Imidazopyridines as serotonergic 5-HT.sub.3 antagonists
First Claim
1. A compound of the formula ##STR40## the stereoisomers and pharmaceutically acceptable salts thereof, wherein R1 is H or C1-6 alkyl and R2 is H or halogen;
- Y represents NH or 0; and
wherein k is 1, 1 is 1, j is 0 to 4 and one of R'"'"'3 and R'"'"'4 is H, C1-6 alkyl, phenyl or phenyl-C1-3 alkyl, which phenyl moieties may be optionally substituted by C1-6 alkyl, C1-6 alkoxy, CF3 or halogen and the other of R'"'"'3 and R'"'"'4 is H or C1-6 alkyl.
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Abstract
The imidazopyridines compounds of the present invention are serotonergic 5-HT3 antagonists. As such they are useful for the treatment of humans and animals wherein antagonism of 5-HT3 receptors is beneficial. Therapy is indicated for, but not limited to, the treatment of anxiety, psychoses, depression (especially depression accompanied by anxiety), cognitive disorders, substance abuse dependence and withdrawal, gastrointestinal motility disturbancies (including esophageal reflux, dyspepsia, gastric stasis, irritable bowel syndrome), emesis caused by chemotherapeutic agents, and visceral pain. Additionally, the compounds of the present invention may find utility as enhancers of nasal absorption of bioactive compounds.
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Citations
8 Claims
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1. A compound of the formula ##STR40## the stereoisomers and pharmaceutically acceptable salts thereof, wherein R1 is H or C1-6 alkyl and R2 is H or halogen;
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Y represents NH or 0; and wherein k is 1, 1 is 1, j is 0 to 4 and one of R'"'"'3 and R'"'"'4 is H, C1-6 alkyl, phenyl or phenyl-C1-3 alkyl, which phenyl moieties may be optionally substituted by C1-6 alkyl, C1-6 alkoxy, CF3 or halogen and the other of R'"'"'3 and R'"'"'4 is H or C1-6 alkyl. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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Specification