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Stabilized solid pharmaceutical composition containing acid addition salts of a basic drug and an alkaline stabilizer

  • US 5,441,747 A
  • Filed: 02/09/1994
  • Issued: 08/15/1995
  • Est. Priority Date: 09/13/1990
  • Status: Expired due to Term
First Claim
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1. A dry pharmaceutical preparation consisting essentially of a water soluble acid addition salt of a poorly soluble basic drug selected from the group consisting of apomorphine, chlorpromazine, imipramine, promethazine, and mianserin;

  • and excipients selected from the group consisting of microcrystalline cellulose, lactose, and calcium hydrogen phosphate in an amount from about 30 to about 80 percent by weight of the dry pharmaceutical preparation; and

    a water soluble alkaline stabilizer in an amount from about 0.5 to about 10 percent by weight of the dry pharmaceutical preparation, wherein said stabilizer is selected from the group consisting of sodium bicarbonate, ammonium carbonate, sodium citrate, dibasic sodium phosphate, anhydrous dibasic sodium biphosphate, diammonium hydrogen phosphate, sodium pyrophosphate and mixtures thereof.

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