Flexible diaphragm tonometer

• US 5,439,001 A
• Filed: 11/17/1993
• Issued: 08/08/1995
• Est. Priority Date: 11/17/1993
• Status: Expired due to Term

• Current Assignee: Carefusion 303 Incorporated (Becton, Dickinson & Co), Rutgers University
• Original Assignee: Ivax Corporation (Teva Pharmaceutical Industries, Ltd.)
• Inventors: Butterfield, Robert D., Drzewiecki, Gary M.
• Primary Examiner(s): Cohen, Lee S.
• Assistant Examiner(s): NASSER, ROBERT L
• Application Number:
  US08/154,801
• Time in Patent Office: 629 Days
• Field of Search: 128/672, 128/673, 128/675, 128/687, 128/690, 128/748, 73/723
• US Class Current: 600/485
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/02233 Occluders specially adapted therefor tourniquets A61B17/132

Abstract

A pressure waveform monitor for non-invasively monitoring the pressure waveform inside a vessel, such as an artery, includes a flexible diaphragm extended across an opening of a container containing a fluid. The flexible diaphragm is placed against tissue surrounding an artery such that arterial pressure causes a deflection in the diaphragm. A deflection in the diaphragm causes the fluid to be redistributed throughout the container which is effectively divided into an array of volume compartments. The relative volume distribution is determined through impedance plethysmography. The diaphragm is maintained in a calibrated position by maintaining the array of volume compartments at relatively unchanged volumes. When the relative volumes remain essentially unchanged, calibrated tonometry is possible. The pressure within the container is then used to determine the pulse waveform and the pressure within the artery.

Claims

1. A pressure waveform monitor for noninvasively monitoring the pressure waveform inside a vessel, comprising:

a container having an opening;

a flexible diaphragm extended across said opening such that said container is effectively closed by said diaphragm, said diaphragm being adapted to bend responsively to vessel pressure when said diaphragm is placed against tissue covering the vessel;

fluid disposed within said closed container;

means for altering a volume of fluid in said container in response to bending of said diaphragm;

where said altering is one of increasing or decreasing; and

means for determining a pressure within said container.

2. The monitor of claim 1, wherein said container has three sidewalls, a first sidewall generally parallel to and opposite said diaphragm and second and third sidewalls generally perpendicular to said first sidewall, one end of said second and third sidewalls defining said opening.

3. The monitor of claim 1 wherein said container is formed of a lightweight plastic.

4. The monitor of claim 1, wherein said diaphragm comprises a thin sheet of polyurethane maintained across said opening such that a leakproof seal is maintained across said opening.

5. The monitor of claim 1, wherein said fluid comprises a noncompressible electrically conductive solution.

6. The monitor of claim 1, wherein said fluid comprises a saline solution.

7. The monitor of claim 1, wherein said fluid comprises a gel.

8. The monitor of claim 1, wherein said fluid comprises a gas.

9. The monitor of claim 1, wherein said volume altering means comprises:

means for dividing said container into a plurality of volume compartments;

means for supplying electrical current to said fluid within said container; and

means for determining the respective fluid volumes within each said volume compartment, using said electrical current.

10. The monitor of claim 9 wherein said dividing means comprises three electrodes positioned within said container such that a pair of electrodes defines a volume compartment, said volume compartments being in relative communication such that said fluid moves freely between said compartments.

11. The monitor of claim 9, wherein said electrical current supplying means comprises a pair of electrodes positioned within said container such that a current signal is passed through said fluid within each volume compartment, respectively.

12. The monitor of claim 9, wherein said fluid volume determining means comprises:

means for determining voltage imparted to the fluid within a volume compartment responsive to said electrical current;

means for producing a volume signal, said volume signal corresponding to a single volume compartment, said volume signal defining the fluid volume within the volume compartment relative to said voltage within the volume compartment; and

means for producing a pulsatile change signal, said pulsatile change signal corresponding to a single volume compartment, said pulsatile change signal defining the change in fluid volume within the volume compartment relative to said voltage caused by said diaphragm bending responsively to vessel pressure.

13. The monitor of claim 12, wherein said voltage determining means comprises:

means for filtering a voltage across a volume compartment to thereby remove any constant offset voltage and for producing a filtered voltage signal; and

means for demodulating the filtered voltage signal to thereby produce a voltage signal that is proportional to the fluid volume within the volume compartment.

14. The monitor of claim 13, wherein said volume signal producing means comprises calibrating and buffering means for calibrating and buffering said voltage signal to thereby produce said volume signal.

15. The monitor of claim 12, wherein said pulsatile change signal producing means comprises:

means for filtering a voltage across a volume compartment to thereby remove any constant offset voltage and for producing a filtered voltage signal;

means for demodulating the filtered voltage signal to thereby produce a voltage signal that is proportional to the fluid volume within the volume compartment;

filtering means for filtering the voltage signal to thereby produce a pulsatile component signal;

means for amplifying the pulsatile component signal; and

means for calibrating the amplified pulsatile component signal to thereby produce said pulsatile change signal.

16. The monitor of claim 9, wherein said volume altering means further comprises an electromechanical transducer coupled to said fluid volume determining means and a reservoir of fluid coupled with said container such that the amount of fluid within said container is altered when said fluid volume determining means indicates that the fluid volumes within each volume compartment are changing undesirably, said fluid amount being altered to effectively maintain each volume compartment relatively unchanged by vessel pulsations.

17. The monitor of claim 1, wherein said pressure determining means comprises a strain gauge bridge amplifier circuit coupled to said container, said circuit producing a pressure voltage signal that is proportional to the fluid pressure within said container.

18. A pressure waveform monitor for noninvasively monitoring the pressure waveform inside a vessel, comprising:

a container having an opening;

a flexible diaphragm extended across said opening such that said container is effectively closed by said diaphragm, said diaphragm having a calibrated position, said diaphragm being adapted to bend responsively to vessel pressure when said diaphragm is placed against tissue adjacent the vessel;

fluid within said closed container;

means for dividing said container into adjacent compartments, said compartments being in relative communication such that said fluid moves freely between said compartments said compartments having respective volumes that are in an essentially fixed ratio when said diaphragm is in said calibrated position;

means for determining individual volumes within each of said compartments when said diaphragm bends responsively to vessel pressure and thereby distributes said fluid throughout said container;

means for supplying additional fluid to said container when the individual volumes of said compartments change relative to each other due to said vessel pressure such that the individual volumes are maintained in a essentially fixed ratio; and

means for determining a pressure within said container when said individual volumes are maintained in an essentially fixed ratio, whereby the pressure waveform within a vessel is determined.

19. A pressure waveform monitor for non-invasively monitoring the pressure waveform inside a vessel, comprising:

a container having an opening;

a flexible diaphragm extended across said opening such that said container is effectively closed by said diaphragm, said diaphragm being adapted to bend responsively to vessel pressure when said diaphragm is placed adjacent tissue overlying the vessel;

fluid disposed within said effectively closed container;

means for dividing said container into a plurality of volume compartments;

means for determining respective fluid volumes within each said volume compartment; and

means for determining a pressure within said container.

20. The monitor of claim 19, wherein said dividing means comprises three electrodes positioned within said container such that a pair of electrodes defines a volume compartment, said volume compartments being in relative communication such that said fluid moves freely between said compartments.

21. The monitor of claim 19, further comprising means for supplying electrical current to said fluid within said container and wherein said means for determining the respective fluid volumes within each said volume compartment utilizes said electrical current.

22. The monitor of claim 21, wherein said electrical current supplying means comprises a pair of electrodes positioned within said container such that a current signal is passed through said fluid within each volume compartment, respectively.

23. The monitor of claim 21, wherein said fluid volume determining means comprises:

means for determining a voltage imparted to the fluid within a volume compartment responsive to said electrical current;

means for producing a volume signal, said volume signal corresponding to a single volume compartment, said volume signal defining the fluid volume within the volume compartment relative to said voltage within the volume compartment; and

means for producing a pulsatile change signal, said pulsatile change signal corresponding to a single volume compartment, said pulsatile change signal defining the change in fluid volume within the volume compartment relative to said voltage caused by said diaphragm bending responsively to vessel pressure.

24. The monitor of claim 19, further comprising means for altering a volume of fluid in said container in response to bending of said diaphragm, wherein said volume altering means comprises an electromechanical transducer coupled to said fluid volume determining means and a reservoir of fluid coupled with said container such that the amount of fluid within said container is altered when said fluid volume determining means indicates that the fluid volumes within each volume compartment are changing undesirably, said fluid amount being altered to effectively maintain each volume compartment relatively unchanged by vessel pulsations.