Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor
First Claim
1. A composition for in vivo delivery of a substantially water insoluble pharmacologically active agent,wherein said agent is a solid or liquid substantially completely contained within a polymeric shell,wherein the largest cross-sectional dimension of said shell is no greater than about 10 microns,wherein said polymeric shell comprises a biocompatible polymer which is substantially crosslinked by way of disulfide bonds, andwherein said polymeric shell containing pharmacologically active agent therein is suspended in a biocompatible aqueous liquid.
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Abstract
In accordance with the present invention, there are provided compositions for the in vivo delivery of substantially water insoluble pharmacologically active agents (such as the anticancer drug taxol) in which the pharmacologically active agent is delivered in a soluble form or in the form of suspended particles. In particular, the soluble form may comprise a solution of pharmacologically active agent in a biocompatible dispersing agent contained within a protein walled shell. Alternatively, the protein walled shell may contain particles of taxol. In another aspect, the suspended form comprises particles of pharmacologically active agent in a biocompatible aqueous liquid.
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17 Claims
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1. A composition for in vivo delivery of a substantially water insoluble pharmacologically active agent,
wherein said agent is a solid or liquid substantially completely contained within a polymeric shell, wherein the largest cross-sectional dimension of said shell is no greater than about 10 microns, wherein said polymeric shell comprises a biocompatible polymer which is substantially crosslinked by way of disulfide bonds, and wherein said polymeric shell containing pharmacologically active agent therein is suspended in a biocompatible aqueous liquid.
Specification