Forced atrioventricular synchrony dual chamber pacemaker

• US 5,441,523 A
• Filed: 04/12/1994
• Issued: 08/15/1995
• Est. Priority Date: 04/12/1994
• Status: Expired due to Term

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Telectronics Pacing Systems, Inc (Abbott Laboratories Incorporated)
• Inventors: Nappholz, Tibor A.
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): Getzow, Scott M.
• Application Number:
  US08/226,654
• Time in Patent Office: 490 Days
• Field of Search: 607/9, 607/14
• US Class Current: 607/14
• CPC Class Codes: A61N 1/3622 comprising two or more electrodes co-operating with different heart regions
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance

Abstract

A dual chamber cardiac pacemaker is adapted to operate in a forced synchrony pacing mode. The pacemaker senses atrial heartbeats and determines whether the rate of sensed atrial heartbeats is pathological or physiological. For physiological atrial heartbeat rates, the pacemaker functions in an AV synchronous pacing mode. For pathological atrial rates, atrial heartbeats occur too frequently for safe AV synchronous pacing so the heart is paced in the forced synchrony mode. In the forced synchrony mode, the pacemaker, upon sensing a natural atrial heartbeat, waits a predetermined atrial protection interval, paces the atria with an atrial stimulation pulse, waits a physiologically appropriate AV delay interval, and then delivers a ventricular pacing pulse at a time which maintains a stable ventricular rate.

Claims

1. A dual-chamber pacemaker comprising:

means for sensing an atrial heartbeat (A-sense);

means for sensing a ventricular heartbeat (V-sense);

means for generating an atrial pacing pulse (A-pace);

means for generating a ventricular pacing pulse (V-pace);

timer means for timing

(i) a ventricular event to ventricular event interval (VV), such VV interval beginning with either a V-sense or a V-pace,

(ii) an atrial event to V-pace interval (AV delay), such AV delay interval beginning with either an A-sense or an A-pace,

(iii) an atrial protection interval (API),

(iv) a post ventricular atrial refractory period (PVARP), and

(v) an Alert interval (Alert); and

controller means for providing a normal loop timing sequence of AV delay, PVARP, API, and Alert, with minimum time values for AV delay and API, and a maximum time value for AV delay;

said controller means operating such that if an A-sense occurs during said API or PVARP and the remaining time in the VV interval is longer than said maximum AV delay, then an API is timed, at the end thereof an Apace is generated, and thereafter an appropriate AV delay is timed so as to stabilize the VV interval.

2. A dual-chamber pacemaker according to claim 1 wherein said controller means operates such that if the remaining time in the VV interval is shorter than the sum of the minimum API and the minimum AV delay, then a minimum API is timed, at the end thereof an A-pace is generated, and thereafter a minimum AV delay is timed.

3. A dual-chamber pacemaker according to claim 1 further including means for determining a desired AV delay (current AV delay), and wherein said controller means operates such that if the remaining time in the VV interval is longer than the sum of the current AV delay and said minimum API, then an API equal to the remaining time in the VV interval minus the current AV delay is timed, at the end thereof an A-pace is generated, and thereafter an AV delay equal to the current AV delay is timed.

4. A dual-chamber pacemaker according to claim 1 further including means for determining a desired AV delay (current AV delay), and wherein said controller means operates such that if the remaining time in the VV interval is shorter than the sum of the minimum API and the current AV delay but longer than the sum of the minimum API and the minimum AV delay, then a minimum API is timed, at the end thereof an A-pace is generated, and thereafter an AV delay equal to the remaining time in the VV interval minus the minimum API is timed.

5. A dual-chamber pacemaker according to claim 1 wherein said controller means operates such that if the time remaining in the VV interval is less than the minimum AV delay and AV synchrony is preferred over VV stability, then an AV delay equal to the minimum AV delay is timed to complete the VV interval.

6. A dual-chamber pacemaker according to claim 1 wherein said controller means operates such that if the remaining time in the VV intervals is less than the minimum AV delay and VV stability is preferred over AV synchrony, then the time remaining in the VV interval is timed to complete the VV interval.

7. A dual-chamber pacemaker according to claims 1, 2, 3, 4, 5 or 6 wherein said controller means determines whether the current mode of operation is AV synchronous, non-AV synchronous, or in transition between one of said modes to the other, and in each normal loop timing sequence said VV interval is set to a value dependent on the current mode.

8. A dual-chamber pacemaker according to claim 7 further including means for determining the average atrial rate and means for determining a minimum VV interval, and wherein said controller means operates such that (i) if the current mode is in transition from AV synchronous to non-AV synchronous, then the VV interval is set in accordance with the average atrial rate during the last synchronous mode, (ii) if the current mode is AV synchronous, then the VV interval is set in accordance with the average atrial rate, (iii) if the current mode is in transition from non-AV synchronous to AV synchronous, then the VV interval is gradually decreased over a number of cycles to correspond with the average atrial rate, and (iv) if the current mode is non-AV synchronous, then the VV interval is gradually increased over a number of cycles to correspond with the maximum VV interval.

9. A dual-chamber pacemaker according to claim 7 further including rate responsive sensor means and wherein said controller means sets said VV interval as a function of the operation of said rate responsive sensor means.

10. A dual-chamber pacemaker comprising:

means for sensing an atrial heartbeat (A-sense);

means for sensing a ventricular heartbeat (V-sense);

means for generating an atrial pacing pulse (A-pace);

means for generating a ventricular pacing pulse (V-pace);

timer means for timing

(i) an atrial event to V-pace interval (AV delay), such AV delay interval bet;

inning with either an A-sense or an A-pace,

(ii) an atrial protection interval (API),

(iii) a post ventricular atrial refractory period (PVARP), and

(iv) an Alert interval (Alert); and

controller means for providing a normal loop timing sequence of AV delay, PVARP, API, and Alert;

said controller means operating such that if an A-sense occurs during said API and the remaining time in the loop timing sequence is sufficient, then an API is timed, at the end thereof an A-pace is generated, and thereafter an AV delay is timed.

11. A dual-chamber pacemaker according to claim 10 wherein said controller means operates such that if said remaining time is relatively short, then a minimum API is timed, at the end thereof an A-pace is generated, and thereafter a minimum AV delay is timed.

12. A dual-chamber pacemaker according to claim 11 further including means for determining a desired AV delay (current AV delay), and wherein said controller means operates such that if said remaining time is relatively long, then an API equal to said remaining time minus the current AV delay is timed, at the end thereof an A-pace is generated, and thereafter an AV delay equal to the current AV delay is timed.

13. A dual-chamber pacemaker according to claim 12 wherein said controller means operates such that if said remaining time is in an intermediate range, then a minimum API is timed, at the end thereof an A-pace is generated, and thereafter an AV delay equal to said remaining time in the VV interval minus the minimum API is timed.

14. A dual-chamber pacemaker according to claim 13 wherein said controller means operates such that if said remaining time is very short and AV synchrony is preferred over VV stability, then an AV delay equal to the minimum AV delay is timed to complete the loop timing sequence.

15. A dual-chamber pacemaker according to claim 13 wherein said controller means operates such that if said remaining time is very short and VV stability is preferred over AV synchrony, then .,.;

aid remaining time is timed to complete the loop timing sequence.

16. A dual-chamber pacemaker according to claim 10 wherein said controller means operates such that if said remaining time is very short and AV synchrony is preferred over VV stability, then an AV delay equal to the minimum AV delay is timed to complete the loop timing sequence.

17. A dual-chamber pacemaker according to claim 16 wherein said controller means operates such that if said remaining time is very short and VV stability is preferred over AV synchrony, then said remaining time is timed to complete the loop timing sequence.

18. A dual-chamber pacemaker according to claims 10, 11, 12, 13, 14, 15, 16 or 17 wherein said controller means determines whether the current mode of operation is AV synchronous, non-AV synchronous, or in transition between one of said modes to the other, and in each normal loop timing sequence the loop time is set to a value dependent on the current mode.

19. A dual-chamber pacemaker according to claim 18 further including means for determining the average atrial rate and means for determining a minimum loop time, and wherein said controller means operates such that (i) if the current mode is in transition from AV synchronous to non-AV synchronous, then the loop time is set in accordance with the average atrial rate during the last synchronous mode, (ii) if the current mode is AV synchronous, then the loop time is set in accordance with the average atrial rate, (iii) if the current mode is in transition from non-AV synchronous to AV synchronous, then the loop time is gradually decreased over a number of cycles to correspond with the average atrial rate, and (iv) if the current mode is non-AV synchronous, then the loop time is gradually increased over a number of cycles to correspond with the maximum loop time.

20. A dual-chamber pacemaker according to claim 18 further including rate responsive sensor means and wherein said controller means sets said loop time as a function of the operation of said rate responsive sensor means when the current mode is non-AV synchronous.

21. A method of operating a dual-chamber pacemaker comprising the steps of:

sensing an atrial heartbeat (A-sense);

sensing a ventricular heartbeat (V-sense);

generating an atrial pacing pulse (A-pace);

generating a ventricular pacing pulse (V-pace);

timing

(i) a ventricular event to ventricular event interval (VV), such VV interval beginning with either a V-sense or a V-pace,

(ii) an atrial event to V-pace interval (AV delay), such AV delay interval beginning with either an A-sense or an A-pace,

(iii) an atrial protection interval (API),

(iv) a post ventricular atrial refractory period (PVARP), and

(v) an Alert interval (Alert); and

providing a normal loop timing sequence of AV delay, PVARP, API, and Alert, with minimum time values for AV delay and API, and a maximum time value for AV delay;

wherein if an A-sense occurs prior to the Alert interval and the remaining time in the VV interval is longer than said maximum AV delay, then an API is timed, at the end thereof an A-pace is generated, and thereafter an AV delay is timed.

22. A method of operating a dual-chamber pacemaker according to claim 21 wherein if the remaining time in the VV interval is shorter than the sum of the minimum API and the minimum AV delay, then a minimum API is timed, at the end thereof an A-pace is generated, and thereafter a minimum AV delay is timed.

23. A method of operating a dual-chamber pacemaker according to claim 21 further including the step of determining a desired AV delay (current AV delay), and wherein if the remaining time in the VV interval is longer than the sum of the current AV delay and said minimum API, then an API equal to the remaining time in the VV interval minus the current AV delay is timed, at the end thereof an A-pace is generated, and thereafter an AV delay equal to the current AV delay is timed.

24. A method of operating a dual-chamber pacemaker according to claim 21 further including the step of determining a desired AV delay (current AV delay), and wherein if the remaining time in the VV interval is shorter than the sum of the minimum API and the current AV delay but longer than the sum of the minimum API and the minimum AV delay, then a minimum API is timed, at the end thereof an A-pace is generated, and thereafter an AV delay equal to the remaining time in the VV interval minus the minimum API is timed.

25. A method of operating a dual-chamber pacemaker according to claim 21 wherein if the time remaining in the VV interval is less than the minimum AV delay and AV synchrony is preferred over VV stability, then an AV delay equal to the minimum AV delay is timed to complete the VV interval.

26. A method of operating a dual-chamber pacemaker according to claim 21 wherein if the remaining time in the VV interval is less than the minimum AV delay and VV stability is preferred over AV synchrony, then the time remaining in the VV interval is timed to complete the VV interval.

27. A method of operating a dual.-chamber pacemaker according to claims 21, 22, 23, 24, 25 or 26 further including the step of determining whether the current mode of operation is AV synchronous, non-AV synchronous, or in transition between one of said modes to the other, and in each normal loop timing sequence said VV interval is set to a value dependent on the current mode.

28. A method of operating a dual.-chamber pacemaker according to claim 27 further including the step of determining the average atrial rate and a minimum VV interval, and wherein (i) if the current mode is in transition from AV synchronous to non-AV synchronous, then the VV interval is set in accordance with the average atrial rate during the last synchronous mode, (ii) if the current mode is AV synchronous, then the VV interval is set in accordance with the average atrial rate, (iii) if the current mode is in transition from non-AV synchronous to AV synchronous, then the VV interval is gradually decreased over a number of cycles to correspond with the average atrial rate, and (iv) if the current mode is non-AV synchronous, then the VV interval is gradually increased over a number of cycles to correspond with the maximum VV interval.

29. A method of operating a dual-chamber pacemaker according to claim 27 further including the step of setting said VV interval as a function of the rate response of the pacemaker when the current mode is non-AV synchronous.

30. A method of operating a dual-chamber pacemaker comprising the steps of:

sensing an atrial heartbeat (A-sense);

sensing a ventricular heartbeat (V-sense);

generating an atrial pacing pulse (A-pace);

generating a ventricular pacing pulse (V-pace);

timing

(i) an atrial event to V-pace interval (AV delay), such AV delay interval beginning with either an A-sense or an A-pace,

(ii) an atrial protection interval (API),

(iii) a post ventricular atrial refractory period (PVARP), and

(iv) an Alert interval (Alert); and

providing a normal loop timing sequence of AV delay, PVARP, API, and Alert;

wherein if an A-sense occurs prior to the Alert interval and the remaining time in the loop tinting sequence is sufficient, then an API is timed, at the end thereof an Apace is generated, and thereafter an AV delay is timed.

31. A method of operating a dual-chamber pacemaker according to claim 30 wherein if said remaining time is relatively short, then a minimum API is timed, at the end thereof an A-pace is generated, and thereafter a minimum AV delay is timed.

32. A method of operating a dual.-chamber pacemaker according to claim 31 further including the step of determining a desired AV delay (current AV delay), and wherein if said remaining time is relatively long, then an API equal to said remaining time minus the current AV delay is timed, at the end thereof an A-pace is generated, and thereafter an AV delay equal to the current AV delay is timed.

33. A method of operating a dual-chamber pacemaker according to claim 32 wherein if said remaining time is in an intermediate range, then a minimum API is timed, at the end thereof an A-pace is generated, and thereafter an AV delay equal to said remaining time minus the minimum API is timed.

34. A method of operating a dual-.chamber pacemaker according to claim 33 wherein if said remaining time is very short and AV synchrony is preferred over VV stability, then an AV delay equal to the minimum AV delay is timed to complete the loop timing sequence.

35. A method of operating a dual-chamber pacemaker according to claim 33 wherein if said remaining time is very short and VV stability is preferred over AV synchrony, then said remaining time is timed to complete the loop timing sequence.

36. A method of operating a dual-chamber pacemaker according to claim 30 wherein if said remaining time is very short and AV synchrony is preferred over VV stability, then an AV delay equal to the minimum AV delay is timed to complete the loop timing sequence.

37. A method of operating a dual-chamber pacemaker according to claim 36 wherein if said remaining time is very short and VV stability is preferred over AV synchrony, then said remaining time is timed to complete the loop timing sequence.

38. A method of operating a dual-chamber pacemaker according to claims 30, 31, 32, 33, 34, 35, 36 or 37 further including the step of determining whether the current mode of operation is AV synchronous, non-AV synchronous, or in transition between one of said modes to the other, and in each normal loop timing sequence the loop time is set to a value dependent on the current mode.

39. A method of operating a dual-chamber pacemaker according to claim 38 further including the step of determining the average atrial rate and a minimum loop time, and wherein (i) if the current mode is in transition from AV synchronous to non-AV synchronous, then the loop time is set in accordance with the average atrial rate during the last synchronous mode, (ii) if the current mode is AV synchronous, then the loop time is set in accordance with the average atrial rate, (iii) if the current mode is in transition from non-AV synchronous to AV synchronous, then the loop time is gradually decreased over a number of cycles to correspond with the average atrial rate, and (iv) if the current mode is non-AV synchronous, then the loop time is gradually increased over a number of cycles to correspond with the maximum loop time.

40. A method of operating a dual-chamber pacemaker according to claim 38 further including the step of setting said 10op time as a function of the rate response of the pacemaker when the current mode is non-AV synchronous.