Method of distinguishing among strips for different assays in an automated instrument

• US 5,439,826 A
• Filed: 12/02/1988
• Issued: 08/08/1995
• Est. Priority Date: 12/02/1988
• Status: Expired due to Term

• Current Assignee: BTI Holdings, Inc., Syva Co. (Siemens AG)
• Original Assignee: Biotek Instruments, Inc. (Agilent Technologies, Inc.), Syva Co. (Siemens AG)
• Inventors: Kontorovich, Michael
• Primary Examiner(s): Hollrah, Glennon H.
• Assistant Examiner(s): Burn, Brian M.
• Application Number:
  US07/278,902
• Time in Patent Office: 2,440 Days
• Field of Search: 436/518, 436/43, 436/528, 436/430, 436/531, 436/805, 436/50, 422/63, 422/52, 422/55, 422/67
• US Class Current: 436/50
• CPC Class Codes: B01L 3/5085 for multiple samples, e.g. microtitration plates
• CPC Class Codes: G01N 2035/00772 mechanical or optical code other than bar code
• CPC Class Codes: G01N 35/026 having blocks or racks of reaction cells or cuvettes
• CPC Class Codes: Y10T 436/110833 Utilizing a moving indicator strip or tape
• CPC Class Codes: Y10T 436/112499 with sample on test slide
• CPC Class Codes: Y10T 436/114998 with treatment or replacement of aspirator element [e.g., cleaning, etc.]
• CPC Class Codes: Y10T 436/115831 Condition or time responsive
• CPC Class Codes: Y10T 436/12 Condition responsive control

Abstract

A method of distinguishing between strips for different assays in an automated instrument, wherein characteristics to which the instrument is sensitive are selectively introduced in microwells of individual microstrips which are pretreated with a specific antigen or antibody for a particular test. On each microstrip, the wells having the characteristic collectively define a multi-bit code which corresponds to a particular condition or disease to be tested for. The automated instrument reads the characteristic from the selected wells and thus determines what test is to be conducted. The marks may have optical, radioactive, luminescent, fluorescent, or magnetic characteristics, in accordance with the test to be conducted.

Claims

1. A method for distinguishing among strips for different assays in testing by an automated instrument which performs said testing based on detection of one or more physical characteristics to which said automated instrument is sensitive, said method comprising the following steps:

selectively introducing, in a predetermined order, one of said physical characteristics into wells of the microstrip to which the automated instrument is sensitive, said automated instrument correlating said predetermined order to a particular assay; and

detecting the presence or absence of said introduced characteristic in each of the wells, wherein the elements of said automated instrument which detect said introduced characteristic perform said testing.

2. A method as claimed in claim 1, wherein said characteristic is optical density.

3. A method as claimed in claim 1, wherein said characteristic is reflectance.

4. A method as claimed in claim 1, wherein said characteristic is radioactivity.

5. A method as claimed in claim 1, wherein said characteristic is luminescence.

6. A method as claimed in claim 1, wherein said characteristic is fluorescence.

7. A method as claimed in claim 1, wherein said selectively introducing step comprises the step of introducing a chemical into selected ones of the microstrip wells to imbue those wells with the characteristic.

8. A method as claimed in claim 1, wherein said selectively introducing step comprises the step of placing on the bottom of the wells a mark having said characteristic.

9. A method as claimed in claim 8, wherein said selectively introducing step further comprises the step of placing said marks away from the center of the bottom of the selected wells.

10. A method as claimed in claim 8, wherein said marks are provided by heat stamping.

11. A method as claimed in claim 8, wherein said marks are provide by offset printing.

12. A method as claimed in claim 8, wherein said marks are provided by laser marking.

13. A method as claimed in claim 8, wherein said selectively introducing step comprises the steps of providing an individual carrier for each of said microstrips, and selectively placing said marks on said individual carrier.

14. A method as claimed in claim 1, wherein said detecting step comprises the step of reading a multi-bit code representative of the test to be conducted.

15. A method as claimed in claim 14, wherein said detecting step comprises the step of reading an 8-bit code representative of the test to be conducted.

16. A method as claimed in claim 14, wherein said detecting step comprises the step of reading a 6-bit code representative of the test to be conducted.

17. A method as claimed in claim 2, wherein said detecting step comprises the step of measuring each of said wells at at least one optical wavelength.

18. A method as claimed in claim 17, wherein said detecting step comprises the step of measuring each of said wells at two different optical wavelengths.