee: Regents of the University of California (University of California)
• Original Assignee: Regents of the University of California (University of California)
• Inventors: Wong, Sam, Rubinsky, Boris, Gilbert, John, Pease, Grant, Roos, Mark
• Primary Examiner(s): Aschenbrenner, Peter A.
• Assistant Examiner(s): PEFFLEY, MICHAEL F
• Application Number:
  US08/035,455
• Time in Patent Office: 847 Days
• Field of Search: 606/20-26, 128/653.2, 128/653.5
• US Class Current: 606/20
• CPC Class Codes: A61B 18/02 by cooling, e.g. cryogenic techniques devices for cooling specific reflex points of the body within cell-life limits A61H39/06
• CPC Class Codes: A61B 2018/0262 using a circulating cryogenic fluid
• CPC Class Codes: A61B 2090/374 NMR or MRI
• CPC Class Codes: A61B 90/10 for stereotaxic surgery, e.g. frame-based stereotaxis
• CPC Class Codes: G01R 33/28 Details of apparatus provided for in groups G01R33/44 - G01R33/64
• CPC Class Codes: G01R 33/56308 Characterization of motion or flow; Dynamic imaging

Abstract

Methods and apparatus for magnetic resonance imaging (MRI) assisted cryosurgery. Optimal probe placements and cooling parameters are calculated prior to cryosurgery using MRI data. A MRI compatible cryoprobe and a stereotactic probe positioning device are provided. The resolution of MR images is enhanced by mounting a radio frequency MR coil on the intracorporeal end of a cryoprobe. During cryosurgery the temperature distribution in the frozen region is solved by determining the boundary of the frozen region and solving the heat equation for the known boundary conditions. During cryosurgery the temperature distribution in the unfrozen region is determined by T1 measurements. The process of freezing is controled using information from the solution of the energy equation in the frozen region and temperature measurements in the unfrozen region. After cryosurgery the extent of the tissue damage may be ascertained using phosphorus-31 and/or sodium-23 spectroscopy with a special coil set on the cryosurgical probe.

Claims

1. An apparatus for high-resolution magnetic resonance monitoring of cryosurgery in a subject tissue, comprising:

a magnet producing a magnetic field to which said subject tissue is exposed;

a cryoprobe located in said magnetic field and having an intracorporeal end, an exterior surface, a cavity, an inlet for introduction of a cryogen to said cavity, an outlet for exhaust of said cryogen from said cavity, and a thermally conducting region between said cavity and an active region on a portion of said exterior surface for application to said subject tissue; and

a magnetic resonance radio frequency coil mounted on said cryoprobe within a distance less than several times a diameter of said coil from said active region for providing a magnetic resonance image of said subject tissue.

2. The apparatus of claim 1 wherein said magnetic resonance frequency coil is located within a distance less than said diameter from said active region of said cryoprobe.

3. The apparatus of claim 1 wherein said coil is tuned for proton magnetic resonance imaging.

4. The apparatus of claim 1 wherein said coil is tuned for sodium magnetic resonance imaging.

5. The apparatus of claim 1 wherein said coil is tuned for phosphorous magnetic resonance imaging.

6. A surface probe, comprising:

a cryoprobe having an intracorporeal end and an exterior surface, a cavity, an inlet for introduction of a cryogen to said cavity, an outlet for exhaust of said cryogen from said cavity, and a thermally conducting region between said cavity and an active region on a portion of said exterior surface for application to a subject tissue; and

a first magnetic resonance radio frequency coil mounted on said cryoprobe within a first distance less than several times a diameter of said coil from said active region of said cryoprobe for providing a first magnetic resonance image of said subject tissue.

7. The surface probe of claim 6 wherein said first coil is mounted in said thermally conductive region.

8. The surface probe of claim 7 further including

a coil mount extending laterally from the external surface of said cryoprobe;

and

a second magnetic resonance radio frequency coil mounted on said coil mount and within a second distance less than several times a diameter of said second coil from said active region for providing a second magnetic resonance image of said subject tissue.

9. The surface probe of claim 6 further including a coil mount extending laterally from the external surface of said cryoprobe, said first coil mounted on said coil mount.