Magnetic filter with ordered wire array

• US 5,439,586 A
• Filed: 09/15/1993
• Issued: 08/08/1995
• Est. Priority Date: 09/15/1993
• Status: Expired due to Term

• Current Assignee: Terry Fox Laboratory of The British Columbia Cancer Agnecy, University of Southampton
• Original Assignee: Terry Fox Laboratory of The British Columbia Cancer Agnecy, University of Southampton
• Inventors: Richards, Adrian J., Lansdorp, Peter M.
• Primary Examiner(s): Savage, Matthew O.
• Application Number:
  US08/121,098
• Time in Patent Office: 692 Days
• Field of Search: 210/222, 210/223, 210/456, 210/695, 209/224, 209/232
• US Class Current: 210/222
• CPC Class Codes: A61M 1/3618 Magnetic separation
• CPC Class Codes: A61M 1/3627 Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
• CPC Class Codes: B01D 35/06 Filters making use of electricity or magnetism ultrafiltration, microfiltration B01D61/14; electrodialysis, electro-osmosis B01D61/42; devices comprising filters and magnetic separators B03C1/30
• CPC Class Codes: B03C 1/01 by addition of magnetic adjuvants
• CPC Class Codes: B03C 1/032 Matrix cleaning systems
• CPC Class Codes: B03C 1/0335 using coils
• CPC Class Codes: B03C 1/034 characterised by the matrix elements
• CPC Class Codes: B03C 1/288 disposed at the outer circumference of a recipient
• CPC Class Codes: B03C 2201/18 Magnetic separation whereby the particles are suspended in a liquid
• CPC Class Codes: B03C 2201/26 for use in medical applications

Abstract

A device for separating magnetic materials from non-magnetic materials in a sample using an applied magnetic field includes an inverted upstream funnel containing a plurality of longitudinally spaced, non-magnetisable flow-smoothing surfaces extending transversely across the width of the funnel, a coaxial filter chamber coupled to the output end of the upstream funnel having mounted therein an ordered wire array of magnetisable wires and a coaxial downstream funnel containing a plurality of longitudinally spaced, non-magnetisable flow-smoothing surfaces extending transversely across the width of the downstream funnel. The device may be used to separate magnetically labelled materials from samples such as biological samples.

Claims

1. A device for separating magnetic materials from non-magnetic materials in fluid using an applied magnetic field, the device having a longitudinal axis along which fluid flows and comprising:

a) upstream fluid flow expansion and distribution means for expanding and uniformly distributing the fluid flow from a smaller transverse cross-section to a larger transverse cross-section, comprising an inverted upstream funnel with a smaller input end and larger output end, and a plurality of non-magnetisable flow-smoothing surface means extending transversely of the longitudinal axis across the funnel and spaced apart from one another along the longitudinal axis;

b) filter means for magnetically filtering the magnetic materials from the fluid while allowing non-magnetic materials to pass through when a magnetic filed is applied thereto, comprising a filter input and a filter output and a coaxial filter chamber located on the longitudinal axis with the filter input coupled to the output end of the upstream funnel and the filter chamber having mounted therein an ordered array of magnetisable wires; and

c) downstream flow contraction and distribution means for contracting and uniformly distributing the fluid flow from a larger transverse cross-section to a smaller transverse cross-section, comprising a downstream funnel having a larger input end coupled to the filter output and a smaller output end, and a plurality of non-magnetisable flow-smoothing surface means extending transversely of the longitudinal axis across the funnel and spaced apart from one another along the longitudinal axis.

2. The device as defined in claim 1, wherein the funnels are conical and the filter chamber is cylindrical.

3. The device as defined in claim 1, wherein the ordered wire array comprises a stack of magnetisable wire meshes extending transversely of the longitudinal axis.

4. The device defined in claim 3, wherein the wire meshes are made of woven stainless steel wire.

5. The device as defined in claim 3, wherein successive and adjacent meshes are axially rotated relatively to each other.

6. The device as defined in claim 3, wherein the filter means also comprises reinforcing means for reinforcing the ordered wire array against distortion due to fluid flow and applied magnetic field.

7. The device defined in claim 6, wherein the reinforcing means comprises crosslinking means for crosslinking the wires of the ordered wire array, comprising an encapsulating coating applied to the wires at their junctions.

8. The device defined in claim 7, wherein the encapsulating coating is silicone.

9. The device as defined in claim 7, wherein the reinforcing means also comprises mesh support means for supporting the magnetisable meshes of the ordered wire array, comprising a plurality of support wires spaced apart along said longitudinal axis and extending transversely of said longitudinal axis.

10. The device as defined in claim 9, wherein the mesh support means comprises pairs of crossed wires.

11. The device as defined in claim 1, wherein the ordered array extends along the longitudinal axis and comprises a stack of magnetisable wire meshes extending transversely of the longitudinal axis.

12. The device as defined in claim 1, wherein the flow-smoothing surface means comprise smoothing meshes of wire.

13. The device defined in claim 12, wherein the smoothing meshes comprise woven, non-magnetic stainless steel wires.

14. The device as defined in claim 13, wherein the non-magnetic wires are spaced apart by a minimum of 200 μ

m apart.

15. The device as defined in claim 1, wherein the inside surface of the conical funnels are smooth and continuous.

16. The device as defined in claim 1, wherein the flow distribution means also comprise chamfered intersections between the filter chamber and the funnels.