Non-invasive near-infrared quantitative measurement instrument

• US 5,436,455 A
• Filed: 08/16/1993
• Issued: 07/25/1995
• Est. Priority Date: 06/27/1990
• Status: Expired due to Term

• Current Assignee: Futrex, Inc.
• Original Assignee: Futrex, Inc.
• Inventors: Mastrototaro, John J., Frischmann, Joseph K., Rosenthal, Robert D., Quintana, Reynaldo
• Primary Examiner(s): Dzierzynski, Paul M.
• Assistant Examiner(s): HANIG, RICHARD E
• Application Number:
  US08/106,758
• Time in Patent Office: 708 Days
• Field of Search: 250/341, 250/339, 250/343, 256/39, 128/633
• US Class Current: 250/339.12
• CPC Class Codes: A61B 5/02422 within occluders
• CPC Class Codes: A61B 5/02433 for infrared radiation
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/14552 Details of sensors specially adapted therefor
• CPC Class Codes: G01N 21/359 using near infrared light

Abstract

An improved near-infrared quantitative analysis instrument is disclosed comprising a removable finger insert which facilitates properly aligning and fitting and individual user'"'"'s finger into the optical system of the analysis instrument. The finger insert according to the present invention also prevents the analysis instrument'"'"'s optical system from being damaged by foreign matter typically introduced by a user'"'"'s finger. The finger insert can also be provided with filters which will enable the insert to be used to as an optical standard for the analysis instrument.

Claims

1. A near-infrared quantitative analysis instrument for non-invasive measurement of a blood analyte present in a body part of a subject, said analysis instrument comprising:

(a) introducing means including a near-infrared energy source for introducing near-infrared energy into blood present in a body part of a subject;

(b) detecting means for detecting near-infrared energy emerging from the body part;

(c) a housing means for housing at least said introducing means and said detecting means, said housing means comprising a chamber means for enabling said body part of said subject to be exposed to said near-infrared energy, said introducing means and said detecting means being positioned about said chamber means such that near-infrared energy emitted by said introducing means is receivable by said detecting means;

(d) an insert means for receiving said body part of said subject, including means for semi-permanently engaging said chamber means, said insert means being semi-permanently engaged with said chamber means prior to receiving said body part of said subject; and

(e) processing means for calculating an electrical signal from said detection means into a signal indicative of the quantity of said blood analyte present in the blood of the subject.

2. A near-infrared quantitative analysis instrument as set forth in claim 1, wherein said insert means comprises:

a baffle means for covering, in a first normally-closed position, an external opening of said insert means through which said body part is received by said insert means;

means for causing said baffle means to withdraw to a second open position exposing said external opening of said insert means upon contact of said body part with said baffle means; and

means for causing said baffle means to return to said first normally-closed position upon withdrawal of said body part from said insert means.

3. A near-infrared quantitative analysis instrument as set forth in claim 2, wherein said means for causing said baffle means to withdraw comprises at least one vertical track disposed in said insert means and engaging with said baffle means.

4. A near-infrared quantitative analysis instrument as set forth in claim 2, wherein said means for causing said baffle means to return to said first normally-closed position comprises at least one spring connected between said insert means and said baffle means and biasing said baffle means toward said normally-closed position.

5. A near-infrared quantitative analysis instrument as set forth in claim 3, wherein said means for causing said baffle means to return to said first normally-closed position comprises at least one spring connected between said insert means and said baffle means and biasing said baffle means toward said normally-closed position.

6. A near-infrared quantitative analysis instrument as set forth in claim 2, further comprising diaphragm means disposed around said external opening for engaging said body part when inserted into said insert means.

7. A near-infrared quantitative analysis instrument as set forth in claim 1, further including a lens disposed in said chamber means for focusing near-infrared energy from said energy source.

8. A near-infrared quantitative analysis instrument as set forth in claim 7, further including at least one diffuser means disposed in said chamber means for diffusing near-infrared energy passing through said lens.

9. A near-infrared quantitative analysis instrument for non-invasive measurement of a blood analyte present in a body part of a subject, said analysis instrument comprising:

(a) introducing means including a near-infrared energy source for introducing near-infrared energy into blood present in a body part of a subject;

(b) detecting means for detecting near-infrared energy emerging from the body part;

(c) chamber means for enabling said body part of said subject to be exposed to said near-infrared energy, said introducing means and said detecting means being positioned about said chamber means such that near-infrared energy emitted by said introducing means is receivable by said detecting means;

(d) an insert means, located within said chamber means, for receiving said body part of said subject, including

a baffle means for covering, in a first normally-closed position, an external opening of said insert means through which said body part is received by said insert means,

means for causing said baffle means to withdraw to a second open position exposing said external opening of said insert means upon contact of said body part with said baffle means, and

means for causing said baffle means to return to said first normally-closed position upon withdrawal of said body part from said insert means; and

(e) processing means for calculating an electrical signal from said detection means into a signal indicative of the quantity of said blood analyte present in the blood of the subject.

10. A near-infrared quantitative analysis instrument as set forth in claim 9, wherein said means for causing said baffle means to withdraw comprises at least one vertical track disposed in said insert means and engaging with said baffle means.

11. A near-infrared quantitative analysis instrument as set forth in claim 9, wherein said means for causing said baffle means to return to said first normally-closed position comprises at least one spring connected between said insert means and said baffle means and biasing said baffle means toward said normally-closed position.

12. A near-infrared quantitative analysis instrument as set forth in claim 10, wherein said means for causing said baffle means to return to said first normally-closed position comprises at least one spring connected between said insert means and said baffle means and biasing said baffle means toward said normally-closed position.

13. A near-infrared quantitative analysis instrument as set forth in claim 9, further comprising diaphragm means disposed around said external opening for engaging said body part when inserted into said insert means.

14. A near-infrared quantitative analysis instrument as set forth in claim 9, further including a lens disposed in said chamber means for focusing nearinfrared energy from said energy source.

15. A near-infrared quantitative analysis instrument as set forth in claim 14, further including at least one diffuser means disposed in said chamber means for diffusing near-infrared energy passing through said lens.