Sterilization of tissue implants using iodine
First Claim
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1. A method for sterilizing a medical device intended for implantation inside the body of a mammal comprising the steps of:
- providing an implant comprised at least in part of excised proteinaceous tissue; and
incubating said implant in a germicidal solution comprising elemental iodine at a concentration, a temperature, and for a time effective to sterilize said implant without damaging said implant, said germicidal solution having a pH between about 5.0-6.8.
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Abstract
The present invention provides an iodine-based solution, and a method of using that solution, which sterilizes tissue implants without denaturing the proteins in the implant and without inducing calcification of the implant in vivo. Preferably, the tissue implants sterilized using the present invention are fixed without using glutaraldehyde. Most preferably, the tissue implants are fixed by photooxidation.
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12 Claims
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1. A method for sterilizing a medical device intended for implantation inside the body of a mammal comprising the steps of:
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providing an implant comprised at least in part of excised proteinaceous tissue; and incubating said implant in a germicidal solution comprising elemental iodine at a concentration, a temperature, and for a time effective to sterilize said implant without damaging said implant, said germicidal solution having a pH between about 5.0-6.8. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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Specification