Method and apparatus for the non-invasive detection and classification of emboli

• US 5,441,051 A
• Filed: 02/09/1995
• Issued: 08/15/1995
• Est. Priority Date: 02/09/1995
• Status: Expired due to Term

• Current Assignee: Luna Innovations, Inc.
• Original Assignee: Brian Wall, David A. Stump, Ronald E. Hileman
• Inventors: Wall, Brian, Hileman, Ronald E., Stump, David A.
• Primary Examiner(s): MANUEL, GEORGE C
• Application Number:
  US08/386,297
• Time in Patent Office: 187 Days
• Field of Search: 128/661.07, 128/661.08, 128/661.09, 128/661.10, 128/662.02, 128/662.04
• US Class Current: 600/454
• CPC Class Codes: A61B 8/06 Measuring blood flow measuring volume flow in general G01F, e.g. G01F1/66, G01F1/72; measuring speed of fluids in general G01P5/00
• CPC Class Codes: G01S 7/52036 using analysis of echo signal for target characterisation

Abstract

A method and apparatus for ultrasonically detecting an embolus in blood flow includes an ultrasound transducer for transmitting ultrasound pulses into the blood flow being interrogated and receiving reflections from acoustic impedance changes in the body. The reflected signals are converted to an electronic signal representation which is subsequently processed to detect and classify emboli in the blood flow. A short duration, broad bandwidth ultrasound signal is used to preserve the polarity of the reflected signal. The polarity is then used to classify the emboli based on a positive or negative reflection coefficient. Emboli having a negative reflection coefficient are classified as either gaseous or fat particles, and emboli having a positive reflection coefficient are classified as solid particles. The emboli can be further classified based on the amplitude of the reflected signal, or designated features of the time waveform or FFT of the reflected signal.

Claims

1. An ultrasonic pulse echo apparatus for detecting an embolus in blood flow, comprising:

a) at least on ultrasound transducer for transmitting short duration, broad bandwidth ultrasound pulses through a blood vessel so that emboli passing through the vessel are insonified;

b) an ultrasound receiver for receiving echo pulses from an emboli passing through said blood vessel and from surrounding tissue and for converting said echo pulses into an electronic signal representation; and

c) signal processing means for processing said electronic signal representation of said echo pulses to detect the presence of an emboli and to characterize said emboli by determining the polarity of the electronic signal representation of the echo pulses.

2. The pulse echo system of claim 1 wherein said ultrasound transducer has a percent bandwidth greater than 50%.

3. The pulse echo system of claim 2 wherein said ultrasound transducer has a percent bandwidth greater than 80%.

4. The pulse echo system of claim 1 wherein the ultrasound beam covers the entire cross-section of the blood vessel.

5. The pulse echo system of claim 4 including a plurality of ultrasound transducers arranged in an array and operated to sequentially produce adjacent beams that collectively cover the entire cross-section of the blood vessel.

6. The pulse echo system of claim 1 wherein the ultrasound receiver has a frequency response extending below one-fourth the nominal center frequency of the ultrasound transducer to facilitate preservation of the polarity of said echo pulses.

7. The pulse echo system of claim 1 wherein the ultrasound receiver includes time gain compensation to compensate for acoustic attenuation of said ultrasound pulses.

8. The pulse echo system of claim 1 wherein said signal processing means includes a moving target indicator to differentiate echo pulses of said emboli from echo pulses of the surrounding tissue.

9. The pulse echo system of claim 8 wherein said moving target indicator includes a smoothing function for averaging multiple pulse echo sequences.

10. The pulse echo system of claim 1 wherein said signal processing means further characterizes said emboli by size based on the amplitude of said electronic signal representation.

11. The pulse echo system of claim 1 wherein said signal processing means generates a time waveform based on said electronic signal representation of the echo pulses and further characterizes said emboli based upon selected features of said time waveform.

12. The pulse echo system of claim 1 wherein said signal processing means generates a frequency spectrum based on said electronic signal representation of said echo pulses and further characterizes said emboli based upon selected features of said frequency spectrum.

13. The pulse echo system of claim 1 wherein said signal processing means maintains a count of the number of emboli having certain designated characteristics.

14. The pulse echo system of claim 1 wherein said signal processing means includes means to detect motion artifacts.

15. The pulse echo system of claim 14 wherein said signal processing means inhibits detection of emboli when motion artifacts are present.

16. The pulse echo system of claim 1 wherein said signal processing means includes means for detecting electrical interference artifacts.

17. The pulse echo system of claim 16 wherein said signal processing means inhibits detection of emboli when electrical interference artifacts are present.

18. The pulse echo system of claim 1 further including means for classifying said emboli based upon selected features of said electronic signal representation of the echo pulses from said emboli.

19. The pulse echo system of claim 1 further including a display for providing a visual representation of the echo pulses from the emboli.

20. The pulse echo system of claim 19 wherein the visual representation of the echo pulse is an amplitude versus time display.

21. The pulse echo system of claim 19 wherein the visual representation of the echo pulse is an amplitude versus frequency display.

22. The pulse echo system of claim 19 wherein the visual representation of th echo pulse is time versus depth display wherein amplitude is represented as brightness.

23. The pulse echo system of claim 1 further includes means for generating an audible signal in response to the detection of an emboli.

24. A method for ultrasonically detecting an embolus in blood flow comprising:

(a) transmitting a short duration, broad bandwidth ultrasound pulse through a blood vessel so that emboli passing through the vessel are insonified;

(b) receiving echo pulses from the emboli passing through the blood vessel and from surrounding tissue at a receiver;

(c) converting the echo pulses into an electronic signal representation;

(d) processing said electronic signal representation of said echo pulses to detect the presence of an emboli; and

(e) characterizing said emboli by determining the polarity of the electronic signal representation of the echo pulses.

25. The detection method of claim 24 wherein the ultrasound pulses transmitted through the blood vessel have a percent bandwidth greater than 50%.

26. The detection method of claim 25 wherein the ultrasound pulses transmitted through the blood vessel have a percent bandwidth greater than 80%.

27. The detection method of claim 24 wherein the ultrasound beam covers the entire cross-section of the blood vessel.

28. The detection method of claim 27 wherein an array of ultrasound pulses are transmitted sequentially, and wherein said array of ultrasound pulses collectively cover the entire cross-section of the blood vessel.

29. The detection method of claim 24 further including the step of detecting abnormal motion and inhibiting detection of emboli when abnormal motion is present.

30. The detection method of claim 24 further including the step of detecting electrical interference and inhibiting detection of emboli when electrical interference is present.

31. The detection and classification method of claim 24 further including the step of characterizing said emboli by size based on the amplitude of said electronic signal representation.

32. The detection and classification method of claim 24 further including the step of generating a time waveform based on said electronic signal representation of the echo pulses and characterizing said emboli based upon selected features of said time waveform.

33. The detection and classification method of claim 24 further including the step of generating a frequency spectrum on said electronic signal representation of said echo pulses and characterizing said emboli based upon said features of said frequency spectrum.

34. The detection and classification method of claim 24 further including the step of maintaining a count of the number of emboli having certain designated characteristics.

35. The detection and classification method of claim 24 further including the step of displaying a visual representation of the echo pulses from the emboli.

36. The detection and classification method of claim 35 wherein the visual representation of the echo pulse is an amplitude versus time display.

37. The detection and classification method of claim 35 wherein the visual representation of the echo pulse is an amplitude versus frequency display.

38. The pulse echo system of claim 35 wherein the visual representation of the echo pulse is a time versus depth display wherein amplitude is represented as darkness.

39. The pulse echo system of claim 24 further including the step of generating an audible signal in response to the detection of an emboli.