Apparatus and method for multiple wavelength of tissue

• US 5,441,053 A
• Filed: 09/15/1992
• Issued: 08/15/1995
• Est. Priority Date: 05/03/1991
• Status: Expired due to Term

• Current Assignee: University of KY Research Foundation
• Original Assignee: University Of Kentucky Research Foundation (University of Kentucky)
• Inventors: Cassis, Lisa A., Lodder, Robert A.
• Primary Examiner(s): Smith, Ruth S.
• Application Number:
  US07/945,020
• Time in Patent Office: 1,064 Days
• Field of Search: 128/664, 128/395-398, 128/633, 128/634, 128/665, 606/3, 606/15, 606/16, 607/88, 607/89, 607/90, 607/92, 607/93
• US Class Current: 600/473
• CPC Class Codes: A61B 5/0086 using infrared radiation

Abstract

An apparatus for analyzing the chemical composition of tissue includes a near infrared light source, a fiber-optic probe, a mechanism for directing the light from the light source onto the tissue and detectors for detecting light reflected by the tissue. The light source transmits an incident beam having a wavelength ranging from 1000 to 2500 nm. A compound parabolic concentrator (CPC) is connected to a distal end of the fiber optic probe to focus or concentrate the wavelengths of light simultaneously and in parallel on a particular spot of tissue. Alternatively, an inverted, substantially conical reflector is positioned to scatter the incident light across the tissue. The method includes the steps of (1) focusing light onto the tissue to be analyzed; (2) detecting light reflected by the tissue; and (3) analyzing the resulting spectra across the full wavelength of the originally focused light. A color image is then produced for subsequent study.

Claims

1. An apparatus for analyzing tissue including arterial lesions, comprising:

a light generating means for transmitting simultaneously and in parallel an incident beam of light having a wavelength range from substantially 1000 to 2500 nm;

means for directing light from said light generating means onto the tissue to be analyzed;

fiber-optic probe means for transmitting light from said light generating means to said light directing means and for receiving light scattered by said tissue;

means for detecting light simultaneously and in parallel across a full wavelength range of substantially 1000 to 2500 nm scattered by said tissue; and

means for analyzing the detected light across a full wavelength range of substantially 1000 to 2500 nm.

said fiber opticprobe means including a centrally located light transmitting strand and a radial array of light receiving strands concentrically positioned around said light transmitting strand, said light transmitting and receiving strands each including a distal end and said distal end of said light transmitting strand projecting beyond said distal ends of said light receiving strands by between 0.1 and 50.0 mm.

2. The apparatus set forth in claim 1, wherein light from said light generating means is of a more limited wavelength range from substantially 1500 to 2100 nm and said means for detecting and analyzing light functions over a more limited wavelength range of substantially 1500 to 2100 nm.

3. The apparatus set forth in claim 1, wherein said light directing means is an inverted substantially conical reflector.

4. The apparatus set forth in claim 3, wherein said inverted substantially conical reflector includes a parabolic sidewall for scattering incident light and focusing light reflected from said tissue.

5. A method of analyzing tissue, comprising the steps of:

focusing simultaneously and in parallel light having a continuous bandwidth range of at least 600 nm within a Wavelength range from substantially 1,000-2,500 nm on said tissue to be analyzed;

detecting simultaneously and in parallel light having said at least 600 nm bandwidth range Within a wavelength range from substantially 1,000-2,500 nm scattered by said tissue; and

analyzing simultaneously and in parallel the detected light having said at least 600 mm bandwidth range within a wavelength range from substantially 1,000-2,500 nm while giving all wavelengths equal weight.

6. The method set forth in claim 5, wherein said light being focused is of a more limited wavelength range from substantially 1500 to 2100 nm and said light detecting and analyzing steps are also carried out over a more limited wavelength range from substantially 1500 to 2100 nm.

7. A method of analyzing arterial endothelium in vivo utilizing a fiber optic probe, comprising the steps of:

introducing said probe into an artery;

focusing simultaneously and in parallel light having a continuous bandwidth range of at least 600 nm within a wavelength range from substantially 1,000-2,500 nm on said arterial endothelium to be analyzed;

detecting simultaneously and in parallel light having said continuous bandwidth range of at least 600 nm within a wavelength range from substantially 1,000-2,500 nm as reflected by said arterial endothelium; and

analyzing simultaneously and in parallel the detected light having said continuous bandwidth range of at least 600 nm within a wavelength range from substantially 1,000-2,500 nm while giving all wavelengths equal weight.

8. The method set forth in claim 7, wherein said light being focused is of a more limited wavelength range from substantially 1500 to 2100 nm and said detecting and analyzing steps are also carried out over a more limited wavelength range from substantially 1000 to 2500 nm.