Perfluorocarbon associated gas exchange

• US 5,437,272 A
• Filed: 05/01/1991
• Issued: 08/01/1995
• Est. Priority Date: 05/01/1991
• Status: Expired due to Fees

• Current Assignee: University of Pittsburgh of The Commonwealth System of Higher Education
• Original Assignee: Alliance Pharmaceutical Corporation
• Inventors: Fuhrman, Bradley P.
• Primary Examiner(s): Burr, Edgar S.
• Assistant Examiner(s): Lewis, Aaron J.
• Application Number:
  US07/694,290
• Time in Patent Office: 1,553 Days
• Field of Search: 128/204.18, 128/913, 128/203.12
• US Class Current: 128/203.12
• CPC Class Codes: A61M 16/0054 Liquid ventilation
• CPC Class Codes: A61M 16/0833 T- or Y-type connectors, e.g. Y-piece
• CPC Class Codes: A61M 16/0841 for sampling
• CPC Class Codes: A61M 2016/0027 pressure meter
• CPC Class Codes: A61M 2202/0476 Oxygenated solutions
• CPC Class Codes: A61P 11/00 Drugs for disorders of the respiratory system
• CPC Class Codes: Y10S 128/913 Breathable liquids

Abstract

Method and means for maintaining respiratory gas exchange, by introducing into the pulmonary air passages of a mammalian host a volume of perfluorocarbon liquid substantially equivalent to the pulmonary functional residual capacity of the host, maintaining respiratory gas exchange in the perfluorocarbon liquid-laden pulmonary air passages by continuous positive pressure breathing with a conventional respirator, for up to an hour or more, and thereafter evaporating the perfluorocarbon liquid from the pulmonary air passages. Useful for treating pulmonary surfactant deficiency or dysfunction.

Claims

1. A method for maintaining respiratory gas exchange, comprising the steps of:

first introducing into the pulmonary air passages of a mammalian host a volume of perfluorocarbon liquid from about 50% to not more than about 100% of the pulmonary functional residual capacity of the host; and

then physically admixing a volume of breathing gas with said introduced volume of perfluorocarbon liquid in the pulmonary air passages whereby said breathing gas forms bubbles inside said liquid-containing pulmonary air passages so that oxygenation of said perfluorocarbon liquid takes place in vivo, said admixing resulting when said host takes multiple breaths of a breathing gas.

2. The method of claim 1, wherein continuous positive pressure gas breathing is provided into a patient'"'"'s perfluorocarbon liquid-containing pulmonary air passages by a volume-regulated, timed-cycle gas respirator or a pressure-limited, timed-cycle gas respirator.

3. The method of claim 1, wherein the volume of perfluorocarbon liquid is maintained substantially equivalent to the pulmonary functional residual capacity of a host throughout the treatment period.

4. The method of claim 1, wherein after the treatment period the perfluorocarbon liquid is removed from a patient'"'"'s air passages by evaporation.

5. The method of claim 1, wherein the perfluorocarbon liquid comprises a pharmacologic or diagnostic agent.

6. The method of claim 1 wherein the volume of perfluorocarbon liquid introduced into a patient'"'"'s pulmonary air passages is at least about 1/2 of the pulmonary functional residual capacity of the host.

7. The method of claim 1 wherein the volume of perfluorocarbon liquid introduced into a patient'"'"'s pulmonary air passages is at least about 3/4 of the pulmonary functional residual capacity of the host.

8. The method of claim 1, wherein said breathing gas is moved into and out of the host'"'"'s lungs by a gas ventilator.

9. The method of claim 1, wherein said perfluorocarbon liquid is halogenated.

10. The method of claim 1, wherein said perfluorocarbon liquid is perfluorooctyl bromide.

11. The method of claim 1, wherein said introducing step is performed on a host having pulmonary surfactant deficiency or dysfunction.

12. The method of claim 1, wherein said introducing step is performed on a host in need of resuscitation.

13. The method of claim 12, wherein said resuscitation is cardiopulmonary resuscitation.

14. A device for regulating fluid flow during perfluorocarbon associated gas exchange, comprising:

first and second conduits having distal and proximal ends,

an endotracheal tube,

a chamber adapted for establishing fluid communication between said endotracheal tube and said conduits, said chamber interposed between said conduits and said endotracheal tube, at least one valve connected to said conduits to reversibly establish fluid communication between said chamber and either the proximal end of the first but not the second conduit, or the proximal end of the second but not the first conduit,

means associated with said first conduit to introduce and remove a perfluorocarbon liquid to and from said chamber and into a lung,

and means associated with said second conduit to introduce and remove breathing gas separate and apart from said perfluorocarbon liquid to and from said chamber to permit a patient into whom the endotracheal tube is introduced to breathe a breathing gas into and out of perfluorocarbon-containing pulmonary passages into which said perfluorocarbon liquid has been introduced by said device.

15. The device of claim 14, wherein the first conduit comprises first, second, and third channels having proximal ends that collectively establish fluid communication with the chamber as regulated by the valve means.

16. The device of claim 14, wherein the second conduit comprises a single channel having an aperture to the ambient environment.

17. The device of claim 16, wherein the valve means opens the aperture to the ambient environment when fluid communication is established between the chamber and the first but not the second conduit, and closes the aperture when fluid communication is established between the chamber and the second but not the first conduit.

18. A system for implementing perfluorocarbon associated gas exchange, comprising:

a device for first introducing perfluorocarbon liquid into a patient'"'"'s pulmonary air passages,

a gas ventilator for maintaining respiratory gas exchange in a patient'"'"'s perfluorocarbon liquid-containing pulmonary air passages including means for secondly introducing and removing multiple breaths of breathing gas into said passages during a treatment period separate and apart from said introduction of said perfluorocarbon liquid so that said breathing gas physically admixes with said perfluorocarbon liquid in said pulmonary air passages, of a patient whereby a patient'"'"'s pulmonary air passages simultaneously contain both said breathing gas and said perfluorocarbon liquid, and

a device operably associated with both said introducing device and said gas ventilator for regulating the aforesaid introduction of liquid and introduction and removal of gas during the treatment period.