Microdialysis probes and methods of use
First Claim
1. A microdialysis probe arranged to have a primary probe releasably secured to it to enable the microdialysis probe and the primary probe to be extended as a unit through a common opening into the body of a living being, whereupon the microdialysis probe can be used for selective sampling and/or administration of dialyzable compounds in biological fluids from living tissue within the body of the being and the primary probe can be used for some other function within the body of the being, said microdialysis probe comprising means for releasably mounting said primary probe to said microdialysis probe, a dialysis chamber having a wall formed of a semi-permeable material having a pore size larger than the molecular weight of the dialyzable compounds, an inlet passageway to said chamber and an outlet passageway from said chamber.
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Accused Products
Abstract
A microdialysis probe arranged to have a primary probe, e.g., an electrical probe, secured to it so that the microdialysis probe extends about and is concentric with the primary probe to enable the combined microdialysis probe and the primary probe to be extended as a unit through a common opening into the body of a living being, whereupon the microdialysis probe can be used for selective sampling and/or administration of dialyzable compounds in biological fluids from living tissue within the body of the being and the primary probe can be used for some other function within the body of the being without appreciably injuring adjacent tissue. The microdialysis probe comprises a tube having a lumen therethrough for releasably mounting the primary probe, and at least one dialysis chamber. In one embodiment only a single annular dialysis chamber is provided with the lumen mounting the primary probe extending therethrough. In another embodiment two semi-annular dialysis chambers are provided adjacent each other with the lumen mounting the primary probe extending therethrough. In either case each dialysis chamber comprises a wall formed of a semi-permeable material, an inlet passageway to the chamber and an outlet passageway from the chamber.
132 Citations
30 Claims
- 1. A microdialysis probe arranged to have a primary probe releasably secured to it to enable the microdialysis probe and the primary probe to be extended as a unit through a common opening into the body of a living being, whereupon the microdialysis probe can be used for selective sampling and/or administration of dialyzable compounds in biological fluids from living tissue within the body of the being and the primary probe can be used for some other function within the body of the being, said microdialysis probe comprising means for releasably mounting said primary probe to said microdialysis probe, a dialysis chamber having a wall formed of a semi-permeable material having a pore size larger than the molecular weight of the dialyzable compounds, an inlet passageway to said chamber and an outlet passageway from said chamber.
- 20. A combination microdialysis probe and a primary probe arranged to be extended as a unit through a common opening into the body of a living being, whereupon the microdialysis probe can be used for selective sampling and/or administration of dialyzable compounds in biological fluids from living tissue within the body of the being and the primary probe can be used for some other function within the body of the being, said combination comprising a primary probe and a microdialysis probe comprising a central lumen for mounting said primary probe therein so that said primary probe extends through said microdialysis probe and with said microdialysis probe extending generally concentrically about said primary probe, said dialysis probe additionally comprising a dialysis chamber having an outer wall formed of a semi-permeable material having a pore size larger than the molecular weight of the dialyzable compounds, an inner wall through which said lumen extends, an inlet passageway to said chamber and an outlet passageway from said chamber.
Specification