Endotracheal tube adapted for aerosol generation at distal end thereof

• US 5,438,982 A
• Filed: 10/19/1993
• Issued: 08/08/1995
• Est. Priority Date: 03/10/1992
• Status: Expired due to Term

• Current Assignee: Neil R. Macintyre
• Original Assignee: Neil R. Macintyre
• Inventors: MacIntyre, Neil R.
• Primary Examiner(s): Asher, Kimberly L.
• Application Number:
  US08/139,636
• Time in Patent Office: 658 Days
• Field of Search: 128/200.14, 128/203.12, 128/207.14, 128/207.15, 128/911, 128/912
• US Class Current: 128/207.14
• CPC Class Codes: A61M 11/06 of the injector type
• CPC Class Codes: A61M 15/00 Inhalators drug delivery in endotracheal tubes A61M16/04
• CPC Class Codes: A61M 16/04 Tracheal tubes catheters in general A61M25/00
• CPC Class Codes: A61M 16/0463 combined with suction tubes, catheters or the like; Outside connections
• CPC Class Codes: A61M 16/0486 Multi-lumen tracheal tubes

Abstract

An endotracheal tube adapted for aerosol generation at the distal end thereof and which is a modification of existing endotracheal tubes. The improved tube incorporates first and second conduits along the length thereof in order to deliver a liquid to be aerosolized and a high velocity gas at the distal end of the endotracheal tube so as to create an aerosol within the lungs. The distal end of the gas conveying catheter is configured to direct the high velocity gas transported therethrough across the pathway of the liquid solution exiting the distal end of the first conduit to facilitate the creation of an aerosol for high efficiency delivery of the liquid solution.

Claims

1. An endotracheal tube for aerosol delivery of a selected liquid solution to the lungs comprising:

a tubular member for ventilating a patient comprising a distal end for insertion into the trachea of a patient and a proximal end adapted for introduction of a breathable gas into said tubular member;

a first conduit for delivery of a selected liquid solution to the lungs having a proximal end terminating adjacent the proximal end of said tubular member and a distal end terminating adjacent the distal end of said tubular member, said first conduit extending substantially along the length of said tubular member; and

a second conduit for high velocity delivery of a gas having a proximal end terminating adjacent the proximal end of said tubular member and a distal end terminating adjacent the distal end of said tubular member, said second conduit extending substantially along the length of said tubular member, said second conduit comprising means for directing high velocity gas across a liquid solution exiting the distal end of said first conduit and thereby creating an aerosol.

2. An endotracheal tube according to claim 1 wherein said first and second conduits are embedded within the wall of said tubular member.

3. An endotracheal tube according to claim 2 wherein said first and second conduits are positioned adjacent each other within the wall of said tubular member.

4. An endotracheal tube according to claim 1 wherein said first and second conduits terminate between about 1.0-2.0 centimeters before the distal end of said tubular member and in fluid communication with the internal passageway defined by said tubular member.

5. An endotracheal tube according to claim 1 wherein said endotracheal tube creates an aerosol at the distal end thereof having a particle size between about 1.0-5.0 micrometers.

6. The endotracheal tube of claim 1 wherein said directing means comprises:

an exit aperture of said second conduit oriented relative to said pathway to nebulize said liquid solution.

7. The endotracheal tube of claim 1 wherein said directing means comprises:

the distal end of said second conduit being less than 2 centimeters from the distal end of the first conduit.

8. The endotracheal tube of claim 1 wherein said directing means comprises:

an exit aperture of said second conduit being angled toward the pathway.

9. The endotracheal tube of claim 8 wherein the exit aperture is obliquely angled toward the pathway.

10. An endotracheal tube for aerosol delivery of a selected liquid solution to the lungs comprising:

a tubular member for ventilating a patient comprising a distal end for insertion into the trachea of a patient and a proximal end adapted for introduction of a breathable gas into said tubular member;

a first conduit for delivery of a selected liquid solution to the lungs having a proximal end terminating adjacent the proximal end of said tubular member and a distal end terminating adjacent the distal end of said tubular member, said first conduit extending substantially along the length of said tubular member and being embedded within the wall thereof; and

a second conduit embedded within the wall of said tubular member adjacent said first conduit for high velocity delivery of a gas and having a proximal end terminating adjustment the proximal end of said tubular member and a distal end terminating adjacent the distal end of said tubular member, said second conduit extending substantially along the length of said tubular member and the distal end thereof being less than 2 centimeters from the distal end of the first conduit and having a configuration that directs high velocity gas across a liquid solution exiting the distal end of said first conduit and therefor creating an aerosol.

11. An endotracheal tube according to claim 10 wherein said first and second conduits terminate between about 1.0-2.0 centimeters before the distal end of said tubular member and in fluid communication with the internal passageway defined by said tubular member.

12. An endotracheal tube according to claim 10 wherein said endotracheal tube creates an aerosol at the distal end thereof having a particle size between about 1.0-5.0 micrometers.

13. A method for efficient aerosol delivery of a selected liquid medicine solution to the lungs of an intubated patient comprising:

(a) inserting an endotracheal-type tube into the trachea of a patient wherein said tube comprises a distal end for insertion into the trachea and a proximal end for introduction of a breathable gas into said tube, said tube further comprising relatively smaller diameter first and second conduits having particular configurations and extending substantially along the length of said tube, wherein each of said first and second conduits comprises a proximal end and a distal end generally corresponding to the proximal and distal ends of said tube and the distal ends of said first and second conduits are in fluid communication with the interior of the distal end of said tube;

(b) delivering a selected liquid medication solution to the lungs by introducing the liquid into the distal end of said tube by said first conduit; and

(c) delivering a high velocity gas to the distal end of said tube by said second conduit and angling the gas across the pathway of the liquid medicine solution via the configurations of the first and second conduits so as to create an aerosol.

14. The method of claim 13 in which the aerosol is directed into the interior of said tube.

15. The method of claim 13 further comprising the step of:

mixing the medication solution.

16. The method of claim 13 further comprising the step of:

pumping the medication solution through the first conduit.

17. The method of claim 16 in which the pumping step is at a constant rate.

18. The method of claim 13 further comprising the step of:

attaching a gas source to the proximal end of the second conduit.

19. The method of claim 13 further comprising the step of:

producing an aerosol in the trachea.

20. The method of claim 13 in which the aerosol solution has a virtual 100% efficiency of delivery.

21. The method of claim 13 in which the delivery step is further characterized as producing an aerosol of the liquid medication having a particle size of about 1.0 to 5.0 micrometers.

22. In combination:

an endotracheal tube for ventilating a patient, said endotracheal tube having;

a proximal end, a distal end, and a tubular member extending therebetween, said tubular member comprised of a wall defining an internal passageway therethrough;

a first lumen for delivery of a liquid medicine, said first lumen extending from adjacent the proximal end to adjacent the distal end, said first lumen communicating with a first distal exit aperture located close to the distal end; and

a second lumen for delivery of a gas, said second lumen extending from adjacent the proximal end to adjacent the distal end, said second lumen communicating with a second distal exit aperture located close to the distal end, said second exit aperture oriented relative to the first exit aperture and having a configuration that directs a flow of gas exiting from the second exit aperture across liquid medicine exiting the first exit aperture, whereby liquid medicine delivered through the first exit aperture is aerosolized.

23. The invention of claim 22 wherein the first lumen and the second lumen communicate with the internal passageway.

24. The invention of claim 22 in which the first exit aperture and the second exit aperture are substantially adjacent to each other.

25. The invention of claim 22 in which the first exit aperture and the second exit aperture are less than 2 centimeters apart.

26. The invention of claim 22 in which the first exit aperture and the second exit aperture are less than 1 centimeter apart.

27. The invention of claim 22 in which the first exit aperture and the second exit aperture are less than 2 centimeters from a distal end of the endotracheal tube.

28. The invention of claim 22 in which the first exit aperture and the second exit aperture are less than 1 centimeter from the distal end of the endotracheal tube.

29. The invention of claim 22 wherein said first lumen is located in a first catheter.

30. The invention of claim 29 wherein said second lumen is located in a second catheter.

31. The invention of claim 22 in which said first lumen is located in a first catheter and said second lumen is located in a second catheter and further wherein said first catheter and said second catheter are side-by-side.

32. The invention of claim 31 wherein said first catheter and said second catheter are embedded in said wall.

33. The invention of claim 22 wherein said first lumen is incorporated in said wall.

34. The invention of claim 22 wherein said second lumen is incorporated in said wall.