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Biological conjugates of fluorescent rhodol dyes

  • US 5,442,045 A
  • Filed: 03/08/1993
  • Issued: 08/15/1995
  • Est. Priority Date: 04/16/1990
  • Status: Expired due to Term
First Claim
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1. A compound comprising a fluorescent dye having the structure ##STR2## wherein R1 is H or CH3, and R2 is H, CF3 CO, CH3, or C2 H5 ;

  • or R1 in combination with R2 is (CH2)3 ;

    R3 is H, CH3, or C2 H5, and R4 is H;

    or R3 in combination with R4 is (CH2)3 ;

    R5 is H, CH2 NH2, CH2 NHCOCH2 Cl, CH2 NHCOCH2 I;

    CH2 NHCOCH═

    CH2, or CH2 NHCOC6 H4 N3 ;

    R6 is H, Cl, Br, CH3, or C2 H5, or (CH2)n CH3 where n is an integer from 0 to 15, or (CH2)n CO2 H, where n is an integer from 0 to 11;

    R7 is H, CO2 H, ##STR3## NH2, NCS, CH2 NHCOCH2 Cl, or CH2 NHCOCH2 I;

    such that R7 is not H if R5 is H;

    conjugated to a reactive site on a biomolecule via reaction of a chemically reactive functional group on the dye with a reactive site on the biomolecule.

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