Method and apparatus for prediction of sudden cardiac death by simultaneous assessment of autonomic function and cardiac electrical stability
First Claim
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1. A method of assessing cardiac vulnerability comprising the steps of:
- sensing a plurality of ECG signals from a plurality of sites adjacent a heart;
analyzing an amplitude of beat-to-beat alternation in T-waves of successive R-R intervals of at least one of said ECG signals to obtain an alternans measure;
analyzing a magnitude of heart rate variability in successive R-R intervals of at least one of said ECG signals to obtain a heart rate variability measure;
analyzing a magnitude of dispersion of repolarization in a QT interval across at least two of said plurality of ECG signals to obtain a dispersion measure; and
simultaneously analyzing said alternans measure, said heart rate variability measure and said dispersion measure to assess cardiac vulnerability.
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Abstract
A method and apparatus for predicting susceptibility to sudden cardiac death simultaneously assessing cardiac electrical stability and autonomic influence. Cardiac electrical stability is assessed by analyzing at least one of a beat-to-beat alternation in a T-wave of an ECG of a patient'"'"'s heart and dispersion of repolarization in the ECG of the patient'"'"'s heart. Autonomic influence on the patient'"'"'s heart is assessed by analyzing at least one of a magnitude of heart rate variability in the ECG of the patient'"'"'s heart and baroreceptor sensitivity.
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Citations
29 Claims
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1. A method of assessing cardiac vulnerability comprising the steps of:
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sensing a plurality of ECG signals from a plurality of sites adjacent a heart; analyzing an amplitude of beat-to-beat alternation in T-waves of successive R-R intervals of at least one of said ECG signals to obtain an alternans measure; analyzing a magnitude of heart rate variability in successive R-R intervals of at least one of said ECG signals to obtain a heart rate variability measure; analyzing a magnitude of dispersion of repolarization in a QT interval across at least two of said plurality of ECG signals to obtain a dispersion measure; and simultaneously analyzing said alternans measure, said heart rate variability measure and said dispersion measure to assess cardiac vulnerability. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method of predicting susceptibility to sudden cardiac death, comprising the steps of:
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(a) analyzing at least one of a beat-to-beat alternation in a T-wave of an ECG of a patient'"'"'s heart and dispersion of repolarization in said ECG of the patient'"'"'s heart to assess cardiac electrical stability; and (b) analyzing at least one of a magnitude of heart rate variability in said ECG of the patient'"'"'s heart and baroreceptor sensitivity to assess autonomic influence on the patient'"'"'s heart, provided that alternation and heart rate variability are not analyzed in combination without at least one of dispersion and baroreceptor sensitivity also being analyzed; and (c) performing steps (a) and (b) simultaneously to assess the patient'"'"'s risk of sudden cardiac death. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21)
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22. An apparatus for predicting susceptibility to sudden cardiac death, comprising:
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first means for analyzing at least one of a beat-to-beat alternation in a T-wave of an ECG of a patient'"'"'s heart and dispersion of repolarization in said ECG of the patient'"'"'s heart to assess cardiac electrical stability; and second means for analyzing at least one of a magnitude of heart rate variability in said ECG of the patient'"'"'s heart and baroreceptor sensitivity to assess autonomic influence on the patient'"'"'s heart, provided that alternation and heart rate variability are not analyzed in combination with at least one of dispersion and baroreceptor sensitivity also be analyzed; and third means for simultaneously analyzing assessment of cardiac electrical stability from said first means and autonomic influence on the patient'"'"'s heart from said second means to predict the patient'"'"'s risk of sudden cardiac death. - View Dependent Claims (23, 24, 25, 26, 27, 28, 29)
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Specification