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Osmotic device for delayed delivery of agent

  • US 5,443,459 A
  • Filed: 08/19/1993
  • Issued: 08/22/1995
  • Est. Priority Date: 01/30/1991
  • Status: Expired due to Term
First Claim
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1. A dispensing device for providing a pulsed delivery of at least one active agent formulation to a fluid-containing environment of use, which device comprises a plurality of nested capsules, each succeeding capsule being nested within the preceding capsule, each capsule comprising a housing having a first wall section and a second wall section in reversibly sliding telescopic arrangement, which wall sections are assembled together to define an internal compartment which contains an active agent formulation and expansion means and the next succeeding capsule, if any, wherein at least one of said wall sections of each capsule is, at least in part, permeable to fluid in the environment of use, the arrangement being such that in said environment of use fluid enters into the internal compartment of the first outer capsule and interacts with said expansion means, thereby causing the expansion means to expand and to exert a separating force on the wall sections of said first capsule, whereby, after a period of time, said wall sections of said first capsule are disassembled from each other thereby exposing the contents of the said internal compartment to the said environment of use and allowing delivery of said active agent formulation therein and the ingress of fluid into the next succeeding capsule, thereby to provide the said pulsed delivery of active agent.

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